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5QAN
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BU of 5qan by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 19a
Descriptor: 3-[3-(methylsulfonylaminomethyl)phenyl]benzoic acid, Beta-lactamase, CHLORIDE ION
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QB2
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BU of 5qb2 by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 38
Descriptor: 1,2-ETHANEDIOL, 3-quinolin-6-yl-5-quinolin-7-yl-benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA4
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BU of 5qa4 by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 3a
Descriptor: 1,2-ETHANEDIOL, 3-(2-methylphenyl)benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAO
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BU of 5qao by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 19b
Descriptor: 1,2-ETHANEDIOL, 3-[4-(methylsulfonylaminomethyl)phenyl]benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QB0
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BU of 5qb0 by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 35
Descriptor: 1,2-ETHANEDIOL, 3-pyridin-2-ylbenzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA6
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BU of 5qa6 by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 4a
Descriptor: 1,2-ETHANEDIOL, 3-(2-hydroxyphenyl)benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAS
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BU of 5qas by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 23b
Descriptor: 1,2-ETHANEDIOL, 3-[4-(2-acetamidoethyl)phenyl]benzoic acid, Beta-lactamase
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAJ
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BU of 5qaj by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 13
Descriptor: 1,2-ETHANEDIOL, 3-(4-aminophenyl)benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAY
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BU of 5qay by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 32
Descriptor: 1,2-ETHANEDIOL, 3-(1-methylpyrrol-2-yl)benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAH
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BU of 5qah by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 9b
Descriptor: 1,2-ETHANEDIOL, 3-(3-methoxycarbonylphenyl)benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAZ
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BU of 5qaz by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 34
Descriptor: 1,2-ETHANEDIOL, 3-(1~{H}-indol-5-yl)benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA7
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BU of 5qa7 by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 4b
Descriptor: 1,2-ETHANEDIOL, 3-(3-hydroxyphenyl)benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAP
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BU of 5qap by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 21a
Descriptor: 1,2-ETHANEDIOL, 3-(3-acetamidophenyl)benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAF
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BU of 5qaf by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 8c
Descriptor: 1,2-ETHANEDIOL, 3-(4-fluorophenyl)benzoic acid, Beta-lactamase, ...
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAR
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BU of 5qar by Molmil
OXA-48 IN COMPLEX WITH COMPOUND 23a
Descriptor: 3-[3-(2-acetamidoethyl)phenyl]benzoic acid, Beta-lactamase, CHLORIDE ION
Authors:Lund, B.A, Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5TG4
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BU of 5tg4 by Molmil
OXA-24/40 in Complex with Boronic Acid BA16
Descriptor: BICARBONATE ION, Beta-lactamase, D-Glyceraldehyde, ...
Authors:Powers, R.A, Werner, J.P, Mitchell, J.M.
Deposit date:2016-09-27
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Exploring the potential of boronic acids as inhibitors of OXA-24/40 beta-lactamase.
Protein Sci., 26, 2017
5TG6
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BU of 5tg6 by Molmil
OXA-24/40 in Complex with Boronic Acid BA4
Descriptor: BICARBONATE ION, Beta-lactamase, SULFATE ION, ...
Authors:Powers, R.A, Werner, J.P, Mitchell, J.M.
Deposit date:2016-09-27
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Exploring the potential of boronic acids as inhibitors of OXA-24/40 beta-lactamase.
Protein Sci., 26, 2017
5TG5
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BU of 5tg5 by Molmil
OXA-24/40 in Complex with Boronic Acid BA8
Descriptor: BICARBONATE ION, Beta-lactamase, METHANETHIOL, ...
Authors:Powers, R.A, Werner, J.P, Mitchell, J.M.
Deposit date:2016-09-27
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Exploring the potential of boronic acids as inhibitors of OXA-24/40 beta-lactamase.
Protein Sci., 26, 2017
5TG7
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BU of 5tg7 by Molmil
OXA-24/40 in Complex with Boronic Acid BA3
Descriptor: (3-{[(furan-2-yl)methyl]carbamoyl}phenyl)boronic acid, BICARBONATE ION, Beta-lactamase, ...
Authors:Powers, R.A, Werner, J.P, Mitchell, J.M.
Deposit date:2016-09-27
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Exploring the potential of boronic acids as inhibitors of OXA-24/40 beta-lactamase.
Protein Sci., 26, 2017
3EQV
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BU of 3eqv by Molmil
Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing four mutations associated with penicillin resistance
Descriptor: GLYCEROL, Penicillin-binding protein 2, SULFATE ION
Authors:Powell, A.J, Deacon, A.M, Nicholas, R.A, Davies, C.
Deposit date:2008-10-01
Release date:2008-10-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance.
J.Biol.Chem., 284, 2009
6G9S
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BU of 6g9s by Molmil
Structural basis for the inhibition of E. coli PBP2
Descriptor: (3~{R},6~{S})-6-(aminomethyl)-4-(1,3-oxazol-5-yl)-3-(sulfooxyamino)-3,6-dihydro-2~{H}-pyridine-1-carboxylic acid, Peptidoglycan D,D-transpeptidase MrdA
Authors:Ruff, M, Levy, N.
Deposit date:2018-04-11
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
J.Med.Chem., 62, 2019
5TRO
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BU of 5tro by Molmil
1.8 Angstrom Resolution Crystal Structure of Dimerization and Transpeptidase domains (residues 39-608) of Penicillin-Binding Protein 1 from Staphylococcus aureus.
Descriptor: CHLORIDE ION, Penicillin-binding protein 1
Authors:Minasov, G, Shuvalova, L, Kiryukhina, O, Dubrovska, I, Grimshaw, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-10-26
Release date:2016-11-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:1.8 Angstrom Resolution Crystal Structure of Dimerization and Transpeptidase domains (residues 39-608) of Penicillin-Binding Protein 1 from Staphylococcus aureus.
To Be Published
7BN9
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BU of 7bn9 by Molmil
Crystal Structure of Bacillus subtilis Penicillin Binding Protein 3
Descriptor: Penicillin-binding protein 3
Authors:Rao, V.A, Lewis, R.J.
Deposit date:2021-01-21
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Cooperation between peptidoglycan transpeptidases and SEDS proteins in Bacillus subtilis cell division
To Be Published
5U47
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BU of 5u47 by Molmil
1.95 Angstrom Resolution Crystal Structure of Penicillin Binding Protein 2X from Streptococcus thermophilus
Descriptor: ACETATE ION, CHLORIDE ION, Penicillin binding protein 2X
Authors:Minasov, G, Shuvalova, L, Cardona-Correa, A, Dubrovska, I, Grimshaw, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-12-03
Release date:2016-12-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:1.95 Angstrom Resolution Crystal Structure of Penicillin Binding Protein 2X from Streptococcus thermophilus.
To Be Published
6BSR
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BU of 6bsr by Molmil
Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the benzylpenicillin bound form.
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Moon, T.M, D'Andrea, E.D, Peti, W, Page, R.
Deposit date:2017-12-04
Release date:2018-10-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance.
J. Biol. Chem., 293, 2018

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數據於2024-06-26公開中

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