6W20
 
 | | ClpAP Disengaged State bound to RepA-GFP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ... | | Authors: | Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R. | | Deposit date: | 2020-03-04 | | Release date: | 2020-05-06 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
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6W24
 | | ClpA Engaged2 State bound to RepA-GFP (Focused Classification) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ... | | Authors: | Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R. | | Deposit date: | 2020-03-04 | | Release date: | 2020-05-06 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
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7BYN
 | | Cryo-EM structure of human KCNQ4 with linopirdine | | Descriptor: | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one, Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, ... | | Authors: | Shen, H, Li, T, Yue, Z. | | Deposit date: | 2020-04-23 | | Release date: | 2020-12-02 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
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7BYL
 | | Cryo-EM structure of human KCNQ4 | | Descriptor: | Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ... | | Authors: | Shen, H, Li, T, Yue, Z. | | Deposit date: | 2020-04-23 | | Release date: | 2020-12-02 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
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8K4S
 | | CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P | | Descriptor: | (4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Yang, J, Fan, J.P, Lei, X.G. | | Deposit date: | 2023-07-20 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.
Cell, 187, 2024
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5WUA
 | | Structure of a Pancreatic ATP-sensitive Potassium Channel | | Descriptor: | ATP-sensitive inward rectifier potassium channel 11,superfolder GFP, SUR1 | | Authors: | Li, N, Wu, J.-X, Chen, L, Gao, N. | | Deposit date: | 2016-12-16 | | Release date: | 2017-01-25 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (5.6 Å) | | Cite: | Structure of a Pancreatic ATP-Sensitive Potassium Channel
Cell, 168, 2017
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3RAA
 | | Structural studies of AAV8 capsid transitions associated with endosomal trafficking | | Descriptor: | ADENOSINE MONOPHOSPHATE, Capsid protein | | Authors: | Nam, H.-J, Gurda, B, McKenna, R, Porter, M, Byrne, B, Salganik, M, Muzyczka, N, Agbandje-McKenna, M. | | Deposit date: | 2011-03-27 | | Release date: | 2011-09-21 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.
J.Virol., 85, 2011
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3RA4
 | | Structural studies of AAV8 capsid transitions associated with endosomal trafficking | | Descriptor: | Capsid protein, DNA (5'-D(*CP*A)-3') | | Authors: | Nam, H.-J, Gurda, B, McKenna, R, Porter, M, Byrne, B, Salganik, M, Muzyczka, N, Agbandje-McKenna, M. | | Deposit date: | 2011-03-27 | | Release date: | 2011-09-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.
J.Virol., 85, 2011
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3RA2
 | | Structural studies of AAV8 capsid transitions associated with endosomal trafficking | | Descriptor: | Capsid protein | | Authors: | Nam, H.-J, Gurda, B, McKenna, R, Porter, M, Byrne, B, Salganik, M, Muzyczka, N, Agbandje-McKenna, M. | | Deposit date: | 2011-03-26 | | Release date: | 2011-09-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.
J.Virol., 85, 2011
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3RA9
 | | Structural studies of AAV8 capsid transitions associated with endosomal trafficking | | Descriptor: | Capsid protein, DNA (5'-D(P*CP*A)-3') | | Authors: | Nam, H.-J, Gurda, B, McKenna, R, Porter, M, Byrne, B, Salganik, M, Muzyczka, N, Agbandje-McKenna, M. | | Deposit date: | 2011-03-27 | | Release date: | 2011-09-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.
J.Virol., 85, 2011
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3RA8
 | | Structural studies of AAV8 capsid transitions associated with endosomal trafficking | | Descriptor: | ADENOSINE MONOPHOSPHATE, Capsid protein | | Authors: | Nam, H.-J, Gurda, B, McKenna, R, Porter, M, Byrne, B, Salganik, M, Muzyczka, N, Agbandje-McKenna, M. | | Deposit date: | 2011-03-27 | | Release date: | 2011-09-21 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.
J.Virol., 85, 2011
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6ITC
 | | Structure of a substrate engaged SecA-SecY protein translocation machine | | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Ma, C.Y, Wu, X.F, Sun, D.J, Park, E.Y, Rapoport, T.A, Gao, N, Long, L. | | Deposit date: | 2018-11-21 | | Release date: | 2019-06-12 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structure of the substrate-engaged SecA-SecY protein translocation machine.
