6VEM
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![BU of 6vem by Molmil](/molmil-images/mine/6vem) | Structure of RNA octamer | Descriptor: | COBALT HEXAMMINE(III), Modified Octamer RNA | Authors: | Pallan, P.S, Egli, M. | Deposit date: | 2020-01-02 | Release date: | 2020-11-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine. Nucleic Acids Res., 48, 2020
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6VG7
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6MLU
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![BU of 6mlu by Molmil](/molmil-images/mine/6mlu) | Cryo-EM structure of lipid droplet formation protein Seipin/BSCL2 | Descriptor: | Seipin | Authors: | Sui, X, Arlt, H, Liao, M, Walther, C.T, Farese, V.R. | Deposit date: | 2018-09-28 | Release date: | 2018-10-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. J. Cell Biol., 217, 2018
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6MO5
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![BU of 6mo5 by Molmil](/molmil-images/mine/6mo5) | Co-Crystal structure of P. aeruginosa LpxC-50228 complex | Descriptor: | MAGNESIUM ION, N-[(2S)-1-(hydroxyamino)-3-methyl-3-{[(oxetan-3-yl)methyl]sulfonyl}-1-oxobutan-2-yl]-4-(6-hydroxyhexa-1,3-diyn-1-yl)benzamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase | Authors: | Stein, A.J, Holt, M.C, Assar, Z, Cohen, F, Andrews, L, Cirz, R. | Deposit date: | 2018-10-04 | Release date: | 2019-07-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.851 Å) | Cite: | Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety. Chemmedchem, 14, 2019
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6V79
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![BU of 6v79 by Molmil](/molmil-images/mine/6v79) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2376 | Descriptor: | 1,2-ETHANEDIOL, 4-{[(2S)-3,3-dimethyl-2-(pyridin-3-yl)-2,3-dihydro-1H-indol-1-yl]methyl}-N-hydroxybenzamide, Hdac6 protein, ... | Authors: | Osko, J.D, Christianson, D.W. | Deposit date: | 2019-12-08 | Release date: | 2020-12-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.03951526 Å) | Cite: | Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. J.Med.Chem., 64, 2021
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7C09
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6V0L
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![BU of 6v0l by Molmil](/molmil-images/mine/6v0l) | PDGFR-b Promoter Forms a G-Vacancy Quadruplex that Can be Complemented by dGMP: Molecular Structure and Recognition of Guanine Derivatives and Metabolites | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*(3D1)P*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*GP*CP*GP*GP*GP*AP*CP*A)-3') | Authors: | Wang, K.B, Dickerhoff, J, Wu, G, Yang, D. | Deposit date: | 2019-11-18 | Release date: | 2020-03-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | PDGFR-beta Promoter Forms a Vacancy G-Quadruplex that Can Be Filled in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs. J.Am.Chem.Soc., 142, 2020
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6V2F
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![BU of 6v2f by Molmil](/molmil-images/mine/6v2f) | Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor, GS-6207 | Descriptor: | HIV-1 capsid, N-[(1S)-1-(3-{4-chloro-3-[(methylsulfonyl)amino]-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl}-6-[3-methyl-3-(methylsulfonyl)but-1-yn-1-yl]pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl]-2-[(3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide | Authors: | Appleby, T.C, Link, J.O, Yant, S.R, Villasenor, A.G, Somoza, J.R, Hu, E.Y, Schroeder, S.D, Cihlar, T. | Deposit date: | 2019-11-22 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Clinical targeting of HIV capsid protein with a long-acting small molecule. Nature, 584, 2020
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1FIV
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![BU of 1fiv by Molmil](/molmil-images/mine/1fiv) | STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS | Descriptor: | FIV PROTEASE, FIV PROTEASE INHIBITOR ACE-ALN-VAL-STA-GLU-ALN-NH2 | Authors: | Wlodawer, A, Gustchina, A, Reshetnikova, L, Lubkowski, J, Zdanov, A. | Deposit date: | 1995-05-04 | Release date: | 1995-07-31 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus. Nat.Struct.Biol., 2, 1995
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6MRY
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![BU of 6mry by Molmil](/molmil-images/mine/6mry) | NoD173 plant defensin | Descriptor: | 1,2-ETHANEDIOL, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, CHLORIDE ION, ... | Authors: | Caria, S, Kvansakul, M. | Deposit date: | 2018-10-15 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and functional characterization of the membrane-permeabilizing activity ofNicotiana occidentalisdefensin NoD173 and protein engineering to enhance oncolysis. Faseb J., 33, 2019
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1FJ1
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6MX8
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![BU of 6mx8 by Molmil](/molmil-images/mine/6mx8) | Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib | Descriptor: | 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine, ALK tyrosine kinase receptor | Authors: | Dougan, D.R, Zhou, T. | Deposit date: | 2018-10-30 | Release date: | 2018-12-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase. J. Med. Chem., 59, 2016
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6MW5
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![BU of 6mw5 by Molmil](/molmil-images/mine/6mw5) | UDP-galactose:glucoside-Skp1 alpha-D-galactosyltransferase with bound UDP and Platinum | Descriptor: | 1,2-ETHANEDIOL, PLATINUM (II) ION, UDP-galactose:glucoside-Skp1 alpha-D-galactosyltransferase, ... | Authors: | Kim, H.W, Wood, Z.A, West, C.M. | Deposit date: | 2018-10-29 | Release date: | 2019-10-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A terminal alpha 3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii . J.Biol.Chem., 295, 2020
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7BWM
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1FRH
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7BNT
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![BU of 7bnt by Molmil](/molmil-images/mine/7bnt) | Complex of rice blast (Magnaporthe oryzae) effector protein AVR-PikD with a predicted ancestral HMA domain of Pik-1 from Oryza spp. | Descriptor: | 1,2-ETHANEDIOL, AVR-Pik protein, Predicted ancestral HMA domain of Pik-1 from Oryza spp. | Authors: | Bialas, A, Langner, T, Harant, A, Contreras, M.P, Stevenson, C.E.M, Lawson, D.M, Sklenar, J, Kellner, R, Moscou, M.J, Terauchi, R, Banfield, M.J, Kamoun, S. | Deposit date: | 2021-01-22 | Release date: | 2021-02-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain. Elife, 10, 2021
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6N76
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6MW7
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![BU of 6mw7 by Molmil](/molmil-images/mine/6mw7) | Crystal structure of ATPase module of SMCHD1 bound to ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SODIUM ION, ... | Authors: | Pedersen, L.C, Inoue, K, Kim, S, Perera, L, Shaw, N.D. | Deposit date: | 2018-10-29 | Release date: | 2019-09-11 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.194 Å) | Cite: | A ubiquitin-like domain is required for stabilizing the N-terminal ATPase module of human SMCHD1. Commun Biol, 2, 2019
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7BD7
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6VEB
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![BU of 6veb by Molmil](/molmil-images/mine/6veb) | Precorrin-2-bound S128A S. typhimurium siroheme synthase | Descriptor: | 3,3',3'',3'''-[(7S,8S,12S,13S)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-7,8,12,13,20,24-hexahydroporphyrin-2,7,1 2,18-tetrayl]tetrapropanoic acid, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Pennington, J.M, Stroupe, M.E. | Deposit date: | 2019-12-31 | Release date: | 2020-03-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun, 11, 2020
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6N2I
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![BU of 6n2i by Molmil](/molmil-images/mine/6n2i) | Lon protease AAA+ domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA-binding ATP-dependent protease La | Authors: | Botos, I, Li, M, Wlodawer, A, Gustchina, A. | Deposit date: | 2018-11-13 | Release date: | 2019-07-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | New insights into structural and functional relationships between LonA proteases and ClpB chaperones. Febs Open Bio, 9, 2019
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7BEA
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![BU of 7bea by Molmil](/molmil-images/mine/7bea) | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor | Descriptor: | 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine, Programmed cell death 1 ligand 1 | Authors: | Magiera-Mularz, K, Butera, R, Wazynska, M, Holak, T, Domling, A. | Deposit date: | 2020-12-22 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists. Acs Med.Chem.Lett., 12, 2021
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1F8V
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![BU of 1f8v by Molmil](/molmil-images/mine/1f8v) | THE STRUCTURE OF PARIACOTO VIRUS REVEALS A DODECAHEDRAL CAGE OF DUPLEX RNA | Descriptor: | CALCIUM ION, MATURE CAPSID PROTEIN BETA, MATURE CAPSID PROTEIN GAMMA, ... | Authors: | Tang, L, Johnson, K.N, Ball, L.A, Lin, T, Yeager, M, Johnson, J.E. | Deposit date: | 2000-07-05 | Release date: | 2000-12-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structure of pariacoto virus reveals a dodecahedral cage of duplex RNA. Nat.Struct.Biol., 8, 2001
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1FRJ
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6VGA
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