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4YJZ	Human antibody H2526 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, scFv H2526 Authors: Schmidt, A.G, Harrison, S.C. Deposit date: 2015-03-03 Release date: 2015-05-27 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Viral receptor-binding site antibodies with diverse germline origins. Cell, 161, 2015
4WSS	The crystal structure of hemagglutinin form A/chicken/New York/14677-13/1998 in complex with LSTa Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... Authors: Yang, H, Carney, P.J, Chang, J.C, Villanueva, J.M, Stevens, J. Deposit date: 2014-10-28 Release date: 2015-02-25 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure and receptor binding preferences of recombinant hemagglutinins from avian and human h6 and h10 influenza a virus subtypes. J.Virol., 89, 2015
4WSV	The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 6'SLN Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ... Authors: Yang, H, Carney, P.J, Chang, J.C, Villanueva, J.M, Stevens, J. Deposit date: 2014-10-28 Release date: 2015-02-25 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure and receptor binding preferences of recombinant hemagglutinins from avian and human h6 and h10 influenza a virus subtypes. J.Virol., 89, 2015
6BKP	Crystal structure of the A/Michigan/15/2014 (H3N2) influenza virus hemagglutinin apo form Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... Authors: Wu, N.C, Wilson, I.A. Deposit date: 2017-11-09 Release date: 2018-02-28 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.05 Å) Cite: A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018
6E3H	Crystal structure of S9-3-37 bound to H5 influenza hemagglutinin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ... Authors: Wu, N.C, Wilson, I.A. Deposit date: 2018-07-14 Release date: 2018-09-26 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The D3-9 gene segment encodes for recurring and adaptable binding motifs in broadly neutralizing antibodies to influenza virus Cell Host Microbe, 2018
4YK4	Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 641 I-9 VHCH antibody, 641 I-9 VLCL antibody, ... Authors: Schmidt, A.G, Harrison, S.C. Deposit date: 2015-03-03 Release date: 2015-05-27 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Viral receptor-binding site antibodies with diverse germline origins. Cell, 161, 2015
6D8W	Crystal structure of InvbI.18715.a.KN11: Influenza hemagglutinin from strain A/Jiangsu/ALSI/2011 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FORMIC ACID, Hemagglutinin, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-04-27 Release date: 2018-05-09 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site. Sci Rep, 13, 2023
4YY1	The structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) in complex with human receptor analog 6'SLNLN Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HA1, ... Authors: Wang, F, Qi, J, Bi, Y, Zhang, W, Wang, M, Wang, M, Liu, J, Yan, J, Shi, Y, Gao, G.F. Deposit date: 2015-03-23 Release date: 2016-03-23 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) To Be Published
6E7G	Crystal structure of H5 hemagglutinin mutant Y161A from A/Viet Nam/1203/2004 H5N1 influenza virus Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ... Authors: Tzarum, N, Wilson, I.A. Deposit date: 2018-07-26 Release date: 2019-06-19 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3.094 Å) Cite: N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses. Cell Rep, 27, 2019
6CF5	Crystal structure of the A/Viet Nam/1203/2004(H5N1) influenza virus hemagglutinin in complex with small molecule N-Cyclohexyltaurine Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Wilson, I.A, Kadam, R.U. Deposit date: 2018-02-13 Release date: 2018-04-04 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.04 Å) Cite: A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CFG	Crystal structure of the A/Vietnam/1203/2004 (H5N1) influenza virus hemagglutinin in complex with small molecule JNJ4796 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... Authors: Kadam, R.U, Wilson, I.A. Deposit date: 2018-02-14 Release date: 2019-02-13 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.32 Å) Cite: A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science, 363, 2019
6LKS	Effects of zinc ion on oligomerization and pH stability of influenza virus hemagglutinin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Seok, J, Kim, K. Deposit date: 2019-12-20 Release date: 2020-10-21 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3.24 Å) Cite: Divalent cation-induced conformational changes of influenza virus hemagglutinin. Sci Rep, 10, 2020
9BDF	Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85666 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-85666 Fab heavy chain, ... Authors: Ferreira Ramos, A.S, Bajic, G. Deposit date: 2024-04-11 Release date: 2024-11-13 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies. Sci Adv, 11, 2025
