1RKL
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2LAT
| Solution structure of a Human minimembrane protein OST4 | Descriptor: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 | Authors: | Gayen, S, Kang, C. | Deposit date: | 2011-03-21 | Release date: | 2011-06-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex. Biochem.Biophys.Res.Commun., 409, 2011
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6EZN
| Cryo-EM structure of the yeast oligosaccharyltransferase (OST) complex | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wild, R, Kowal, J, Eyring, J, Ngwa, E.M, Aebi, M, Locher, K.P. | Deposit date: | 2017-11-16 | Release date: | 2018-01-17 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. Nat Commun, 13, 2022
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6C26
| The Cryo-EM structure of a eukaryotic oligosaccharyl transferase complex | Descriptor: | (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, ... | Authors: | Bai, L, Li, H. | Deposit date: | 2018-01-06 | Release date: | 2018-01-31 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The atomic structure of a eukaryotic oligosaccharyltransferase complex. Nature, 555, 2018
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6S7T
| Cryo-EM structure of human oligosaccharyltransferase complex OST-B | Descriptor: | (2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl dihydrogen phosphate, (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium, ... | Authors: | Ramirez, A.S, Kowal, J, Locher, K.P. | Deposit date: | 2019-07-05 | Release date: | 2019-12-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Science, 366, 2019
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6S7O
| Cryo-EM structure of human oligosaccharyltransferase complex OST-A | Descriptor: | (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, ... | Authors: | Ramirez, A.S, Kowal, J, Locher, K.P. | Deposit date: | 2019-07-05 | Release date: | 2019-12-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Science, 366, 2019
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6XCR
| NMR structure of Ost4 in DPC micelles | Descriptor: | Oligosaccharyltransferase | Authors: | Chaudhary, B.P. | Deposit date: | 2020-06-09 | Release date: | 2021-02-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR and MD simulations reveal the impact of the V23D mutation on the function of yeast oligosaccharyltransferase subunit Ost4. Glycobiology, 31, 2021
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6XCU
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7OCI
| Cryo-EM structure of yeast Ost6p containing oligosaccharyltransferase complex | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wild, R, Neuhaus, J.D, Eyring, J, Irobalieva, R.N, Kowal, J, Lin, C.W, Locher, K.P, Aebi, M. | Deposit date: | 2021-04-27 | Release date: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases. Glycobiology, 31, 2021
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8AGE
| Structure of yeast oligosaccharylransferase complex with acceptor peptide bound | Descriptor: | (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ... | Authors: | Ramirez, A.S, de Capitani, M, Pesciullesi, G, Kowal, J, Bloch, J.S, Irobalieva, R.N, Aebi, M, Reymond, J.L, Locher, K.P. | Deposit date: | 2022-07-19 | Release date: | 2022-12-07 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. Nat Commun, 13, 2022
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8AGB
| Structure of yeast oligosaccharylransferase complex with lipid-linked oligosaccharide bound | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ramirez, A.S, de Capitani, M, Pesciullesi, G, Kowal, J, Bloch, J.S, Irobalieva, R.N, Aebi, M, Reymond, J.L, Locher, K.P. | Deposit date: | 2022-07-19 | Release date: | 2022-12-07 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. Nat Commun, 13, 2022
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8AGC
| Structure of yeast oligosaccharylransferase complex with lipid-linked oligosaccharide and non-acceptor peptide bound | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ramirez, A.S, de Capitani, M, Pesciullesi, G, Kowal, J, Bloch, J.S, Irobalieva, R.N, Aebi, M, Reymond, J.L, Locher, K.P. | Deposit date: | 2022-07-19 | Release date: | 2022-12-07 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. Nat Commun, 13, 2022
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8B6L
| Subtomogram average of the human Sec61-TRAP-OSTA-translocon | Descriptor: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2, ... | Authors: | Gemmer, M, Fedry, J.M.M, Forster, F.G. | Deposit date: | 2022-09-27 | Release date: | 2022-12-07 | Last modified: | 2023-02-08 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Visualization of translation and protein biogenesis at the ER membrane. Nature, 614, 2023
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8PN9
| Structure of human oligosaccharyltransferase OST-A complex bound to NGI-1 | Descriptor: | (2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAENYL TRIHYDROGEN DIPHOSPHATE, (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium, ... | Authors: | Ramirez, A.S, Kowal, J, Locher, K.P. | Deposit date: | 2023-06-30 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappa B. Cell, 187, 2024
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