2BQW
| CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 45 | Descriptor: | 1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE, CALCIUM ION, COAGULATION FACTOR X, ... | Authors: | Nazare, M, Will, D.W, Matter, H, Schreuder, H, Ritter, K, Urmann, M, Essrich, M, Bauer, A, Wagner, M, Czech, J, Laux, V, Wehner, V. | Deposit date: | 2005-04-28 | Release date: | 2006-04-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-Ray Crystallography. J.Med.Chem., 48, 2005
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1NX6
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1NNO
| CONFORMATIONAL CHANGES OCCURRING UPON NO BINDING IN NITRITE REDUCTASE FROM PSEUDOMONAS AERUGINOSA | Descriptor: | HEME C, HEME D, NITRIC OXIDE, ... | Authors: | Nurizzo, D, Tegoni, M, Cambillau, C. | Deposit date: | 1998-07-20 | Release date: | 1999-04-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Conformational changes occurring upon reduction and NO binding in nitrite reductase from Pseudomonas aeruginosa. Biochemistry, 37, 1998
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3LGT
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3LH3
| DFP modified DegS delta PDZ | Descriptor: | Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3LVM
| Crystal Structure of E.coli IscS | Descriptor: | Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Shi, R, Proteau, A, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2010-02-22 | Release date: | 2010-04-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. Plos Biol., 8, 2010
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5WRK
| Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y608 peptide | Descriptor: | AP-2 complex subunit mu, Insulin receptor substrate 1, NICKEL (II) ION | Authors: | Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S. | Deposit date: | 2016-12-02 | Release date: | 2017-12-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling Elife, 7, 2018
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1NPV
| Crystal structure of HIV-1 protease complexed with LDC271 | Descriptor: | POL polyprotein, {1-BENZYL-3-[2-BENZYL-3-OXO-4-(1-OXO-1,2,3,4-TETRAHYDRO- ISOQUINOLIN-4-YL)-2,3-DIHYDRO-1H-PYRROL-2-YL]-2- HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | Authors: | Smith, A.B. | Deposit date: | 2003-01-20 | Release date: | 2003-02-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors. J.Med.Chem., 46, 2003
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4POR
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1NWC
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2BIY
| Structure of PDK1-S241A mutant kinase domain | Descriptor: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | Authors: | Komander, D, Kular, G.S, Deak, M, Alessi, D.R, van Aalten, D.M.F. | Deposit date: | 2005-01-26 | Release date: | 2005-02-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding. J. Biol. Chem., 280, 2005
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1O0R
| Crystal structure of the catalytic domain of bovine beta1,4-galactosyltransferase complex with UDP-galactose | Descriptor: | 1,4-DIETHYLENE DIOXIDE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GALACTOSE-URIDINE-5'-DIPHOSPHATE, ... | Authors: | Ramakrishnan, B, Balaji, P.V, Qasba, P.K. | Deposit date: | 2003-02-24 | Release date: | 2003-03-04 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | CRYSTAL STRUCTURE OF BETA 1,4-GALACTOSYLTRANSFERASE COMPLEX WITH UDP-GAL
REVEALS AN OLIGOSACCHARIDE ACCEPTOR BINDING SITE J.Mol.Biol., 318, 2002
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2BQ7
| Crystal structure of factor Xa in complex with 43 | Descriptor: | CALCIUM ION, COAGULATION FACTOR X, FACTOR XA, ... | Authors: | Nazare, M, Will, D.W, Matter, H, Schreuder, H, Ritter, K, Urmann, M, Essrich, M, Bauer, A, Wagner, M, Czech, J, Laux, V, Wehner, V. | Deposit date: | 2005-04-27 | Release date: | 2006-04-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-Ray Crystallography. J.Med.Chem., 48, 2005
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2BWU
| Asp271Ala Escherichia coli Aminopeptidase P | Descriptor: | AMINOPEPTIDASE P, CITRATE ANION, MAGNESIUM ION, ... | Authors: | Graham, S.C, Guss, J.M. | Deposit date: | 2005-07-19 | Release date: | 2006-01-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Kinetic and Crystallographic Analysis of Mutant Escherichia Coli Aminopeptidase P: Insights Into Substrate Recognition and the Mechanism of Catalysis. Biochemistry, 45, 2006
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4Q1L
