PDB: 340 resultsInfo pagesStatus searchChemie searchBIRD

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5G0X	Pseudomonas aeruginosa HDAH bound to acetate. Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, HDAH, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-03-23 Release date: 2016-11-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa. Biochemistry, 55, 2016
5G11	Pseudomonas aeruginosa HDAH bound to PFSAHA. Descriptor: 2,2,3,3,4,4,5,5,6,6,7,7-dodecakis(fluoranyl)-~{N}-oxidanyl-~{N}'-phenyl-octanediamide, HDAH, POTASSIUM ION, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-03-23 Release date: 2016-11-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa. Biochemistry, 55, 2016
5G10	Pseudomonas aeruginosa HDAH bound to 9,9,9 trifluoro-8,8-dihydroy-N-phenylnonanamide Descriptor: 9,9,9-tris(fluoranyl)-8,8-bis(oxidanyl)-~{N}-phenyl-nonanamide, HDAH, POTASSIUM ION, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-03-23 Release date: 2016-11-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa. Biochemistry, 55, 2016
5LI3	Crystal structure of HDAC-like protein from P. aeruginosa in complex with a photo-switchable inhibitor. Descriptor: (2E)-N-hydroxy-3-{4-[(E)-(1,3,5-trimethyl-1H-pyrazol-4-yl)diazenyl]phenyl}prop-2-enamide, Acetoin utilization protein, POTASSIUM ION, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-07-14 Release date: 2016-11-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors. ACS Infect Dis, 3, 2017
5G3W	Structure of HDAC like protein from Bordetella Alcaligenes in complex with the photoswitchable inhibitor CEW65 Descriptor: (2E)-N-hydroxy-3-{4-[(E)-phenyldiazenyl]phenyl}prop-2-enamide, DI(HYDROXYETHYL)ETHER, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-05-02 Release date: 2016-11-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors. ACS Infect Dis, 3, 2017
5G1C	Structure of HDAC like protein from Bordetella Alcaligenes bound the photoswitchable pyrazole Inhibitor CEW395 Descriptor: (2E)-N-hydroxy-3-{4-[(E)-(1,3,5-trimethyl-1H-pyrazol-4-yl)diazenyl]phenyl}prop-2-enamide, DI(HYDROXYETHYL)ETHER, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ... Authors: Kraemer, A, Meyer-Almes, F.J, Yildiz, O. Deposit date: 2016-03-24 Release date: 2016-11-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors. ACS Infect Dis, 3, 2017
5FCW	HDAC8 Complexed with a Hydroxamic Acid Descriptor: 4-naphthalen-1-yl-~{N}-oxidanyl-benzamide, GLYCEROL, HEXAETHYLENE GLYCOL, ... Authors: Cole, K.E, Perry, K. Deposit date: 2015-12-15 Release date: 2016-10-26 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.979 Å) Cite: Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket. J.Struct.Biol., 195, 2016
5IWG	HDAC2 WITH LIGAND BRD4884 Descriptor: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Steinbacher, S. Deposit date: 2016-03-22 Release date: 2016-08-31 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
5IX0	HDAC2 WITH LIGAND BRD7232 Descriptor: (3-exo)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-8-oxabicyclo[3.2.1]octane-3-carboxamide, 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ... Authors: Steinbacher, S. Deposit date: 2016-03-23 Release date: 2016-08-31 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
5EFN	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (H574A) in complex with histone H4 Lys6 tripeptide substrate Descriptor: 1,2-ETHANEDIOL, 7-AMINO-4-METHYL-CHROMEN-2-ONE, Hdac6 protein, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-24 Release date: 2016-07-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.804 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EF7	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with HPOB Descriptor: 4-[2-[2-hydroxyethyl(phenyl)amino]-2-oxidanylidene-ethyl]-~{N}-oxidanyl-benzamide, Hdac6 protein, POTASSIUM ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EEI	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with SAHA Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-22 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFG	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with acetate Descriptor: ACETATE ION, Hdac6 protein, POTASSIUM ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EEK	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with trichostatin A Descriptor: 1,2-ETHANEDIOL, AMMONIUM ION, CHLORIDE ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EEN	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with belinostat Descriptor: Belinostat, CHLORIDE ION, Hdac6 protein, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.861 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFK	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (Y745F mutant) in complex with alpha tubulin K40 tripeptide substrate Descriptor: 1,2-ETHANEDIOL, 7-AMINO-4-METHYL-CHROMEN-2-ONE, DI(HYDROXYETHYL)ETHER, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EEF	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 in complex with trichostatin A Descriptor: 1,2-ETHANEDIOL, AMMONIUM ION, HDAC6, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-22 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.151 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFH	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue Descriptor: 1,2-ETHANEDIOL, 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, BROMIDE ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.162 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EDU	Crystal structure of human histone deacetylase 6 catalytic domain 2 in complex with trichostatin A Descriptor: Maltose-binding periplasmic protein, Histone deacetylase 6 chimera, POTASSIUM ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-22 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EF8	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Hdac6 protein, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFJ	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with HC toxin Descriptor: 1,2-ETHANEDIOL, GLYCEROL, HC toxin, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EEM	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 Descriptor: FORMIC ACID, Hdac6 protein, POTASSIUM ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5EFB	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with oxamflatin Descriptor: Hdac6 protein, Oxamflatin, POTASSIUM ION, ... Authors: Hai, Y, Christianson, D.W. Deposit date: 2015-10-23 Release date: 2016-07-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.543 Å) Cite: Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
5G0I	Crystal structure of Danio rerio HDAC6 CD1 and CD2 (linker cleaved) in complex with Nexturastat A Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, HDAC6, ... Authors: Miyake, Y, Keusch, J.J, Wang, L, Saito, M, Hess, D, Wang, X, Melancon, B.J, Helquist, P, Gut, H, Matthias, P. Deposit date: 2016-03-18 Release date: 2016-07-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12, 2016
5G0J	Crystal structure of Danio rerio HDAC6 CD1 and CD2 (linker intact) in complex with Nexturastat A Descriptor: CHLORIDE ION, HDAC6, NEXTURASTAT A, ... Authors: Miyake, Y, Keusch, J.J, Wang, L, Saito, M, Hess, D, Wang, X, Melancon, B.J, Helquist, P, Gut, H, Matthias, P. Deposit date: 2016-03-18 Release date: 2016-07-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition Nat.Chem.Biol., 12, 2016

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