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3LBD	LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID Descriptor: (9cis)-retinoic acid, RETINOIC ACID RECEPTOR GAMMA Authors: Klaholz, B.P, Renaud, J.-P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE) Deposit date: 1998-02-04 Release date: 1999-03-02 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Conformational adaptation of agonists to the human nuclear receptor RAR gamma. Nat.Struct.Biol., 5, 1998
1D6N	TERNARY COMPLEX STRUCTURE OF HUMAN HGPRTASE, PRPP, MG2+, AND THE INHIBITOR HPP REVEALS THE INVOLVEMENT OF THE FLEXIBLE LOOP IN SUBSTRATE BINDING Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 3H-PYRAZOLO[4,3-D]PYRIMIDIN-7-OL, MAGNESIUM ION, ... Authors: Balendiran, G.K. Deposit date: 1999-10-14 Release date: 1999-12-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding. Protein Sci., 8, 1999
3LRE	Crystal Structure Analysis of Human Kinesin-8 Motor Domain Descriptor: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF18A, MAGNESIUM ION Authors: Brejc, K, Moores, C.A, Hartman, J. Deposit date: 2010-02-11 Release date: 2010-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Insight into the molecular mechanism of the multitasking kinesin-8 motor. Embo J., 29, 2010
3R22	Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I) Descriptor: N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide, Serine/threonine-protein kinase 6 Authors: Zhang, L, Fan, J, Chong, J.-H, Cesana, A, Tam, B, Gilson, C, Boykin, C, Wang, D, Marcotte, D, Le Brazidec, J.-Y, Aivazian, D, Piao, J, Lundgren, K, Hong, K, Vu, K, Nguyen, K. Deposit date: 2011-03-11 Release date: 2011-08-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I). Bioorg.Med.Chem.Lett., 21, 2011
1CWJ	HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN Descriptor: CYCLOSPORIN D, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A Authors: Mikol, V, Kallen, J, Taylor, P, Walkinshaw, M.D. Deposit date: 1998-05-25 Release date: 1998-08-26 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A. J.Mol.Biol., 283, 1998
3L6Y	Crystal structure of p120 catenin in complex with E-cadherin Descriptor: Catenin delta-1, E-cadherin Authors: Ishiyama, N, Lee, S.-H, Liu, S, Li, G.-Y, Smith, M.J, Reichardt, L.F, Ikura, M. Deposit date: 2009-12-27 Release date: 2010-04-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell(Cambridge,Mass.), 141, 2010
3RNU	Structural Basis of Cytosolic DNA Sensing by Innate Immune Receptors Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*GP*AP*GP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*CP*TP*CP*TP*TP*TP*GP*AP*TP*GP*GP*CP*C)-3'), ... Authors: Jin, T.C, Xiao, T. Deposit date: 2011-04-22 Release date: 2012-04-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor. Immunity, 36, 2012
1A9N	CRYSTAL STRUCTURE OF THE SPLICEOSOMAL U2B''-U2A' PROTEIN COMPLEX BOUND TO A FRAGMENT OF U2 SMALL NUCLEAR RNA Descriptor: RNA (5'-R(*CP*CP*UP*GP*GP*UP*AP*UP*UP*GP*CP*AP*GP*UP*AP*CP*CP*UP*CP*CP*AP*GP* GP*U)-3'), SPLICEOSOMAL U2B'', U2A' Authors: Price, S.R, Evans, P.R, Nagai, K. Deposit date: 1998-04-08 Release date: 1998-09-23 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA. Nature, 394, 1998
3HU1	Structure of p97 N-D1 R95G mutant in complex with ATPgS Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase Authors: Tang, W.-K. Deposit date: 2009-06-12 Release date: 2010-06-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.81 Å) Cite: A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. Embo J., 29, 2010
1AIN	CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTION Descriptor: ANNEXIN I, CALCIUM ION Authors: Kim, S.-H. Deposit date: 1992-06-03 Release date: 1993-07-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of human annexin I at 2.5 A resolution. Protein Sci., 2, 1993
3HQH	Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATHx-MacroH2ASBCpep1 Descriptor: MacroH2A, Speckle-type POZ protein, ZINC ION Authors: Zhuang, M, Schulman, B.A. Deposit date: 2009-06-06 Release date: 2009-10-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol.Cell, 36, 2009
3HU3	Structure of p97 N-D1 R155H mutant in complex with ATPgS Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase Authors: Tang, W.-K. Deposit date: 2009-06-12 Release date: 2010-06-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. Embo J., 29, 2010
3QQ7	Crystal Structure of the p97 N-terminal domain Descriptor: CHLORIDE ION, COBALT (II) ION, GLYCEROL, ... Authors: Haenzelmann, P, Schindelin, H. Deposit date: 2011-02-15 Release date: 2011-06-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Hierarchical Binding of Cofactors to the AAA ATPase p97. Structure, 19, 2011