| Crystal structure of Leucurolysin-a complexed with an endogenous tripeptide (QSW). | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Ferreira, R.N, Sanchez, E.O.F, Pimenta, A.M.C, Nagem, R.A.P. | Deposit date: | 2014-04-03 | Release date: | 2015-04-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of Leucurolysin-a complexed with an endogenous tripeptide (QSW). To be Published
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2BK5
| Human Monoamine Oxidase B: I199F mutant in complex with isatin | Descriptor: | AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, ISATIN | Authors: | Binda, C, Edmondson, D.E, Mattevi, A, Hubalek, F, Khalil, A, Li, M, Castagnoli, N. | Deposit date: | 2005-02-10 | Release date: | 2005-02-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors. J.Biol.Chem., 280, 2005
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2C3I
| CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I | Descriptor: | 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, PIMTIDE, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1 | Authors: | Philippakopoulos, P, Knapp, S, Debreczeni, J, Bullock, A, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Guo, K, Weigelt, J. | Deposit date: | 2005-10-07 | Release date: | 2005-11-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Analysis Identifies Imidazo[1,2- B]Pyridazines as Pim Kinase Inhibitors with in Vitro Antileukemic Activity. Cancer Res., 67, 2007
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1O7J
| Atomic resolution structure of Erwinia chrysanthemi L-asparaginase | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, L-ASPARAGINASE, ... | Authors: | Lubkowski, J, Dauter, M, Aghaiypour, K, Wlodawer, A, Dauter, Z. | Deposit date: | 2002-11-07 | Release date: | 2002-12-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Atomic Resolution Structure of Erwinia Chrysanthemi L-Asparaginase Acta Crystallogr.,Sect.D, 59, 2003
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3MC0
| Crystal Structure of Staphylococcal Enterotoxin G (SEG) in Complex with a Mouse T-cell Receptor beta Chain | Descriptor: | ACETATE ION, Enterotoxin SEG, variable beta 8.2 mouse T cell receptor | Authors: | Fernandez, M.M, Cho, S, Robinson, H, Mariuzza, R.A, Malchiodi, E.L. | Deposit date: | 2010-03-26 | Release date: | 2010-10-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of staphylococcal enterotoxin G (SEG) in complex with a mouse T-cell receptor {beta} chain. J.Biol.Chem., 286, 2011
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3IDY
| Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C2221 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab b13 heavy chain, Fab b13 light chain, ... | Authors: | Chen, L, Kwon, Y.D, Zhou, T, Wu, X, O'Dell, S, Cavacini, L, Hessell, A.J, Pancera, M, Tang, M, Xu, L, Yang, Z.Y, Zhang, M.Y, Arthos, J, Burton, D.R, Dimitrov, D.S, Nabel, G.J, Posner, M, Sodroski, J, Wyatt, R, Mascola, J.R, Kwong, P.D. | Deposit date: | 2009-07-22 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120. Science, 326, 2009
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1NWH
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2VC4
| Ricin A-Chain (Recombinant) E177D Mutant | Descriptor: | GLYCEROL, RICIN A CHAIN, SULFATE ION | Authors: | Marsden, C.J, Fulop, V. | Deposit date: | 2007-09-18 | Release date: | 2007-10-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | The Isolation and Characterisation of Temperature-Dependent Ricin a Chain Molecules in Saccharomyces Cerevisiae FEBS J., 274, 2007
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2VC3
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8DPN
| CryoEM structure of Azotobacter vinelandii nitrogenase MoFeP during catalytic N2 reduction | Descriptor: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, FE (III) ION, FE(8)-S(7) CLUSTER, ... | Authors: | Rutledge, H.L, Cook, B, Tezcan, F.A, Herzik, M.A. | Deposit date: | 2022-07-15 | Release date: | 2022-08-17 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | Structures of the nitrogenase complex prepared under catalytic turnover conditions. Science, 377, 2022
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8UH6
| Degrader-induced complex between PTPN2 and CRBN-DDB1 | Descriptor: | (5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[(4-{1-[(3R)-2,6-dioxopiperidin-3-yl]-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}piperidine-1-carbonyl)amino]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid, DNA damage-binding protein 1, Protein cereblon, ... | Authors: | Catalano, C, Bratkowski, M, Scapin, G, Hao, Q. | Deposit date: | 2023-10-06 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex. Commun Chem, 7, 2024
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