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7FGW	Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with pyrimethamine, NADPH and dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, BENZAMIDINE, ... Authors: Vanichtanankul, J, Yoomuang, A, Taweechai, S, Saeyang, T, Yuvaniyama, Y, Tarnchompoo, B, Yuthavong, Y, Kamchonwongpaisan, S. Deposit date: 2021-07-28 Release date: 2022-06-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17, 2022
7FGY	Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P40, NADPH and dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(3-chlorophenyl)-6-[2-(3-phenoxypropoxy)ethyl]pyrimidine-2,4-diamine, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Vanichtanankul, J, Yoomuang, A, Taweechai, S, Saeyang, T, Yuvaniyama, J, Tarnchompoo, B, Yuthavong, Y, Kamchonwongpaisan, S. Deposit date: 2021-07-28 Release date: 2022-06-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17, 2022
7TA9	Crystal Structure of thymidylate synthase from Acinetobacter baumannii Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-20 Release date: 2022-01-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure of thymidylate synthase from Acinetobacter baumannii to be published
7XYJ	Structure of WSSV thymidylate synthase in complex with dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PENTAETHYLENE GLYCOL, ... Authors: Ma, Q, Liu, C, Zang, K. Deposit date: 2022-06-01 Release date: 2023-06-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.275 Å) Cite: Structure of WSSV thymidylate synthase in complex with dUMP To Be Published
7XYK	Structure of WSSV thymidylate synthase in complex with dUMP and raltitrexed Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, SULFATE ION, TOMUDEX, ... Authors: Ma, Q, Liu, C, Zang, K. Deposit date: 2022-06-01 Release date: 2023-06-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.433 Å) Cite: Structure of WSSV thymidylate synthase in complex with dUMP and raltitrexed To Be Published
8DAE	Arabidopsis thaliana bifunctional dihydrofolate reductase-thymidylate synthase Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase 1 Authors: Bond, C.S, Haywood, J. Deposit date: 2022-06-13 Release date: 2023-06-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Arabidopsis thaliana bifunctional dihydrofolate reductase-thymidylate synthase To Be Published
8JFB	V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 4 (B21588), NADPH and dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-[4-[[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]methyl]phenyl]benzoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Vanichtanankul, J, Saeyang, T, Vitsupakorn, D, Saepua, S, Thongpanchang, C, Yuthavong, Y, Kamchonwongpaisan, S, Hoarau, M. Deposit date: 2023-05-17 Release date: 2023-08-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Discovery of rigid biphenyl Plasmodium falciparum DHFR inhibitors using a fragment linking strategy. Rsc Med Chem, 14, 2023
8JFD	V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 8 (B21594), NADPH and dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-[3-[[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]methyl]phenyl]benzoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Vanichtanankul, J, Saeyang, T, Vitsupakorn, D, Saepua, S, Thongpanchang, C, Yuthavong, Y, Kamchonwongpaisan, S, Hoarau, M. Deposit date: 2023-05-17 Release date: 2023-08-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of rigid biphenyl Plasmodium falciparum DHFR inhibitors using a fragment linking strategy. Rsc Med Chem, 14, 2023
8JFC	V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 6 (B21591), NADPH and dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 4-[3-[[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]methyl]phenyl]benzoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Vanichtanankul, J, Saeyang, T, Vitsupakorn, D, Saepua, S, Thongpanchang, C, Yuthavong, Y, Kamchonwongpaisan, S, Hoarau, M. Deposit date: 2023-05-17 Release date: 2023-08-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of rigid biphenyl Plasmodium falciparum DHFR inhibitors using a fragment linking strategy. Rsc Med Chem, 14, 2023

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