7EUN
 
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7EUQ
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7EUL
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7EUK
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7ET7
 | | Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with tricyclic small molecule inhibitor JBSNF-000028 | | Descriptor: | 10-methyl-1,10-diazatricyclo[6.3.1.0^{4,12}]dodeca-4,6,8(12)-trien-11-imine, Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Swaminathan, S, Gosu, R, Birudukota, S, Kandan, S, Vaithilingam, K. | | Deposit date: | 2021-05-12 | | Release date: | 2022-05-18 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Sci Rep, 12, 2022
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7F5G
 | | The crystal structure of RBD-Nanobody complex, DL4 (SA4) | | Descriptor: | ACETATE ION, GLYCEROL, Nanobody DL4, ... | | Authors: | Li, T, Lai, Y, Zhou, Y, Tan, J, Li, D. | | Deposit date: | 2021-06-22 | | Release date: | 2022-05-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2.
Int.J.Biol.Macromol., 209, 2022
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7EXO
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7FHP
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7FHM
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7EWS
 | | Crystal structure of arginine kinase (AK3) from the ciliate Paramecium tetraurelia | | Descriptor: | arginine kinase | | Authors: | Otsuka, Y, Yokota, J, Yano, D, Uda, K, Suzuki, T, Sugiyama, S. | | Deposit date: | 2021-05-26 | | Release date: | 2022-06-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of arginine kinase (AK3) from the ciliate Paramecium tetraurelia
To Be Published
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7EZD
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7F01
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7FIC
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7FJH
 | | LecA from Pseudomonas aeruginosa in complex with 4-Phenylbutyryl hydroxamic acid (CAS: 32153-46-1) | | Descriptor: | CALCIUM ION, N-oxidanyl-4-phenyl-butanamide, PA-I galactophilic lectin | | Authors: | Shanina, S, Kuhaudomlarp, S, Siebs, E, Fuchsberger, F, Denis, M, da Silva Figueiredo Celstino Gomes, P, Clausen, M.H, Seeberger, P.H, Rognan, D, Titz, A, Imberty, A, Rademacher, C. | | Deposit date: | 2021-08-04 | | Release date: | 2022-06-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Targeting undruggable carbohydrate recognition sites through focused fragment library design.
Commun Chem, 5, 2022
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7F1Y
 | | L-lactate oxidase without substrate | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Morimoto, Y, Inaka, K. | | Deposit date: | 2021-06-10 | | Release date: | 2022-06-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Dynamic interactions in the l-lactate oxidase active site facilitate substrate binding at pH4.5.
Biochem.Biophys.Res.Commun., 568, 2021
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7FHE
 | | Structure of prenyltransferase mutant Q295F from Streptomyces sp. (strain CL190) | | Descriptor: | Prenyltransferase | | Authors: | Xue, B, Lim, K.J.H, Hartono, Y.D, Go, M.D.K, Fan, H, Yew, W.S. | | Deposit date: | 2021-07-29 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Guided Engineering of Prenyltransferase NphB for High-Yield and Regioselective Cannabinoid Production.
Acs Catalysis, 12, 2022
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7FHC
 | | Structure of prenyltransferase mutant V49W from Streptomyces sp. (strain CL190) | | Descriptor: | Prenyltransferase | | Authors: | Xue, B, Lim, K.J.H, Hartono, Y.D, Go, M.D.K, Fan, H, Yew, W.S. | | Deposit date: | 2021-07-29 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Structure-Guided Engineering of Prenyltransferase NphB for High-Yield and Regioselective Cannabinoid Production.
Acs Catalysis, 12, 2022
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7FHD
 | | Structure of prenyltransferase mutant Y288P from Streptomyces sp. (strain CL190) | | Descriptor: | Prenyltransferase | | Authors: | Xue, B, Lim, K.J.H, Hartono, Y.D, Go, M.D.K, Fan, H, Yew, W.S. | | Deposit date: | 2021-07-29 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure-Guided Engineering of Prenyltransferase NphB for High-Yield and Regioselective Cannabinoid Production.
Acs Catalysis, 12, 2022
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7F74
 | | Rv3094c in complex with FMN. | | Descriptor: | FLAVIN MONONUCLEOTIDE, Rv3094c | | Authors: | Wang, Z.X, Ouyang, S.Y. | | Deposit date: | 2021-06-27 | | Release date: | 2022-06-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene.
Commun Biol, 6, 2023
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7F5D
 | | Crystal structure of BPTF-BRD with ligand DC-BPi-03 bound | | Descriptor: | 6-(1H-indol-5-yl)-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF | | Authors: | Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C. | | Deposit date: | 2021-06-21 | | Release date: | 2022-06-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.57150865 Å) | | Cite: | Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins
To Be Published
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7FHF
 | | Structure of prenyltransferase mutant V49W/Y288F/Q295F from Streptomyces sp. (strain CL190) | | Descriptor: | Prenyltransferase | | Authors: | Xue, B, Lim, K.J.H, Hartono, Y.D, Go, M.D.K, Fan, H, Yew, W.S. | | Deposit date: | 2021-07-29 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Guided Engineering of Prenyltransferase NphB for High-Yield and Regioselective Cannabinoid Production.
Acs Catalysis, 12, 2022
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7F5E
 | | Crystal structure of BPTF-BRD with ligand DC-BPi-11 bound | | Descriptor: | N,N-dimethyl-3-[5-(2-methylsulfonyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)indol-1-yl]propan-1-amine, Nucleosome-remodeling factor subunit BPTF | | Authors: | Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C. | | Deposit date: | 2021-06-21 | | Release date: | 2022-06-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.20017123 Å) | | Cite: | Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins
To Be Published
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7F5C
 | | Crystal structure of BPTF-BRD with ligand DC-BPi-07 bound | | Descriptor: | 6-[1-[3-(dimethylamino)propyl]indol-5-yl]-2-methylsulfonyl-N-propyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF | | Authors: | Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C. | | Deposit date: | 2021-06-21 | | Release date: | 2022-06-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.65004492 Å) | | Cite: | Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins
To Be Published
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7F7D
 | | Crystal structure of Non-specific class-C acid phosphatase from Sphingobium sp. RSMS bound to Adenosine at pH 5.5 | | Descriptor: | ADENOSINE, Acid phosphatase, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Gaur, N.K, Kumar, A, Sunder, S, Mukhopadhyaya, R, Makde, R.D. | | Deposit date: | 2021-06-28 | | Release date: | 2022-07-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Non-Specific Class-c acidphosphatase from Sphingobium sp. RSMS
To Be Published
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7F87
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