8B22
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8B23
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8B21
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![BU of 8b21 by Molmil](/molmil-images/mine/8b21) | Time-resolved structure of K+-dependent Na+-PPase from Thermotoga maritima 0-60-seconds post reaction initiation with Na+ | Descriptor: | DI(HYDROXYETHYL)ETHER, DODECYL-BETA-D-MALTOSIDE, K(+)-stimulated pyrophosphate-energized sodium pump, ... | Authors: | Strauss, J, Vidilaseris, K, Goldman, A. | Deposit date: | 2022-09-12 | Release date: | 2024-01-17 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Functional and structural asymmetry suggest a unifying principle for catalysis in membrane-bound pyrophosphatases. Embo Rep., 25, 2024
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6C1K
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![BU of 6c1k by Molmil](/molmil-images/mine/6c1k) | HypoPP mutant with ligand1 | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GUANIDINE, Ion transport protein, ... | Authors: | Catterall, W.A, Zheng, N, Jiang, D, Gamal El-Din, T.M. | Deposit date: | 2018-01-04 | Release date: | 2018-05-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for gating pore current in periodic paralysis. Nature, 557, 2018
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3E83
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![BU of 3e83 by Molmil](/molmil-images/mine/3e83) | Crystal Structure of the the open NaK channel pore | Descriptor: | CESIUM ION, Potassium channel protein, SODIUM ION | Authors: | Jiang, Y, Alam, A. | Deposit date: | 2008-08-19 | Release date: | 2008-12-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural analysis of ion selectivity in the NaK channel Nat.Struct.Mol.Biol., 16, 2009
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4UZU
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![BU of 4uzu by Molmil](/molmil-images/mine/4uzu) | Three-dimensional structure of a variant `Termamyl-like' Geobacillus stearothermophilus alpha-amylase at 1.9 A resolution | Descriptor: | ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION, ... | Authors: | Offen, W.A, Anderson, C, Borchert, T.V, Wilson, K.S, Davies, G.J. | Deposit date: | 2014-09-09 | Release date: | 2015-01-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Three-Dimensional Structure of a Variant `Termamyl-Like' Geobacillus Stearothermophilus Alpha-Amylase at 1.9 A Resolution Acta Crystallogr.,Sect.F, 71, 2015
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6RF0
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![BU of 6rf0 by Molmil](/molmil-images/mine/6rf0) | Crystal structure of the light-driven sodium pump KR2 in the pentameric "dry" form | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, EICOSANE, RETINAL, ... | Authors: | Kovalev, K, Polovinkin, V, Gushchin, I, Borshchevskiy, V, Gordeliy, V. | Deposit date: | 2019-04-12 | Release date: | 2019-04-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure and mechanisms of sodium-pumping KR2 rhodopsin. Sci Adv, 5, 2019
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6A95
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![BU of 6a95 by Molmil](/molmil-images/mine/6a95) | Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with tetrodotoxin and Dc1a | Descriptor: | (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Shen, H.Z, li, Z.Q, Jiang, Y, Pan, X.J, Wu, J.P, Cristofori-Armstrong, B, Smith, J.J, Chin, Y.K.Y, Lei, J.L, Zhou, Q, King, G.F, Yan, N. | Deposit date: | 2018-07-11 | Release date: | 2018-08-08 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science, 362, 2018
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5U16
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![BU of 5u16 by Molmil](/molmil-images/mine/5u16) | Structure of human MR1-2-OH-1-NA in complex with human MAIT A-F7 TCR | Descriptor: | 2-hydroxynaphthalene-1-carbaldehyde, Beta-2-microglobulin, CHLORIDE ION, ... | Authors: | Keller, A.N, Birkinshaw, R.W, Rossjohn, J. | Deposit date: | 2016-11-27 | Release date: | 2017-02-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Nat. Immunol., 18, 2017
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4XNU
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![BU of 4xnu by Molmil](/molmil-images/mine/4xnu) | X-ray structure of Drosophila dopamine transporter in complex with nisoxetine | Descriptor: | CHLORIDE ION, CHOLESTEROL, Integral membrane protein-dopamine transporter, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat.Struct.Mol.Biol., 22, 2015
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3KDP
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![BU of 3kdp by Molmil](/molmil-images/mine/3kdp) | Crystal structure of the sodium-potassium pump | Descriptor: | CHOLESTEROL, MAGNESIUM ION, Na+/K+ ATPase gamma subunit transcript variant a, ... | Authors: | Morth, J.P, Pedersen, B.P, Nissen, P. | Deposit date: | 2009-10-23 | Release date: | 2010-02-16 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structure of the sodium-potassium pump. Nature, 450, 2007
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5NKQ
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![BU of 5nkq by Molmil](/molmil-images/mine/5nkq) | Crystal structure of a dual topology fluoride ion channel. | Descriptor: | FLUORIDE ION, Monobody, Putative fluoride ion transporter CrcB, ... | Authors: | Stockbridge, R, Miller, C, Newstead, S. | Deposit date: | 2017-03-31 | Release date: | 2017-04-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Crystal structures of a double-barrelled fluoride ion channel. Nature, 525, 2015
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8RUK
