7BA3
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![BU of 7ba3 by Molmil](/molmil-images/mine/7ba3) | Cys-42-tethered stabilizer 6 of 14-3-3(sigma)/ERa PPI | Descriptor: | 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... | Authors: | Sijbesma, E, Ottmann, C. | Deposit date: | 2020-12-15 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
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7B9T
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![BU of 7b9t by Molmil](/molmil-images/mine/7b9t) | Cys-45-tethered stabilizer 5 of 14-3-3(sigma)/ERa PPI | Descriptor: | 14-3-3 protein sigma, 2-(4-chlorophenyl)sulfanyl-~{N}-(3-sulfanylpropyl)ethanamide, Estrogen receptor, ... | Authors: | Sijbesma, E, Ottmann, C. | Deposit date: | 2020-12-14 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
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7B9M
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![BU of 7b9m by Molmil](/molmil-images/mine/7b9m) | Cys-45-tethered stabilizer 3 of 14-3-3(sigma)/ERa PPI | Descriptor: | 14-3-3 protein sigma, 2-(2-cyanophenyl)sulfanyl-~{N}-(2-sulfanylethyl)benzamide, Estrogen receptor, ... | Authors: | Sijbesma, E, Ottmann, C. | Deposit date: | 2020-12-14 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
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7B9R
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![BU of 7b9r by Molmil](/molmil-images/mine/7b9r) | Cys-45-tethered stabilizer 4 of 14-3-3(sigma)/ERa PPI | Descriptor: | 14-3-3 protein sigma, 2-(2-cyanophenyl)sulfanyl-~{N}-(3-sulfanylpropyl)benzamide, Estrogen receptor, ... | Authors: | Sijbesma, E, Ottmann, C. | Deposit date: | 2020-12-14 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
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7B15
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![BU of 7b15 by Molmil](/molmil-images/mine/7b15) | |
7B13
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![BU of 7b13 by Molmil](/molmil-images/mine/7b13) | |
7AZ2
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![BU of 7az2 by Molmil](/molmil-images/mine/7az2) | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014 | Descriptor: | 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... | Authors: | Wolter, M, Dijck, L.v, Ottmann, C. | Deposit date: | 2020-11-14 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.081 Å) | Cite: | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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7AZ1
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![BU of 7az1 by Molmil](/molmil-images/mine/7az1) | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013 | Descriptor: | 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... | Authors: | Wolter, M, Dijck, L.v, Ottmann, C. | Deposit date: | 2020-11-14 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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7AYF
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![BU of 7ayf by Molmil](/molmil-images/mine/7ayf) | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-110 | Descriptor: | 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, CALCIUM ION, ... | Authors: | Wolter, M, Dijck, L.v, Ottmann, C. | Deposit date: | 2020-11-12 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.752 Å) | Cite: | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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7AXN
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![BU of 7axn by Molmil](/molmil-images/mine/7axn) | 14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026 | Descriptor: | 14-3-3 protein sigma, 3-chloranyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ... | Authors: | Wolter, M, Dijck, L.v, Ottmann, C. | Deposit date: | 2020-11-10 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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7AOG
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![BU of 7aog by Molmil](/molmil-images/mine/7aog) | 14-3-3 sigma in complex with Pin1 binding site pS72 | Descriptor: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | Authors: | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | Deposit date: | 2020-10-14 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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7D9V
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![BU of 7d9v by Molmil](/molmil-images/mine/7d9v) | |
7D8P
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![BU of 7d8p by Molmil](/molmil-images/mine/7d8p) | |
7D8H
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![BU of 7d8h by Molmil](/molmil-images/mine/7d8h) | |
7AEW
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![BU of 7aew by Molmil](/molmil-images/mine/7aew) | |
7A6Y
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![BU of 7a6y by Molmil](/molmil-images/mine/7a6y) | |
7A6R
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![BU of 7a6r by Molmil](/molmil-images/mine/7a6r) | |
6ZVC
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![BU of 6zvc by Molmil](/molmil-images/mine/6zvc) | |
6ZVB
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![BU of 6zvb by Molmil](/molmil-images/mine/6zvb) | |
6ZVE
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![BU of 6zve by Molmil](/molmil-images/mine/6zve) | |
6ZVD
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![BU of 6zvd by Molmil](/molmil-images/mine/6zvd) | |
6ZFD
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![BU of 6zfd by Molmil](/molmil-images/mine/6zfd) | 14-3-3 zeta bound to the phosphorylated 18E6 C-terminus | Descriptor: | 14-3-3 protein zeta/delta,Protein E6, GLYCEROL | Authors: | Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. | Deposit date: | 2020-06-17 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
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6ZFG
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![BU of 6zfg by Molmil](/molmil-images/mine/6zfg) | 14-3-3 zeta chimera with 18E6 and fusicoccin | Descriptor: | 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL | Authors: | Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. | Deposit date: | 2020-06-17 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
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6ZCJ
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![BU of 6zcj by Molmil](/molmil-images/mine/6zcj) | 14-3-3sigma in complex with SLP76pS376 phosphopeptide crystal structure | Descriptor: | 14-3-3 protein sigma, MAGNESIUM ION, SLP76pS376 | Authors: | Soini, L, Leysen, S, Davis, J, Ottmann, C. | Deposit date: | 2020-06-11 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. Febs Lett., 595, 2021
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6ZC9
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![BU of 6zc9 by Molmil](/molmil-images/mine/6zc9) | Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser448 | Descriptor: | 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like | Authors: | Pohl, P, Kalabova, D, Obsil, T, Obsilova, V. | Deposit date: | 2020-06-10 | Release date: | 2021-07-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.89895988 Å) | Cite: | 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
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