PDB: 81162 resultsInfo pagesStatus searchChemie searchBIRD

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7EXY	T-hairpin structure found in the RNA element involved in the piRNA biogenesis Descriptor: RNA (5'-R(*UP*UP*GP*GP*UP*UP*UP*GP*AP*UP*UP*CP*CP*AP*AP*G)-3') Authors: Takase, N, Kawai, G. Deposit date: 2021-05-29 Release date: 2022-03-02 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: T-hairpin structure found in the RNA element involved in piRNA biogenesis. Rna, 28, 2022
5W6M	Crystal structure of the human histidyl-tRNA synthetase mutant D175E Descriptor: Histidine--tRNA ligase, cytoplasmic Authors: Blocquel, D, Yang, X.L. Deposit date: 2017-06-16 Release date: 2018-06-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.696 Å) Cite: CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells. Proc.Natl.Acad.Sci.USA, 2019
6YKQ	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11c Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKX	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11j Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKN	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11b Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKW	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11h Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKO	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11a Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKT	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11e Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKK	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 15 Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.236 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKV	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11g Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKS	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11d Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKL	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11k Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKU	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11f Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-04-06 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
7A0P	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11i Descriptor: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... Authors: Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2020-08-10 Release date: 2020-12-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
1B8A	ASPARTYL-TRNA SYNTHETASE Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PROTEIN (ASPARTYL-TRNA SYNTHETASE) Authors: Schmitt, E, Moulinier, L, Thierry, J.-C, Moras, D. Deposit date: 1999-01-27 Release date: 1999-02-02 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation. EMBO J., 17, 1998
5YJL	Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with NADPH and GBP Descriptor: Glutamyl-tRNA reductase 1, Glutamyl-tRNA reductase-binding protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Zhao, A, Han, F. Deposit date: 2017-10-11 Release date: 2018-05-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of Arabidopsis thaliana glutamyl-tRNAGlureductase in complex with NADPH and glutamyl-tRNAGlureductase binding protein Photosyn. Res., 137, 2018
4QAJ	Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa at 1.5 Angstrom resolution Descriptor: Peptidyl-tRNA hydrolase Authors: Singh, A, Kumar, A, Gautam, L, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Arora, A, Singh, T.P. Deposit date: 2014-05-05 Release date: 2014-05-28 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase Biochem.J., 463, 2014
1WKB	Crystal Structure of Leucyl-tRNA Synthetase from the Archaeon Pyrococcus horikoshii Reveals a Novel Editing Domain Orientation Descriptor: Leucyl-tRNA synthetase, SULFATE ION Authors: Fukunaga, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-05-30 Release date: 2005-02-08 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal Structure of Leucyl-tRNA Synthetase from the Archaeon Pyrococcus horikoshii Reveals a Novel Editing Domain Orientation J.Mol.Biol., 346, 2005
3LC0	Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidine complex) Descriptor: HISTIDINE, Histidyl-tRNA synthetase Authors: Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) Deposit date: 2010-01-08 Release date: 2010-01-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs. J.Mol.Biol., 397, 2010
1KRS	SOLUTION STRUCTURE OF THE ANTICODON BINDING DOMAIN OF ESCHERICHIA COLI LYSYL-TRNA SYNTHETASE AND STUDIES OF ITS INTERACTIONS WITH TRNA-LYS Descriptor: LYSYL-TRNA SYNTHETASE (PRODUCT OF LYSS GENE) Authors: Commans, S, Dardel, F. Deposit date: 1995-06-09 Release date: 1995-09-15 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of the anticodon-binding domain of Escherichia coli lysyl-tRNA synthetase and studies of its interaction with tRNA(Lys). J.Mol.Biol., 253, 1995
1KRT	SOLUTION STRUCTURE OF THE ANTICODON BINDING DOMAIN OF ESCHERICHIA COLI LYSYL-TRNA SYNTHETASE AND STUDIES OF ITS INTERACTIONS WITH TRNA-LYS Descriptor: LYSYL-TRNA SYNTHETASE (PRODUCT OF LYSS GENE) Authors: Commans, S, Dardel, F. Deposit date: 1995-06-09 Release date: 1995-09-15 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of the anticodon-binding domain of Escherichia coli lysyl-tRNA synthetase and studies of its interaction with tRNA(Lys). J.Mol.Biol., 253, 1995
1H4T	Prolyl-tRNA synthetase from Thermus thermophilus complexed with L-proline Descriptor: PROLINE, PROLYL-TRNA SYNTHETASE, ZINC ION Authors: Yaremchuk, A, Tukalo, M, Cusack, S. Deposit date: 2001-05-14 Release date: 2001-06-18 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase J.Mol.Biol., 309, 2001
3UH0	Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with threonyl sulfamoyl adenylate Descriptor: 5'-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE, SULFATE ION, Threonyl-tRNA synthetase, ... Authors: Peterson, K.M, Ling, J, Simonovic, I, Cho, C, Soll, D, Simonovic, M. Deposit date: 2011-11-03 Release date: 2012-02-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Yeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignment. Proc.Natl.Acad.Sci.USA, 109, 2012
3UGQ	Crystal structure of the apo form of the yeast mitochondrial threonyl-tRNA synthetase determined at 2.1 Angstrom resolution Descriptor: POTASSIUM ION, SULFATE ION, Threonyl-tRNA synthetase, ... Authors: Peterson, K.M, Ling, J, Simonovic, I, Cho, C, Soll, D, Simonovic, M. Deposit date: 2011-11-02 Release date: 2012-02-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Yeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignment. Proc.Natl.Acad.Sci.USA, 109, 2012
4Q2T	Crystal structure of Arginyl-tRNA synthetase complexed with L-arginine Descriptor: ARGININE, Arginine--tRNA ligase, cytoplasmic, ... Authors: Kim, H.S, Jo, C.H, Cha, S.Y, Han, A.R, Hwang, K.Y. Deposit date: 2014-04-09 Release date: 2014-07-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The crystal structure of arginyl-tRNA synthetase from Homo sapiens Febs Lett., 588, 2014

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