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8SOE	Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOD	Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOC	Phosphoinositide phosphate 3 kinase gamma bound with ADP and Gbetagamma Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8W9A	CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site Descriptor: 6-chloranyl-3-[[(1R)-1-[2-(1,3-dihydropyrrolo[3,4-c]pyridin-2-yl)-3,6-dimethyl-4-oxidanylidene-quinazolin-8-yl]ethyl]amino]pyridine-2-carboxylic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Huang, X, Ren, X, Zhong, W. Deposit date: 2023-09-05 Release date: 2024-04-17 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Cryo-EM structures reveal two allosteric inhibition modes of PI3K alpha H1047R involving a re-shaping of the activation loop. Structure, 2024
8W9B	CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-8557 binding at an allosteric site Descriptor: 1-[(1S)-1-(5-fluoranyl-3-methyl-1-benzofuran-2-yl)-2-methyl-propyl]-3-(1-oxidanylidene-2,3-dihydroisoindol-5-yl)urea, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Huang, X, Ren, X, Zhong, W. Deposit date: 2023-09-05 Release date: 2024-04-17 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3 Å) Cite: Cryo-EM structures reveal two allosteric inhibition modes of PI3K alpha H1047R involving a re-shaping of the activation loop. Structure, 2024

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