7LBM
| Structure of the human Mediator-bound transcription pre-initiation complex | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Abdella, R, Talyzina, A, He, Y. | Deposit date: | 2021-01-08 | Release date: | 2021-03-24 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structure of the human Mediator-bound transcription preinitiation complex. Science, 372, 2021
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8GXQ
| PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. | Deposit date: | 2022-09-21 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (5.04 Å) | Cite: | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
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5IYA
| Human core-PIC in the closed state | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | Deposit date: | 2016-03-24 | Release date: | 2016-05-18 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (5.4 Å) | Cite: | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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8WAK
| Structure of transcribing complex 2 (TC2), the initially transcribing complex with Pol II positioned 2nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-07 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (5.47 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAP
| Structure of transcribing complex 6 (TC6), the initially transcribing complex with Pol II positioned 6nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-08 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (5.85 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAN
| Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II positioned 4nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-07 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (6.07 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAS
| Structure of transcribing complex 9 (TC9), the initially transcribing complex with Pol II positioned 9nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-08 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (6.13 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAQ
| Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II positioned 7nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-08 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (6.29 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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5IY9
| Human holo-PIC in the initial transcribing state (no IIS) | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | Deposit date: | 2016-03-24 | Release date: | 2016-05-18 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (6.3 Å) | Cite: | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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8WAO
| Structure of transcribing complex 5 (TC5), the initially transcribing complex with Pol II positioned 5nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-07 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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7NW0
| RNA polymerase II pre-initiation complex with open promoter DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CDK-activating kinase assembly factor MAT1, ... | Authors: | Aibara, S, Schilbach, S, Cramer, P. | Deposit date: | 2021-03-16 | Release date: | 2021-05-05 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structures of mammalian RNA polymerase II pre-initiation complexes. Nature, 594, 2021
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7NVZ
| RNA polymerase II pre-initiation complex with closed promoter DNA in distal position | Descriptor: | CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | Authors: | Aibara, S, Schilbach, S, Cramer, P. | Deposit date: | 2021-03-16 | Release date: | 2021-05-05 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Structures of mammalian RNA polymerase II pre-initiation complexes. Nature, 594, 2021
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5IY6
| Human holo-PIC in the closed state | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | Deposit date: | 2016-03-24 | Release date: | 2016-05-18 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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6O9L
| Human holo-PIC in the closed state | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I. | Deposit date: | 2019-03-14 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. Nat.Struct.Mol.Biol., 26, 2019
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8WAR
| Structure of transcribing complex 8 (TC8), the initially transcribing complex with Pol II positioned 8nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-08 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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7NVY
| RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | Descriptor: | CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | Authors: | Aibara, S, Schilbach, S, Cramer, P. | Deposit date: | 2021-03-16 | Release date: | 2021-05-05 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (7.3 Å) | Cite: | Structures of mammalian RNA polymerase II pre-initiation complexes. Nature, 594, 2021
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5IY8
| Human holo-PIC in the initial transcribing state | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | Deposit date: | 2016-03-24 | Release date: | 2016-05-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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8WAL
| Structure of transcribing complex 3 (TC3), the initially transcribing complex with Pol II positioned 3nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-07 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (8.52 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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5IY7
| Human holo-PIC in the open state | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | Deposit date: | 2016-03-24 | Release date: | 2016-05-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (8.6 Å) | Cite: | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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2RNR
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1VD4
| Solution structure of the zinc finger domain of TFIIE alpha | Descriptor: | Transcription initiation factor IIE, alpha subunit, ZINC ION | Authors: | Okuda, M, Tanaka, A, Arai, Y, Satoh, M, Okamura, H, Nagadoi, A, Hanaoka, F, Ohkuma, Y, Nishimura, Y. | Deposit date: | 2004-03-18 | Release date: | 2004-10-05 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | A novel zinc finger structure in the large subunit of human general transcription factor TFIIE. J.Biol.Chem., 279, 2004
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2JTX
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2RNQ
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