8QR5
 
 | | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand | | Descriptor: | (5~{S},6~{S})-5,6,15,17-tetrakis(oxidanyl)-2,12-dioxabicyclo[12.4.0]octadeca-1(14),15,17-triene-7,13-dione, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | | Authors: | Gelin, M, Labesse, G. | | Deposit date: | 2023-10-06 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand
To Be Published
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8QR7
 | | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand | | Descriptor: | (4~{S},9~{S},10~{S})-4-methyl-9,10,16,18-tetrakis(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dione, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | | Authors: | Gelin, M, Labesse, G. | | Deposit date: | 2023-10-06 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand
To Be Published
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8QRB
 | | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand | | Descriptor: | (4~{S},7~{R},9~{S},10~{S},12~{E})-7-fluoranyl-4-methyl-9,10,16,18-tetrakis(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | | Authors: | Gelin, M, Labesse, G. | | Deposit date: | 2023-10-06 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand
To Be Published
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8QR9
 | | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand | | Descriptor: | (4~{S},9~{S},10~{S})-17-(ethoxymethoxy)-4-methyl-9,10,19-tris(oxidanyl)-3-oxabicyclo[13.4.0]nonadeca-1(19),15,17-triene-2,8-dione, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | | Authors: | Gelin, M, Labesse, G. | | Deposit date: | 2023-10-06 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand
To Be Published
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8QRA
 | | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand | | Descriptor: | (4~{R},5~{S},6~{S})-4,5,6,15,17-pentakis(oxidanyl)-2,12-dioxabicyclo[12.4.0]octadeca-1(14),15,17-triene-7,13-dione, Mitogen-activated protein kinase 1, SULFATE ION | | Authors: | Gelin, M, Labesse, G. | | Deposit date: | 2023-10-06 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand
To Be Published
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8QRC
 | | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand | | Descriptor: | (5~{S},6~{S},8~{R},11~{S})-8-fluoranyl-11-methyl-5,6,15,17-tetrakis(oxidanyl)-2,12-dioxabicyclo[12.4.0]octadeca-1(14),15,17-triene-7,13-dione, Mitogen-activated protein kinase 1, SULFATE ION | | Authors: | Gelin, M, Labesse, G. | | Deposit date: | 2023-10-06 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand
To Be Published
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1KMQ
 | | Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L) | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Longenecker, K, Read, P, Lin, S.-K, Somlyo, A.P, Nakamoto, R.K, Derewenda, Z.S. | | Deposit date: | 2001-12-17 | | Release date: | 2003-05-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution.
Acta Crystallogr.,Sect.D, 59, 2003
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5JHG
 | | Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11 | | Descriptor: | GLYCEROL, Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | | Authors: | Wang, R, Chen, Q, Zhang, H, Yan, Z, Li, J, Miao, L, Wang, F. | | Deposit date: | 2016-04-21 | | Release date: | 2017-04-26 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11
To Be Published
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4U86
 | | Human Pin1 with cysteine sulfonic acid 113 | | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | Authors: | Li, W, Zhang, Y. | | Deposit date: | 2014-08-01 | | Release date: | 2015-04-08 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease.
Neurobiol.Dis., 76, 2015
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6EKL
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8I53
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8I0N
 | | Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 (Local refine) | | Descriptor: | Beta-arrestin-1, C5a anaphylatoxin chemotactic receptor 1, Fab30 heavy chain, ... | | Authors: | Maharana, J, Sarma, P, Yadav, M.K, Banerjee, R, Shukla, A.K. | | Deposit date: | 2023-01-11 | | Release date: | 2023-05-17 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structural snapshots uncover a key phosphorylation motif in GPCRs driving beta-arrestin activation.
Mol.Cell, 83, 2023
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5XOJ
 | | Crystal structure of Xpo1p-PKI-Nup42p-Gsp1p-GTP complex | | Descriptor: | Exportin-1, GTP-binding nuclear protein, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Koyama, M, Shirai, N, Matsuura, Y. | | Deposit date: | 2017-05-29 | | Release date: | 2017-08-16 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the Xpo1p nuclear export complex bound to the SxFG/PxFG repeats of the nucleoporin Nup42p
Genes Cells, 22, 2017
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7FIK
 | | The cryo-EM structure of the CR subunit from X. laevis NPC | | Descriptor: | MGC154553 protein, MGC83295 protein, MGC83926 protein, ... | | Authors: | Shi, Y, Huang, G, Zhan, X. | | Deposit date: | 2021-07-31 | | Release date: | 2022-11-09 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex.
Science, 376, 2022
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6LK8
 | | Structure of Xenopus laevis Cytoplasmic Ring subunit. | | Descriptor: | GATOR complex protein SEC13, MGC154553 protein, MGC83295 protein, ... | | Authors: | Shi, Y, Huang, G, Yan, C, Zhang, Y. | | Deposit date: | 2019-12-18 | | Release date: | 2021-07-21 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis.
Cell Res., 30, 2020
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8QZ0
 | | SWR1-hexasome-dimer complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP6, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Jalal, A.S.B, Wigley, D.B. | | Deposit date: | 2023-10-26 | | Release date: | 2024-10-02 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Stabilization of the hexasome intermediate during histone exchange by yeast SWR1 complex.
Mol.Cell, 84, 2024
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2ILK
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6RO4
 | | Structure of the core TFIIH-XPA-DNA complex | | Descriptor: | DNA repair protein complementing XP-A cells, DNA1, DNA2, ... | | Authors: | Kokic, G, Chernev, A, Tegunov, D, Dienemann, C, Urlaub, H, Cramer, P. | | Deposit date: | 2019-05-10 | | Release date: | 2019-07-03 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis of TFIIH activation for nucleotide excision repair.
Nat Commun, 10, 2019
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3JZH
 | | EED-H3K79me3 | | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | | Authors: | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-09-23 | | Release date: | 2009-12-15 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
Proc.Natl.Acad.Sci.USA, 107, 2010
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8B8T
 | | Open conformation of the complex of DNA ligase I on PCNA and DNA in the presence of ATP | | Descriptor: | DNA ligase 1, Proliferating cell nuclear antigen | | Authors: | Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. | | Deposit date: | 2022-10-05 | | Release date: | 2023-01-11 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
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5CXR
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4CNI
 | | Crystal structure of the Fab portion of Olokizumab in complex with IL- 6 | | Descriptor: | INTERLEUKIN-6, OLOKIZUMAB HEAVY CHAIN, FAB PORTION, ... | | Authors: | Shaw, S, Bourne, T, Meier, C, Carrington, B, Gelinas, R, Henry, A, Popplewell, A, Adams, R, Baker, T, Rapecki, S, Marshall, D, Neale, H, Lawson, A. | | Deposit date: | 2014-01-22 | | Release date: | 2014-04-30 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling.
Mabs, 6, 2014
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7OH9
 | | Nucleosome with TBP and TFIIA bound at SHL -6 | | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Wang, H, Cramer, P. | | Deposit date: | 2021-05-09 | | Release date: | 2021-07-28 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures and implications of TBP-nucleosome complexes.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7OHB
 | | TBP-nucleosome complex | | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Wang, H, Cramer, P. | | Deposit date: | 2021-05-10 | | Release date: | 2021-07-28 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures and implications of TBP-nucleosome complexes.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7NXZ
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