8G70
| SARS-CoV-2 spike/nanobody mixture complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-3, ... | Authors: | Ye, G, Bu, F, Liu, B, Li, F. | Deposit date: | 2023-02-16 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | SARS-CoV-2 spike/nanobody mixture complex To Be Published
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8G40
| N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI19 Fab molecules | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Dang, H.V, Snell, G. | Deposit date: | 2023-02-08 | Release date: | 2023-05-31 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | A pan-influenza antibody inhibiting neuraminidase via receptor mimicry. Nature, 618, 2023
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8G3Z
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8G3V
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8G3R
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8G3Q
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8G3P
| N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI9 Fab molecules | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Dang, H.V, Snell, G. | Deposit date: | 2023-02-08 | Release date: | 2023-05-31 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | A pan-influenza antibody inhibiting neuraminidase via receptor mimicry. Nature, 618, 2023
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8G3O
| N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI9 Fab molecules | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Dang, H.V, Snell, G. | Deposit date: | 2023-02-08 | Release date: | 2023-05-31 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A pan-influenza antibody inhibiting neuraminidase via receptor mimicry. Nature, 618, 2023
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8G3N
| N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI9 Fab molecules | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Dang, H, Snell, G. | Deposit date: | 2023-02-08 | Release date: | 2023-05-31 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | A pan-influenza antibody inhibiting neuraminidase via receptor mimicry. Nature, 618, 2023
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8G3M
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8G30
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8G2I
| Crystal Structure of PRMT4 with Compound YD1290 | Descriptor: | 5'-([2-(benzylcarbamamido)ethyl]{3-[N'-(3-bromophenyl)carbamimidamido]propyl}amino)-5'-deoxyadenosine, Histone-arginine methyltransferase CARM1, UNKNOWN ATOM OR ION | Authors: | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2023-02-03 | Release date: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharm Sin B, 13, 2023
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8G2H
| Crystal Structure of PRMT4 with Compound YD1113 | Descriptor: | 5'-S-[2-(benzylcarbamamido)ethyl]-5'-thioadenosine, GLYCEROL, Histone-arginine methyltransferase CARM1, ... | Authors: | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2023-02-03 | Release date: | 2023-12-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharm Sin B, 13, 2023
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8G2G
| Crystal structure of PRMT3 with compound YD1113 | Descriptor: | 5'-S-[2-(benzylcarbamamido)ethyl]-5'-thioadenosine, Protein arginine N-methyltransferase 3, SULFATE ION | Authors: | Song, X, Dong, A, Arrowsmith, C.H, Edwards, A.M, Deng, Y, Huang, R, Min, J. | Deposit date: | 2023-02-03 | Release date: | 2023-04-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharm Sin B, 13, 2023
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8G2F
| Crystal Structure of PRMT3 with Compound II710 | Descriptor: | 5'-S-[3-(N'-benzylcarbamimidamido)propyl]-5'-thioadenosine, Protein arginine N-methyltransferase 3 | Authors: | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2023-02-03 | Release date: | 2023-05-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharm Sin B, 13, 2023
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8G0L
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8FYX
| Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | Descriptor: | Buspirone, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | Deposit date: | 2023-01-26 | Release date: | 2024-05-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 2024
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8FYT
| LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | Deposit date: | 2023-01-26 | Release date: | 2024-05-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 2024
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8FYL
| Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | Descriptor: | 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | Deposit date: | 2023-01-26 | Release date: | 2024-05-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 2024
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8FYE
| 4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | Descriptor: | 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | Deposit date: | 2023-01-26 | Release date: | 2024-05-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 2024
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8FY8
| 5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | Descriptor: | 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethan-1-amine, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | Deposit date: | 2023-01-25 | Release date: | 2024-05-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 2024
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8FWX
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8FQ7
| Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | Descriptor: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | Authors: | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | Deposit date: | 2023-01-05 | Release date: | 2023-10-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
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8FKS
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8FKR
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