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PDB: 15 results
6YW2
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic FG2216 and RaPID-derived cyclic peptide 3C (14-mer)
Descriptor:
Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2020-04-29
Release date:
2020-12-30
Last modified:
2024-01-24
Method:
X-RAY DIFFRACTION (2.14 Å)
Cite:
Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
6YW3
HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer)
Descriptor:
Egl nine homolog 1, GLYCEROL, Hypoxia-inducible factor 1-alpha, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2020-04-29
Release date:
2020-12-30
Last modified:
2024-01-24
Method:
X-RAY DIFFRACTION (2.279 Å)
Cite:
Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
6YW4
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Descriptor:
Egl nine homolog 1, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2020-04-29
Release date:
2020-12-30
Last modified:
2024-01-24
Method:
X-RAY DIFFRACTION (1.528 Å)
Cite:
Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
6YW1
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Descriptor:
2-OXOGLUTARIC ACID, BICARBONATE ION, Egl nine homolog 1, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2020-04-29
Release date:
2020-12-30
Last modified:
2024-01-24
Method:
X-RAY DIFFRACTION (1.46 Å)
Cite:
Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
5LB6
HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:
Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-15
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (1.7 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBE
HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:
BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-15
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (1.749 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBC
HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:
BICARBONATE ION, CHLORIDE ION, Egl nine homolog 1, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-15
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (1.816 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBB
HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:
BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-15
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (1.7 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5L9R
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG)
Descriptor:
Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-10
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (1.81 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LBF
HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:
BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-16
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (1.8995 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5L9B
HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Descriptor:
2-OXOGLUTARIC ACID, Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-10
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (1.95 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LAT
HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:
BICARBONATE ION, Egl nine homolog 1, GLYCEROL, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-15
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (1.9 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LA9
HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-2)
Descriptor:
Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-14
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (2.813 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5L9V
HIF prolyl hydroxylase 2 (PHD2-R281C/P317C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-1)
Descriptor:
Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-11
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (1.829 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LAS
HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3)
Descriptor:
Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:
Chowdhury, R
,
Schofield, C.J.
Deposit date:
2016-06-14
Release date:
2016-08-31
Last modified:
2024-01-10
Method:
X-RAY DIFFRACTION (2.1 Å)
Cite:
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
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數據於2024-09-04公開中