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1CIS	CONTEXT DEPENDENCE OF PROTEIN SECONDARY STRUCTURE FORMATION. THE THREE-DIMENSIONAL STRUCTURE AND STABILITY OF A HYBRID BETWEEN CHYMOTRYPSIN INHIBITOR 2 AND HELIX E FROM SUBTILISIN CARLSBERG Descriptor: HYBRID PROTEIN FORMED FROM CHYMOTRYPSIN INHIBITOR-2 Authors: Osmark, P, Sorensen, P, Poulsen, F.M. Deposit date: 1993-04-23 Release date: 1993-10-31 Last modified: 2024-04-10 Method: SOLUTION NMR Cite: Context dependence of protein secondary structure formation: the three-dimensional structure and stability of a hybrid between chymotrypsin inhibitor 2 and helix E from subtilisin Carlsberg. Biochemistry, 32, 1993
1TM7	crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 M59Y mutant Descriptor: CALCIUM ION, CITRIC ACID, PENTAETHYLENE GLYCOL, ... Authors: Radisky, E.S, Kwan, G, Karen Lu, C.J, Koshland Jr, D.E. Deposit date: 2004-06-10 Release date: 2004-11-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Binding, Proteolytic, and Crystallographic Analyses of Mutations at the Protease-Inhibitor Interface of the Subtilisin BPN'/Chymotrypsin Inhibitor 2 Complex(,). Biochemistry, 43, 2004
1TM4	crystal structure of the complex of subtilsin BPN'with chymotrypsin inhibitor 2 M59G mutant Descriptor: CALCIUM ION, CITRIC ACID, PENTAETHYLENE GLYCOL, ... Authors: Radisky, E.S, Kwan, G, Karen Lu, C.J, Koshland Jr, D.E. Deposit date: 2004-06-10 Release date: 2004-11-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Binding, Proteolytic, and Crystallographic Analyses of Mutations at the Protease-Inhibitor Interface of the Subtilisin BPN'/Chymotrypsin Inhibitor 2 Complex(,). Biochemistry, 43, 2004
1TM5	crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 M59A mutant Descriptor: CALCIUM ION, CITRIC ACID, PENTAETHYLENE GLYCOL, ... Authors: Radisky, E.S, Kwan, G, Karen Lu, C.J, Koshland Jr, D.E. Deposit date: 2004-06-10 Release date: 2004-11-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Binding, Proteolytic, and Crystallographic Analyses of Mutations at the Protease-Inhibitor Interface of the Subtilisin BPN'/Chymotrypsin Inhibitor 2 Complex(,). Biochemistry, 43, 2004
1TM1	CRYSTAL STRUCTURE OF THE COMPLEX OF SUBTILISIN BPN' WITH CHYMOTRYPSIN INHIBITOR 2 Descriptor: CALCIUM ION, CITRIC ACID, PENTAETHYLENE GLYCOL, ... Authors: Radisky, E.S, Kwan, G, Karen Lu, C.J, Koshland Jr, D.E. Deposit date: 2004-06-10 Release date: 2004-11-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Binding, Proteolytic, and Crystallographic Analyses of Mutations at the Protease-Inhibitor Interface of the Subtilisin BPN'/Chymotrypsin Inhibitor 2 Complex(,). Biochemistry, 43, 2004
1TM3	crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 M59k mutant Descriptor: CALCIUM ION, CITRIC ACID, PENTAETHYLENE GLYCOL, ... Authors: Radisky, E.S, Kwan, G, Karen Lu, C.J, Koshland Jr, D.E. Deposit date: 2004-06-10 Release date: 2004-11-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Binding, Proteolytic, and Crystallographic Analyses of Mutations at the Protease-Inhibitor Interface of the Subtilisin BPN'/Chymotrypsin Inhibitor 2 Complex(,). Biochemistry, 43, 2004
1TMG	crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 M59F mutant Descriptor: CALCIUM ION, CITRIC ACID, PENTAETHYLENE GLYCOL, ... Authors: Radisky, E.S, Kwan, G, Karen Lu, C.J, Koshland Jr, D.E. Deposit date: 2004-06-10 Release date: 2004-11-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Binding, Proteolytic, and Crystallographic Analyses of Mutations at the Protease-Inhibitor Interface of the Subtilisin BPN'/Chymotrypsin Inhibitor 2 Complex(,). Biochemistry, 43, 2004
1TO1	crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 Y61A mutant Descriptor: CALCIUM ION, CITRIC ACID, PENTAETHYLENE GLYCOL, ... Authors: Radisky, E.S, Kwan, G, Karen Lu, C.J, Koshland Jr, D.E. Deposit date: 2004-06-11 Release date: 2004-11-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Binding, Proteolytic, and Crystallographic Analyses of Mutations at the Protease-Inhibitor Interface of the Subtilisin BPN'/Chymotrypsin Inhibitor 2 Complex(,). Biochemistry, 43, 2004
1TO2	crystal structure of the complex of subtilisin BPN' with chymotrypsin inhibitor 2 M59K, in pH 9 cryosoak Descriptor: CALCIUM ION, CITRIC ACID, POLYETHYLENE GLYCOL (N=34), ... Authors: Radisky, E.S, Kwan, G, Karen Lu, C.J, Koshland Jr, D.E. Deposit date: 2004-06-11 Release date: 2004-11-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Binding, Proteolytic, and Crystallographic Analyses of Mutations at the Protease-Inhibitor Interface of the Subtilisin BPN'/Chymotrypsin Inhibitor 2 Complex(,). Biochemistry, 43, 2004
1PSI	Intact recombined alpha1-antitrypsin mutant PHE 51 to LEU Descriptor: ALPHA=1=-ANTITRYPSIN Authors: Abrahams, J.P, Elliott, P.R, Lomas, D.A, Carrell, R.W. Deposit date: 1996-06-11 Release date: 1996-12-07 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Inhibitory conformation of the reactive loop of alpha 1-antitrypsin. Nat.Struct.Biol., 3, 1996
1AS4	CLEAVED ANTICHYMOTRYPSIN A349R Descriptor: ACETATE ION, ANTICHYMOTRYPSIN Authors: Lukacs, C.M, Christianson, D.W. Deposit date: 1997-08-12 Release date: 1998-02-25 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction. Biochemistry, 37, 1998
