7AUJ
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![BU of 7auj by Molmil](/molmil-images/mine/7auj) | Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 mutation E80Q in complex with 1-InsP7 | Descriptor: | (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, Diphosphoinositol polyphosphate phosphohydrolase DDP1, MAGNESIUM ION | Authors: | Marquez-Monino, M.A, Gonzalez, B. | Deposit date: | 2020-11-03 | Release date: | 2021-05-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Multiple substrate recognition by yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase through phosphate clamping. Sci Adv, 7, 2021
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7AUQ
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7AUI
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7AUS
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2G01
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![BU of 2g01 by Molmil](/molmil-images/mine/2g01) | Pyrazoloquinolones as Novel, Selective JNK1 inhibitors | Descriptor: | 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE, C-jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, ... | Authors: | Abad-Zapatero, C. | Deposit date: | 2006-02-10 | Release date: | 2006-04-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
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6K4D
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![BU of 6k4d by Molmil](/molmil-images/mine/6k4d) | Ancestral luciferase AncLamp in complex with ATP and D-luciferin | Descriptor: | (4S)-2-(6-hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid, Ancestral luciferase AncLamp, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (4S)-2-(6-oxidanyl-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate | Authors: | Oba, Y, Konishi, K, Yano, D, Kato, D, Shirai, T. | Deposit date: | 2019-05-23 | Release date: | 2020-05-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Resurrecting the ancient glow of the fireflies. Sci Adv, 6, 2020
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6K4C
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![BU of 6k4c by Molmil](/molmil-images/mine/6k4c) | Ancestral luciferase AncLamp in complex with DLSA | Descriptor: | 5'-O-[N-(DEHYDROLUCIFERYL)-SULFAMOYL] ADENOSINE, Ancestral luciferase AncLamp, MAGNESIUM ION | Authors: | Oba, Y, Konishi, K, Yano, D, Kato, D, Shirai, T. | Deposit date: | 2019-05-23 | Release date: | 2020-05-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Resurrecting the ancient glow of the fireflies. Sci Adv, 6, 2020
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2H96
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![BU of 2h96 by Molmil](/molmil-images/mine/2h96) | Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors | Descriptor: | 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE, C-jun-amino-terminal kinase-interacting protein 1, GLYCEROL, ... | Authors: | Abad-Zapatero, C. | Deposit date: | 2006-06-09 | Release date: | 2006-07-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors. J.Med.Chem., 49, 2006
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2NO3
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![BU of 2no3 by Molmil](/molmil-images/mine/2no3) | Novel 4-anilinopyrimidines as potent JNK1 Inhibitors | Descriptor: | 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE, C-JUN-AMINO-TERMINAL KINASE-INTERACTING protein 1, Mitogen-activated protein kinase 8, ... | Authors: | Abad-Zapatero, C. | Deposit date: | 2006-10-24 | Release date: | 2007-04-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg.Med.Chem.Lett., 17, 2007
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2GMX
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![BU of 2gmx by Molmil](/molmil-images/mine/2gmx) | Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity | Descriptor: | C-jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE, ... | Authors: | Abad-Zapatero, C. | Deposit date: | 2006-04-07 | Release date: | 2006-06-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity. J.Med.Chem., 49, 2006
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3O2M
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3NEW
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![BU of 3new by Molmil](/molmil-images/mine/3new) | p38-alpha complexed with Compound 10 | Descriptor: | 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, Mitogen-activated protein kinase 14 | Authors: | Goedken, E.R, Comess, K.M, Sun, C, Argiriadi, M, Jia, Y, Quinn, C.M, Banach, D.L, Marcotte, D, Borhani, D. | Deposit date: | 2010-06-09 | Release date: | 2010-12-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases. Acs Chem.Biol., 6, 2011
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3O17
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![BU of 3o17 by Molmil](/molmil-images/mine/3o17) | Crystal Structure of JNK1-alpha1 isoform | Descriptor: | C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE, ... | Authors: | Abad-Zapatero, C. | Deposit date: | 2010-07-20 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal Structure of JNK1-alpha1 isoform TO BE PUBLISHED
