PDB: 38 resultsInfo pagesStatus searchChemie searchBIRD

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2RRA	Solution structure of RNA binding domain in human Tra2 beta protein in complex with RNA (GAAGAA) Descriptor: 5'-R(*GP*AP*AP*GP*AP*A)-3', cDNA FLJ40872 fis, clone TUTER2000283, ... Authors: Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Sugano, S, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2010-06-17 Release date: 2011-04-27 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM. Nucleic Acids Res., 39, 2011
2RRB	Refinement of RNA binding domain in human Tra2 beta protein Descriptor: cDNA FLJ40872 fis, clone TUTER2000283, highly similar to Homo sapiens transformer-2-beta (SFRS10) gene Authors: Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Sugano, S, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2010-06-17 Release date: 2011-04-27 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM. Nucleic Acids Res., 39, 2011
3BLA	Synthetic Gene Encoded DcpS bound to inhibitor DG153249 Descriptor: 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS Authors: Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) Deposit date: 2007-12-10 Release date: 2008-10-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
3BL9	Synthetic Gene Encoded DcpS bound to inhibitor DG157493 Descriptor: 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS Authors: Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) Deposit date: 2007-12-10 Release date: 2008-10-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
3BL7	Synthetic Gene Encoded DcpS bound to inhibitor DG156844 Descriptor: 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS Authors: Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) Deposit date: 2007-12-10 Release date: 2008-10-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.31 Å) Cite: DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
5XJS	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2/F/E from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Yi, H, Zhang, R. Deposit date: 2017-05-04 Release date: 2018-07-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.38 Å) Cite: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly. Nucleic Acids Res., 2019
5XJT	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2.R61A/F/E/G from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Yi, H, Zhang, R. Deposit date: 2017-05-04 Release date: 2018-07-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Structures of 7S mutant complexes To Be Published
5XJR	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2/F/E/G from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Yi, H, Zhang, R. Deposit date: 2017-05-04 Release date: 2018-07-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.12 Å) Cite: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly. Nucleic Acids Res., 2019
5XJL	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1/D2/F/E/G from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Zhang, R. Deposit date: 2017-05-02 Release date: 2018-05-02 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly Cell, 146, 2011
5XJU	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2.R61A/F/E/G from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Yi, H, Zhang, R. Deposit date: 2017-05-04 Release date: 2018-07-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Structures of 7S mutant complexes. To Be Published
5XJQ	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2/F/E/G from Human Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... Authors: Yi, H, Zhang, R. Deposit date: 2017-05-04 Release date: 2018-07-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.28 Å) Cite: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly. Nucleic Acids Res., 2019
7W2P	Tudor domain of SMN in complex with a small molecule Descriptor: 2-[(4-fluorophenyl)methyl]-2-azatricyclo[7.3.0.0^{3,7}]dodeca-1(9),3(7)-dien-8-imine, MAGNESIUM ION, Survival motor neuron protein, ... Authors: Li, W, Arrowsmith, C.H, Edwards, A.M, Liu, Y, Min, J. Deposit date: 2021-11-24 Release date: 2022-10-05 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.15 Å) Cite: A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun, 13, 2022
7W30	Tudor domain of SMN in complex with a small molecule Descriptor: 1,2-dimethylquinolin-4-imine, Survival motor neuron protein, UNKNOWN ATOM OR ION Authors: Li, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Liu, Y, Min, J. Deposit date: 2021-11-24 Release date: 2022-10-05 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun, 13, 2022

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