4XJE

CRYSTAL STRUCTURE OF ANT(2") IN COMPLEX WITH AMP AND TOBRAMYCIN

Summary for 4XJE

Entry DOI	10.2210/pdb4xje/pdb
Related	1KNY 3ISD 5CFS 5CFT 5CFU
Descriptor	AadB, ADENOSINE MONOPHOSPHATE, TOBRAMYCIN, ... (5 entities in total)
Functional Keywords	antibiotic resistance, nucleotidyltransferase, tobramycin, rossmann fold, transferase-antibiotic complex, transferase/antibiotic
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	1
Total formula weight	21871.35
Authors	Rodionov, D.,Bassenden, A.V.,Berghuis, A.M. (deposition date: 2015-01-08, release date: 2016-01-20, Last modification date: 2024-02-28)
Primary citation	Bassenden, A.V.,Park, J.,Rodionov, D.,Berghuis, A.M. Revisiting the Catalytic Cycle and Kinetic Mechanism of AminoglycosideO-Nucleotidyltransferase(2′′): A Structural and Kinetic Study. Acs Chem.Biol., 2020 Cited by PubMed: 32100995 DOI: 10.1021/acschembio.9b00904 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation