PDB: 452 resultsInfo pagesStatus searchChemie searchBIRD

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8VJK	Structure of mouse RyR1 (high-Ca2+/CFF/ATP dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-07 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (2.92 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. To Be Published
8UXG	Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.08 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXI	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.29 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXE	Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXM	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXF	Structure of PKA phosphorylated human RyR2-R420W in the primed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXC	Structure of PKA phosphorylated human RyR2-R420Q in the primed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXH	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXL	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
3UF8	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with a G95A surface mutation from Burkholderia pseudomallei complexed with FK506 Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-10-31 Release date: 2011-11-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
4FN2	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37 Descriptor: Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase, ethyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-06-19 Release date: 2012-08-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
5KLX	Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 Descriptor: 2-[(2~{S})-1-(phenylmethyl)sulfonylpiperidin-2-yl]carbonyloxyethyl pyridine-3-carboxylate, Chimera protein of Ubiquitin-like protein SMT3 and Peptidyl-prolyl cis-trans isomerase, DI(HYDROXYETHYL)ETHER, ... Authors: Fox III, D, Edwards, T.E. Deposit date: 2016-06-26 Release date: 2017-05-31 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 To Be Published
8VK3	Structure of mouse RyR1 in complex with S100A1 (EGTA-only dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Peptidyl-prolyl cis-trans isomerase FKBP1A, Protein S100A1, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-08 Release date: 2024-01-24 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Structural insights into the regulation of RyR1 by S100A1 To Be Published
8VK4	Structure of mouse RyR1 in complex with S100A1 (high-Ca2+/CFF/ATP dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-08 Release date: 2024-02-07 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. To Be Published
6O4A	CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF355 Descriptor: 2-(pyridin-3-ylcarbonylamino)ethyl (2~{S})-1-(phenylmethyl)sulfonylpiperidine-2-carboxylate, CALCIUM ION, Ubiquitin-like protein SMT3,Peptidyl-prolyl cis-trans isomerase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2019-02-28 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF355 to be published
3VAW	Crystal structure of a smt fusion peptidyl-prolyl cis-trans isomerase with surface mutation v3i from burkholderia pseudomallei complexed with fk506 Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3,Peptidyl-prolyl cis-trans isomerase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-12-29 Release date: 2012-01-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
3UQA	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation A54E from Burkholderia pseudomallei complexed with FK506 Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-11-19 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
3UQB	Crystal structure of a SMT Fusion PEPTIDYL-PROLYL CIS-TRANS ISOMERASE with surface mutation D44G from Burkholderia pseudomallei complexed with FK506 Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-11-19 Release date: 2011-11-30 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
6O49	CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF339 Descriptor: (2~{S})-~{N}-[3-oxidanylidene-3-[(3,4,5-trimethoxyphenyl)amino]propyl]-1-(phenylmethyl)sulfonyl-piperidine-2-carboxamide, 1,2-ETHANEDIOL, CALCIUM ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2019-02-28 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.85 Å) Cite: CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF339 to be published
5B8I	Crystal structure of Calcineurin A and Calcineurin B in complex with FKBP12 and FK506 from Coccidioides immitis RS Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D, Dranow, D.M, Lorimer, D.D, Edwards, T.E. Deposit date: 2015-05-03 Release date: 2015-05-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nat Commun, 10, 2019
1TCO	TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS) Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, FE (III) ION, ... Authors: Griffith, J.P, Kim, J.L, Kim, E.E, Sintchak, M.D, Thomson, J.A, Fitzgibbon, M.J, Fleming, M.A, Caron, P.R, Hsiao, K, Navia, M.A. Deposit date: 1996-08-21 Release date: 1997-02-12 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.5 Å) Cite: X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell(Cambridge,Mass.), 82, 1995
4G50	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ168 Descriptor: 1,2-ETHANEDIOL, 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate, FORMIC ACID, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-07-17 Release date: 2012-08-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
4GGQ	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 Descriptor: 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-08-07 Release date: 2012-08-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
4GIV	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183 Descriptor: 3-(pyridin-3-yl)propyl (2S)-1-[(3-nitrophenyl)sulfonyl]piperidine-2-carboxylate, FORMIC ACID, Ubiquitin-like protein SMT3, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-08-09 Release date: 2012-09-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.45 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
7L7I	Cryo-EM structure of Hsp90:FKBP51:p23 closed-state complex Descriptor: Heat shock protein HSP 90-alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Peptidyl-prolyl cis-trans isomerase FKBP5, ... Authors: Lee, K, Thwin, A.C, Tse, E, Gates, S.N, Southworth, D.R. Deposit date: 2020-12-28 Release date: 2021-08-25 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state. Mol.Cell, 81, 2021

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