7F5E

Crystal structure of BPTF-BRD with ligand DC-BPi-11 bound

Summary for 7F5E

• Entry DOI: 10.2210/pdb7f5e/pdb
• Descriptor: Nucleosome-remodeling factor subunit BPTF, N,N-dimethyl-3-[5-(2-methylsulfonyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)indol-1-yl]propan-1-amine (3 entities in total)
• Functional Keywords: bptf bromodomain, lysine acetylation, small-molecule inhibitor, biosynthetic protein, antitumor protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 13783.78

Authors

Lu, T.,Lu, H.B.,Wang, J.,Lin, H.,Lu, W.,Luo, C. (deposition date: 2021-06-21, release date: 2022-06-29, Last modification date: 2023-11-29)

• Primary citation: Lu, T.,Lu, H.B.,Wang, J.,Han, J.,Xiao, S.,Jiang, H.,Chen, Y.,Yang, F.,Li, Q.,Jiang, H.L.,Chen, K.X.,Lu, W.C.,Lin, H.,Luo, C.; Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.20017124371 Å)