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7YBB	Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with D-4-hydroxy-2-oxoglutarate and factor X-derived peptide (39mer-4Ser) Descriptor: (2~{R})-2-oxidanyl-4-oxidanylidene-pentanedioic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... Authors: Nakashima, Y, Brewitz, L, Schofield, C.J. Deposit date: 2022-06-29 Release date: 2023-07-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with D-4-hydroxy-2-oxoglutarate and factor X-derived peptide (39mer-4Ser) To Be Published
8D1B	CryoEM structure of human orphan GPCR GPR179 in complex with extracellular matrix protein pikachurin Descriptor: Pikachurin, Probable G-protein coupled receptor 179 Authors: Patil, D.N, Martemyanov, K.A. Deposit date: 2022-05-27 Release date: 2023-07-26 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.57 Å) Cite: Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179. Sci.Signal., 16, 2023
8EOK	Structure of the C3bB proconvertase in complex with lufaxin and factor Xa Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ... Authors: Andersen, J.F, Lei, H. Deposit date: 2022-10-03 Release date: 2023-08-30 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
8ET0	Crystal Complex of murine Cyclooxygenase-2 with alpaca nanobody F9 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IBUPROFEN, ... Authors: Xu, S, Banerjee, S, Uddin, M.J, Goodman, M.C, Marnett, L.J. Deposit date: 2022-10-15 Release date: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal complex of murine cycloxygenase-2 with alpaca nanobody F9 To Be Published
8CN9	Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII Descriptor: CALCIUM ION, CESIUM ION, Coagulation factor VII, ... Authors: Schluckebier, G, Johansson, E. Deposit date: 2023-02-22 Release date: 2023-12-27 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (3.4 Å) Cite: A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders. Nat Cardiovasc Res, 3, 2024
8U4L	Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... Authors: Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. Deposit date: 2023-09-10 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (3.31 Å) Cite: Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain To Be Published
8U4I	Structure of the HER4/NRG1b Homodimer Extracellular Domain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... Authors: Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. Deposit date: 2023-09-10 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain To Be Published
8OS5	Crystal structure of the Factor XII heavy chain reveals an interlocking dimer with a FnII to kringle domain interaction Descriptor: Coagulation factor XII-Mie Authors: Li, C, Saleem, M, Kaira, B.G, Brown, A, Wilson, C, Philippou, H, Emsley, J. Deposit date: 2023-04-18 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery. Blood, 136, 2020
8EPH	Crystal structure of human coagulation factor IXa (S195A), apo-form, DES-GLA Descriptor: CALCIUM ION, Coagulation factor IXa heavy chain, Coagulation factor IXa light chain, ... Authors: Kolyadko, V.N, Krishnaswamy, S. Deposit date: 2022-10-05 Release date: 2024-07-03 Last modified: 2024-07-24 Method: X-RAY DIFFRACTION (1.88 Å) Cite: An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa. Proc.Natl.Acad.Sci.USA, 121, 2024
9CTH	Preliminary map of the Prothrombin-prothrombinase complex on nano discs Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated Factor V (FVa) heavy chain, Activated Factor V (FVa) light chain, ... Authors: Stojanovski, B.M, Mohammed, B.M, Di Cera, E. Deposit date: 2024-07-25 Release date: 2024-08-07 Last modified: 2024-08-14 Method: ELECTRON MICROSCOPY (6.47 Å) Cite: The Prothrombin-Prothrombinase Interaction. Subcell Biochem, 104, 2024

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