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6DJY
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![BU of 6djy by Molmil](/molmil-images/mine/6djy) | Fako virus | Descriptor: | Clamp protein, Major capsid protein, Turret protein | Authors: | Kaelber, J.T, Jiang, W, Weaver, S.C, Auguste, A.J, Chiu, W. | Deposit date: | 2018-05-27 | Release date: | 2019-06-05 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | The polymerase organization of Fako virus To be Published
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8FJL
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![BU of 8fjl by Molmil](/molmil-images/mine/8fjl) | Golden Shiner Reovirus Core Tropical Vertex | Descriptor: | Clamp protein VP6, Major inner capsid protein VP3, Microtubule-associated protein VP5, ... | Authors: | Stevens, A.S, Zhou, Z.H. | Deposit date: | 2022-12-19 | Release date: | 2023-03-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation. Protein Cell, 14, 2023
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8FJK
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![BU of 8fjk by Molmil](/molmil-images/mine/8fjk) | Golden Shiner Reovirus Core Polar Vertex | Descriptor: | Clamp protein VP6, Major inner capsid protein VP3, Microtubule-associated protein VP5, ... | Authors: | Stevens, A.S, Zhou, Z.H. | Deposit date: | 2022-12-19 | Release date: | 2023-03-22 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation. Protein Cell, 14, 2023
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6DJK
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6DJ8
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6PSN
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![BU of 6psn by Molmil](/molmil-images/mine/6psn) | Anthrax toxin protective antigen channels bound to lethal factor | Descriptor: | CALCIUM ION, Lethal factor, Protective antigen | Authors: | Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A. | Deposit date: | 2019-07-12 | Release date: | 2020-03-04 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun, 11, 2020
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5M1S
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![BU of 5m1s by Molmil](/molmil-images/mine/5m1s) | Cryo-EM structure of the E. coli replicative DNA polymerase-clamp-exonuclase-theta complex bound to DNA in the editing mode | Descriptor: | DNA Primer Strand, DNA Template Strand, DNA polymerase III subunit alpha, ... | Authors: | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | Deposit date: | 2016-10-10 | Release date: | 2017-01-18 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Self-correcting mismatches during high-fidelity DNA replication. Nat. Struct. Mol. Biol., 24, 2017
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3J9C
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![BU of 3j9c by Molmil](/molmil-images/mine/3j9c) | CryoEM single particle reconstruction of anthrax toxin protective antigen pore at 2.9 Angstrom resolution | Descriptor: | CALCIUM ION, Protective antigen PA-63 | Authors: | Jiang, J, Pentelute, B.L, Collier, R.J, Zhou, Z.H. | Deposit date: | 2014-12-25 | Release date: | 2015-03-11 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Atomic structure of anthrax protective antigen pore elucidates toxin translocation. Nature, 521, 2015
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6WJJ
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![BU of 6wjj by Molmil](/molmil-images/mine/6wjj) | Anthrax octamer prechannel bound to full-length lethal factor | Descriptor: | CALCIUM ION, Lethal factor, Protective antigen, ... | Authors: | Zhou, K, Hardenbrook, N.J, Liu, S, Cui, Y.X, Krantz, B.A, Zhou, Z.H. | Deposit date: | 2020-04-13 | Release date: | 2020-12-16 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Atomic Structures of Anthrax Prechannel Bound with Full-Length Lethal and Edema Factors. Structure, 28, 2020
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3KWV
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6UZB
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![BU of 6uzb by Molmil](/molmil-images/mine/6uzb) | Anthrax toxin protective antigen channels bound to edema factor | Descriptor: | CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen | Authors: | Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A. | Deposit date: | 2019-11-14 | Release date: | 2020-03-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun, 11, 2020
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6UZE
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![BU of 6uze by Molmil](/molmil-images/mine/6uze) | Anthrax toxin protective antigen channels bound to edema factor | Descriptor: | CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen | Authors: | Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A. | Deposit date: | 2019-11-15 | Release date: | 2020-03-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun, 11, 2020
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