3IVB	Structures of SPOP-Substrate Complexes: Insights into Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-MacroH2ASBCpep1 Descriptor: CHLORIDE ION, Core histone macro-H2A.1, Speckle-type POZ protein, ... Authors: Schulman, B.A, Miller, D.J, Calabrese, M.F, Seyedin, S. Deposit date: 2009-08-31 Release date: 2009-10-20 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure 9 To be Published
3Q6S	The crystal structure of the heterochromatin protein 1 beta chromoshadow domain complexed with a peptide from Shugoshin 1 Descriptor: Chromobox protein homolog 1, Shugoshin-like 1 Authors: Brautigam, C.A, Chaudhary, J, Yu, H. Deposit date: 2011-01-03 Release date: 2011-12-14 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. Mol Biol Cell, 22, 2011
3QBN	Structure of Human Aurora A in Complex with a diaminopyrimidine Descriptor: 5-chloro-N~4~-cyclopropyl-N~2~-[4-(2-methoxyethoxy)phenyl]pyrimidine-2,4-diamine, Serine/threonine-protein kinase 6 Authors: Gruetter, C, Simard, J.R, Rauh, D. Deposit date: 2011-01-13 Release date: 2012-01-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Identification of Ustilago maydis Aurora kinase as a novel antifungal target. Acs Chem.Biol., 6, 2011
3J0S	Remodeling of actin filaments by ADF cofilin proteins Descriptor: Actin, cytoplasmic 1, Cofilin-2 Authors: Galkin, V.E, Orlova, A, Kudryashov, D.S, Solodukhin, A, Reisler, E, Schroeder, G.F, Egelman, E.H. Deposit date: 2011-11-24 Release date: 2011-12-21 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (9 Å) Cite: Remodeling of actin filaments by ADF/cofilin proteins. Proc.Natl.Acad.Sci.USA, 108, 2011
1CWK	HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN Descriptor: CYCLOSPORIN D, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A Authors: Mikol, V, Kallen, J, Taylor, P, Walkinshaw, M.D. Deposit date: 1998-05-26 Release date: 1998-07-15 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A. J.Mol.Biol., 283, 1998
3L6X	Crystal structure of p120 catenin in complex with E-cadherin Descriptor: Catenin delta-1, E-cadherin, SULFATE ION Authors: Ishiyama, N, Lee, S.-H, Liu, S, Li, G.-Y, Smith, M.J, Reichardt, L.F, Ikura, M. Deposit date: 2009-12-27 Release date: 2010-04-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell(Cambridge,Mass.), 141, 2010
3L8J	Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity Descriptor: Programmed cell death protein 10 Authors: Li, X, Zhang, R, Zhang, H, He, Y, Ji, W, Min, W, Boggon, T.J. Deposit date: 2009-12-31 Release date: 2010-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. J.Biol.Chem., 285, 2010
3LH0	Crystal structure of the 53BP1 tandem tudor domain in complex with p53K372me2 Descriptor: DIMETHYLATED p53 LYSINE 372 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ... Authors: Roy, S, Kutateladze, T.G. Deposit date: 2010-01-21 Release date: 2010-03-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J.Mol.Biol., 398, 2010
1ANW	THE EFFECT OF METAL BINDING ON THE STRUCTURE OF ANNEXIN V AND IMPLICATIONS FOR MEMBRANE BINDING Descriptor: ANNEXIN V, CALCIUM ION Authors: Lewit-Bentley, A, Morera, S, Huber, R, Bodo, G. Deposit date: 1993-10-26 Release date: 1994-12-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The effect of metal binding on the structure of annexin V and implications for membrane binding. Eur.J.Biochem., 210, 1992
3THZ	Human MutSbeta complexed with an IDL of 6 bases (Loop6) and ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA Loop6 minus strand, DNA Loop6 plus strand, ... Authors: Yang, W. Deposit date: 2011-08-19 Release date: 2011-12-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4.3 Å) Cite: Mechanism of mismatch repair revealed by human MutS bound to unpaired DNA loops Nat.Struct.Mol.Biol., 19, 2012
1AJW	STRUCTURE OF RHOGDI: A C-TERMINAL BINDING DOMAIN TARGETS AN N-TERMINAL INHIBITORY PEPTIDE TO GTPASES, NMR, 20 STRUCTURES Descriptor: RHOGDI Authors: Rosen, M.K, Gosser, Y.Q. Deposit date: 1997-05-11 Release date: 1997-11-19 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases. Nature, 387, 1997
3L8I	Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity Descriptor: Programmed cell death protein 10 Authors: Li, X, Zhang, R, Zhang, H, He, Y, Ji, W, Min, W, Boggon, T.J. Deposit date: 2009-12-31 Release date: 2010-05-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. J.Biol.Chem., 285, 2010

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