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![BU of 8ruk by Molmil](/molmil-images/mine/8ruk) | Structure of Oceanobacillus iheyensis group II intron in the presence of Na+, Mg2+, and ARN25850 | Descriptor: | 2-[2,6-bis(bromanyl)-3,4,5-tris(oxidanyl)phenyl]carbonyl-~{N}-(2-pyrrolidin-1-ylethyl)-1-benzofuran-5-carboxamide, Domains 1-5, MAGNESIUM ION, ... | Authors: | Silvestri, I, Marcia, M. | Deposit date: | 2024-01-31 | Release date: | 2024-06-19 | Last modified: | 2024-07-03 | Method: | X-RAY DIFFRACTION (4.81 Å) | Cite: | Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. Nat Commun, 15, 2024
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2PFQ
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![BU of 2pfq by Molmil](/molmil-images/mine/2pfq) | Manganese promotes catalysis in a DNA polymerase lambda-DNA crystal | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA polymerase lambda, Downstream Primer, ... | Authors: | Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Pedersen, L.C, Kunkel, T.A. | Deposit date: | 2007-04-05 | Release date: | 2007-05-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Role of the catalytic metal during polymerization by DNA polymerase lambda. DNA Repair, 6, 2007
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7LW1
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![BU of 7lw1 by Molmil](/molmil-images/mine/7lw1) | Human phosphofructokinase-1 liver type bound to activator NA-11 | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 6-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Lynch, E.M, Kollman, J.M, Webb, B. | Deposit date: | 2021-02-27 | Release date: | 2022-01-26 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Selective activation of PFKL suppresses the phagocytic oxidative burst. Cell, 184, 2021
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7OOR
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![BU of 7oor by Molmil](/molmil-images/mine/7oor) | NaK C-DI mutant with Na+ and K+ | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... | Authors: | Minniberger, S, Plested, A.J.R. | Deposit date: | 2021-05-28 | Release date: | 2022-06-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
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7OQ1
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![BU of 7oq1 by Molmil](/molmil-images/mine/7oq1) | NaK S-ELM mutant with Na+ and K+ | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | Authors: | Minniberger, S, Plested, A.J.R. | Deposit date: | 2021-06-02 | Release date: | 2022-06-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
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7OQ2
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![BU of 7oq2 by Molmil](/molmil-images/mine/7oq2) | NaK S-DI mutant soaked in Na+ | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, POTASSIUM ION, ... | Authors: | Minniberger, S, Plested, A.J.R. | Deposit date: | 2021-06-02 | Release date: | 2022-06-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
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8GNK
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![BU of 8gnk by Molmil](/molmil-images/mine/8gnk) | CryoEM structure of cytosol-facing, substrate-bound ratGAT1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CHOLESTEROL, ... | Authors: | Nayak, S.R, Joseph, D, Penmatsa, A. | Deposit date: | 2022-08-24 | Release date: | 2023-05-31 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism. Nat.Struct.Mol.Biol., 30, 2023
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3DYO
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![BU of 3dyo by Molmil](/molmil-images/mine/3dyo) | E. coli (lacZ) beta-galactosidase (H418N) in complex with IPTG | Descriptor: | 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... | Authors: | Juers, D.H, Huber, R.E, Matthews, B.W. | Deposit date: | 2008-07-28 | Release date: | 2008-10-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Direct and indirect roles of His-418 in metal binding and in the activity of beta-galactosidase (E. coli). Protein Sci., 18, 2009
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3E1F
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8W9T
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7W9P
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![BU of 7w9p by Molmil](/molmil-images/mine/7w9p) | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV pi helix conformer) | Descriptor: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | Deposit date: | 2021-12-10 | Release date: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
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7W9L
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![BU of 7w9l by Molmil](/molmil-images/mine/7w9l) | Cryo-EM structure of human Nav1.7(E406K)-beta1-beta2 complex | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | Deposit date: | 2021-12-10 | Release date: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
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3L8L
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![BU of 3l8l by Molmil](/molmil-images/mine/3l8l) | Gramicidin D complex with sodium iodide | Descriptor: | GRAMICIDIN D, IODIDE ION, METHANOL, ... | Authors: | Olczak, A, Glowka, M.L, Szczesio, M, Bojarska, J, Wawrzak, Z, Duax, W.L. | Deposit date: | 2009-12-31 | Release date: | 2010-07-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | The first crystal structure of a gramicidin complex with sodium: high-resolution study of a nonstoichiometric gramicidin D-NaI complex. Acta Crystallogr.,Sect.D, 66, 2010
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