1TPA	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS Descriptor: ANHYDRO-TRYPSIN, BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION Authors: Huber, R, Bode, W, Deisenhofer, J. Deposit date: 1982-09-27 Release date: 1983-01-18 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors Acta Crystallogr.,Sect.B, 39, 1983
1TPO	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS Descriptor: BETA-TRYPSIN, CALCIUM ION Authors: Bode, W, Walter, J, Huber, R. Deposit date: 1982-09-27 Release date: 1983-01-18 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors Acta Crystallogr.,Sect.B, 39, 1983
1TYN	ATOMIC STRUCTURE OF THE TRYPSIN-CYCLOTHEONAMIDE A COMPLEX: LESSONS FOR THE DESIGN OF SERINE PROTEASE INHIBITORS Descriptor: BETA-TRYPSIN, CYCLOTHEONAMIDE A Authors: Lee, A.Y, Hagihara, M, Karmacharya, R, Albers, M.W, Schreiber, S.L, Clardy, J. Deposit date: 1994-09-19 Release date: 1995-01-26 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Atomic Structure of the Trypsin-Cyclotheonamide a Complex: Lessons for the Design of Serine Protease Inhibitors J.Am.Chem.Soc., 115, 1993
5DKM	S. erythraea trypsin Michaelis-Menten complex Descriptor: Trypsin Authors: Blankenship, E, Lodowski, D.T. Deposit date: 2015-09-03 Release date: 2017-03-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (0.92 Å) Cite: High resolution structures of S. erythraeus trypsin throughout the catalytic cycle To be Published
5DJ7	S. erythraea trypsin acyl-enzyme Descriptor: Trypsin Authors: Blankenship, E, Lodowski, D.T. Deposit date: 2015-09-01 Release date: 2017-03-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (0.87 Å) Cite: High resolution structures of S. erythraeus trypsin throughout the catalytic cycle To be Published
5DK1	S. erythraea trypsin mixed catalytic intermediate Descriptor: Trypsin Authors: Blankenship, E, Lodowski, D.T. Deposit date: 2015-09-02 Release date: 2017-03-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (0.938 Å) Cite: High resolution structures of S. erythraeus trypsin throughout the catalytic cycle To be Published
5KWM	S. erythraea trypsin long construct apoenzyme Descriptor: Trypsin Authors: Blankenship, E, Lodowski, D.T. Deposit date: 2016-07-18 Release date: 2017-10-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (0.777 Å) Cite: S. erythraea trypsin long construct To be Published
4PTI	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS Descriptor: TRYPSIN INHIBITOR Authors: Huber, R, Kukla, D, Ruehlmann, A, Epp, O, Formanek, H, Deisenhofer, J, Steigemann, W. Deposit date: 1982-09-27 Release date: 1983-01-18 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors Acta Crystallogr.,Sect.B, 39, 1983
5JBT	Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2) Descriptor: Amyloid-like protein 2, CALCIUM ION, PRSS3 protein, ... Authors: Kayode, O, Wang, R, Pendlebury, D, Soares, A, Radisky, E.S. Deposit date: 2016-04-13 Release date: 2016-11-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis. J. Biol. Chem., 291, 2016
2PTC	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS Descriptor: BETA-TRYPSIN, CALCIUM ION, TRYPSIN INHIBITOR Authors: Huber, R, Deisenhofer, J. Deposit date: 1982-09-27 Release date: 1983-01-18 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors Acta Crystallogr.,Sect.B, 39, 1983
5H1H	NMR structure of SLBA, a chimera of SFTI Descriptor: Bradykinin-trypsin inhibitor secondary loop chimera Authors: Xiao, T, Tam, J.P. Deposit date: 2016-10-10 Release date: 2017-04-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: An Orally Active Bradykinin B1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor. J. Med. Chem., 60, 2017
5H1I	NMR structure of TIBA, a chimera of SFTI Descriptor: Bradykinin-trypsin inhibitor secondary loop chimera Authors: Xiao, T, Tam, J.P. Deposit date: 2016-10-10 Release date: 2017-04-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: An Orally Active Bradykinin B1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor. J. Med. Chem., 60, 2017
5J4S	alpha-chymotrypsin from bovine pancreas in complex with a modified Bowman-Birk inhibitor from soybean Descriptor: Bowman-Birk type proteinase inhibitor, Chymotrypsinogen A Authors: Johansson, E, Tornoee, C.W. Deposit date: 2016-04-01 Release date: 2017-04-12 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.103 Å) Cite: Divergent Protein Synthesis of Bowman-Birk Protease Inhibitors, their Hydrodynamic Behavior and Co-crystallization with alpha-Chymotrypsin Synlett, 2017
5J4Q	alpha-chymotrypsin from bovine pancreas in complex with Bowman-Birk inhibitor from soybean Descriptor: Bowman-Birk type proteinase inhibitor, Chymotrypsinogen A Authors: Johansson, E, Tornoee, C.W. Deposit date: 2016-04-01 Release date: 2017-04-12 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.303 Å) Cite: Divergent Protein Synthesis of Bowman-Birk Protease Inhibitors, their Hydrodynamic Behavior and Co-crystallization with alpha-Chymotrypsin Synlett, 2017

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