Nat Commun, 10, 2019
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6HR1
 | | Crystal structure of the YFPnano fusion protein | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | | Authors: | Benoit, R.M. | | Deposit date: | 2018-09-26 | | Release date: | 2020-04-08 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Chimeric single alpha-helical domains as rigid fusion protein connections for protein nanotechnology and structural biology.
Structure, 2021
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8OVN
 | | X-ray structure of the SF-iGluSnFR-S72A | | Descriptor: | CITRIC ACID, Putative periplasmic binding transport protein,Green fluorescent protein | | Authors: | Tarnawski, M, Hellweg, L, Bergner, A, Hiblot, J, Leippe, P, Johnsson, K. | | Deposit date: | 2023-04-26 | | Release date: | 2023-05-17 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | X-ray structure of the SF-iGluSnFR-S72A
To Be Published
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8OVO
 | | X-ray structure of the SF-iGluSnFR-S72A in complex with L-aspartate | | Descriptor: | ASPARTIC ACID, Putative periplasmic binding transport protein,Green fluorescent protein | | Authors: | Tarnawski, M, Hellweg, L, Bergner, A, Hiblot, J, Leippe, P, Johnsson, K. | | Deposit date: | 2023-04-26 | | Release date: | 2023-05-17 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | X-ray structure of the SF-iGluSnFR-S72A in complex with L-aspartate
To Be Published
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8OVP
 | | X-ray structure of the iAspSnFR in complex with L-aspartate | | Descriptor: | ACETATE ION, ASPARTIC ACID, MAGNESIUM ION, ... | | Authors: | Tarnawski, M, Hellweg, L, Bergner, A, Hiblot, J, Leippe, P, Johnsson, K. | | Deposit date: | 2023-04-26 | | Release date: | 2023-05-17 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | X-ray structure of the SF-iAspSnFR in complex with L-aspartate
To Be Published
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6WVG
 | | human CD53 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Green fluorescent protein, ... | | Authors: | Yang, Y, Liu, S, Li, W. | | Deposit date: | 2020-05-06 | | Release date: | 2020-09-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Open conformation of tetraspanins shapes interaction partner networks on cell membranes.
Embo J., 39, 2020
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3EK7
 | | Calcium-saturated GCaMP2 dimer | | Descriptor: | CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... | | Authors: | Akerboom, J, Velez Rivera, J.D, Looger, L.L, Schreiter, E.R. | | Deposit date: | 2008-09-18 | | Release date: | 2008-12-16 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
J.Biol.Chem., 284, 2009
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9GU3
 | | Human adult muscle nAChR in desensitised state in nanodisc with 1 mM acetylcholine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Li, A, Pike, A.C.W, Chi, G, Webster, R, Maxwell, S, Liu, W, Beeson, D, Sauer, D.B, Dong, Y.Y. | | Deposit date: | 2024-09-18 | | Release date: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | Structures of the human adult muscle-type nicotinic receptor in resting and desensitized states.
Cell Rep, 44, 2025
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3EKH
 | | Calcium-saturated GCaMP2 T116V/K378W mutant monomer | | Descriptor: | CALCIUM ION, GLYCEROL, Myosin light chain kinase, ... | | Authors: | Akerboom, J, Velez Rivera, J.D, Looger, L.L, Schreiter, E.R. | | Deposit date: | 2008-09-19 | | Release date: | 2008-12-16 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
J.Biol.Chem., 284, 2009
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3EK8
 | | Calcium-saturated GCaMP2 T116V/G87R mutant monomer | | Descriptor: | CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... | | Authors: | Akerboom, J, Velez Rivera, J.D, Looger, L.L, Schreiter, E.R. | | Deposit date: | 2008-09-19 | | Release date: | 2008-12-16 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
J.Biol.Chem., 284, 2009
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8DN2
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8DN5
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8DN4
 | | Cryo-EM structure of human Glycine Receptor alpha-1 beta heteromer, glycine-bound state3(desensitized state) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alpha-1, Glycine receptor subunit beta,Green fluorescent protein,Glycine receptor beta, ... | | Authors: | Liu, X, Wang, W. | | Deposit date: | 2022-07-10 | | Release date: | 2023-10-11 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Asymmetric gating of a human hetero-pentameric glycine receptor.
Nat Commun, 14, 2023
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8DN3
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