9BU8	Vaccine elicited Fab c115.131 with influenza H10 JD13 HA trimer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab c115.131 heavy chain, Fab c115.131 light chain, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2024-05-16 Release date: 2024-11-27 Last modified: 2025-01-22 Method: ELECTRON MICROSCOPY (3.96 Å) Cite: Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem-specific human B cells. Sci Transl Med, 17, 2025
9BU6	Vaccine elicited Fab C968.180 with influenza H10 JD13 HA trimer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab C968.180 heavy chain, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2024-05-16 Release date: 2024-11-27 Last modified: 2025-01-22 Method: ELECTRON MICROSCOPY (3.65 Å) Cite: Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem-specific human B cells. Sci Transl Med, 17, 2025
9B2M	Hemagglutinin H1 New Caledonia 1999 in complex with monoclonal antibody Fab 43_S0008 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain monoclonal antibody Fab 3_S0008, Hemagglutinin HA1 chain, ... Authors: Torrents de la Pena, A, de Paiva Froes Rocha, R, Ward, A.B, Ataca, S, Kanekiyo, M. Deposit date: 2024-03-15 Release date: 2024-12-11 Method: ELECTRON MICROSCOPY (3.09 Å) Cite: Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem. Cell Rep, 43, 2024
9B7G	Cryo-EM structure of antibody TJ5-13 bound to H3 COBRA NG2 hemagglutinin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Dzimianski, J.V, Cruz, J.M, Serrao, V.H.B, DuBois, R.M. Deposit date: 2024-03-27 Release date: 2025-05-07 Method: ELECTRON MICROSCOPY (2.61 Å) Cite: Assessing the structural boundaries of broadly reactive antibody interactions with diverse H3 influenza hemagglutinin proteins To Be Published
9B7H	Crystal structure of the H3 hemagglutinin COBRA TJ2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... Authors: Dzimianski, J.V, DuBois, R.M. Deposit date: 2024-03-27 Release date: 2025-05-07 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Assessing the structural boundaries of broadly reactive antibody interactions with diverse H3 influenza hemagglutinin proteins To Be Published
9B7I	Crystal structure of the H3 hemagglutinin COBRA J4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ... Authors: Dzimianski, J.V, DuBois, R.M. Deposit date: 2024-03-27 Release date: 2025-05-07 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Assessing the structural boundaries of broadly reactive antibody interactions with diverse H3 influenza hemagglutinin proteins To Be Published
9BT5	The crystal structure of the HA1 domain of hemagglutinin from A/Shanghai/02/2013 (H7N9) bound to H7-235 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Monoclonal antibody H7-235 heavy chain, ... Authors: Buchman, C.D, Dong, J, Crowe, J.E. Deposit date: 2024-05-14 Release date: 2025-06-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance. JCI Insight, 2025
9C0V	Crystal structure of chimeric hemagglutinin cH5/1 in complex with broad protective antibody 3E1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 3E1 Fab heavy chain, Antibody 3E1 Fab light chain, ... Authors: Nguyen, T.K.Y, Wilson, I.A. Deposit date: 2024-05-27 Release date: 2025-01-29 Last modified: 2025-05-28 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural characterization of influenza group 1 chimeric hemagglutinins as broad vaccine immunogens. Proc.Natl.Acad.Sci.USA, 122, 2025
6ML8	Crystal structure of hemagglutinin from H1N1 Influenza A virus A/Denver/57 bound to the C05 antibody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C05 antibody Fab heavy chain, C05 antibody Fab light chain, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-09-27 Release date: 2018-10-17 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site. Sci Rep, 13, 2023
9C0X	Crystal structure of chimeric hemagglutinin cH11/1 in complex with broad protective antibody 31.b.09 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 31.b.09 Fab heavy chain, ... Authors: Nguyen, T.K.Y, Zhu, X, Wilson, I.A. Deposit date: 2024-05-28 Release date: 2025-05-07 Last modified: 2025-05-28 Method: X-RAY DIFFRACTION (4.35 Å) Cite: Structural characterization of influenza group 1 chimeric hemagglutinins as broad vaccine immunogens. Proc.Natl.Acad.Sci.USA, 122, 2025
6MYA	Crystal structure of InvbP.18715.a.KN11: Influenza hemagglutinin from strain A/Almaty/32/1998 Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-11-01 Release date: 2018-11-14 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site. Sci Rep, 13, 2023
6N08	Crystal structure of hemagglutinin from influenza virus A/Netherlands/209/1980 (H3N2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... Authors: Dai, Y.N, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2018-11-06 Release date: 2019-05-15 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.916 Å) Cite: Crystal structure of hemagglutinin from influenza virus A/Netherlands/209/1980 (H3N2) to be published

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