7R88
 
 | | The structure of human ABCG5-I529W/ABCG8-WT | | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | | Authors: | Sun, Y, Li, X, Long, T. | | Deposit date: | 2021-06-26 | | Release date: | 2021-09-08 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7R8E
 | | The structure of human ABCG1 E242Q complexed with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, Isoform 4 of ATP-binding cassette sub-family G member 1, ... | | Authors: | Sun, Y, Li, X, Long, T. | | Deposit date: | 2021-06-26 | | Release date: | 2021-09-08 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7R89
 | | The structure of human ABCG5/ABCG8 purified from yeast | | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | | Authors: | Sun, Y, Li, X, Long, T. | | Deposit date: | 2021-06-26 | | Release date: | 2021-09-08 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7R87
 | | The structure of human ABCG5-WT/ABCG8-I419E | | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | | Authors: | Sun, Y, Li, X, Long, T. | | Deposit date: | 2021-06-26 | | Release date: | 2021-09-08 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7R8C
 | | The structure of human ABCG1 | | Descriptor: | Isoform 4 of ATP-binding cassette sub-family G member 1 | | Authors: | Sun, Y, Li, X, Long, T. | | Deposit date: | 2021-06-26 | | Release date: | 2021-09-08 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7RIT
 | | Drug-free A. baumannii MsbA | | Descriptor: | ATP-dependent lipid A-core flippase | | Authors: | Thelot, F, Liao, M. | | Deposit date: | 2021-07-20 | | Release date: | 2021-10-06 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (5.2 Å) | | Cite: | Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
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6ETI
 | | Structure of inhibitor-bound ABCG2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | | Authors: | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. | | Deposit date: | 2017-10-26 | | Release date: | 2018-04-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
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5C76
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3DHW
 | | Crystal structure of methionine importer MetNI | | Descriptor: | D-methionine transport system permease protein metI, Methionine import ATP-binding protein metN | | Authors: | Rees, D.C, Kaiser, J.T, Kadaba, N.S, Johnson, E, Lee, A.T. | | Deposit date: | 2008-06-18 | | Release date: | 2008-08-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation.
Science, 321, 2008
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6FFC
 | | Structure of an inhibitor-bound ABC transporter | | Descriptor: | ATP-binding cassette sub-family G member 2, ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate | | Authors: | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P. | | Deposit date: | 2018-01-06 | | Release date: | 2018-04-11 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
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5C73
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5B57
 | | Inward-facing conformation of ABC heme importer BhuUV from Burkholderia cenocepacia | | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, Hemin import ATP-binding protein HmuV, Putative hemin ABC transport system, ... | | Authors: | Naoe, Y, Nakamura, N, Doi, A, Shiro, Y, Sugimoto, H. | | Deposit date: | 2016-04-25 | | Release date: | 2016-11-16 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of bacterial haem importer complex in the inward-facing conformation
Nat Commun, 7, 2016
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6FN1
 | | Zosuquidar and UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Human-mouse chimeric ABCB1 (ABCBHM), UIC2 Antigen Binding Fragment Heavy Chain, ... | | Authors: | Alam, A, Locher, K.P. | | Deposit date: | 2018-02-02 | | Release date: | 2018-02-21 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3FH6
 | | Crystal structure of the resting state maltose transporter from E. coli | | Descriptor: | Maltose transport system permease protein malF, Maltose transport system permease protein malG, Maltose/maltodextrin import ATP-binding protein malK | | Authors: | Khare, D, Oldham, M.L, Orelle, C, Davidson, A.L, Chen, J. | | Deposit date: | 2008-12-08 | | Release date: | 2009-03-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (4.5 Å) | | Cite: | Alternating access in maltose transporter mediated by rigid-body rotations.
Mol.Cell, 33, 2009
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5AWG
 | | Crystal structure of Hg-bound SufB-SufC-SufD complex from Escherichia coli | | Descriptor: | FeS cluster assembly protein SufB, FeS cluster assembly protein SufD, MERCURY (II) ION, ... | | Authors: | Hirabayashi, K, Wada, K. | | Deposit date: | 2015-07-03 | | Release date: | 2015-11-11 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (4.278 Å) | | Cite: | Functional Dynamics Revealed by the Structure of the SufBCD Complex, a Novel ATP-binding Cassette (ABC) Protein That Serves as a Scaffold for Iron-Sulfur Cluster Biogenesis
J.Biol.Chem., 290, 2015
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5C78
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6GDI
 | | Structure of P-glycoprotein(ABCB1) in the post-hydrolytic state | | Descriptor: | Multidrug resistance protein 1A | | Authors: | Ford, R.C, Thonghin, N, Collins, R.F, Barbieri, A, Shafi, T, Siebert, A. | | Deposit date: | 2018-04-23 | | Release date: | 2018-05-23 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (7.9 Å) | | Cite: | Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 angstrom resolution.
Bmc Struct.Biol., 18, 2018
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6FN4
 | | Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM) | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Apo form of Human-mouse chimeric ABCB1 (ABCB1HM) in complex with Antigen binding fragment of UIC2., ... | | Authors: | Alam, A, Locher, K.P. | | Deposit date: | 2018-02-02 | | Release date: | 2018-02-21 | | Last modified: | 2021-06-02 | | Method: | ELECTRON MICROSCOPY (4.14 Å) | | Cite: | Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FNP
 | | Crystal structure of ECF-CbrT, a cobalamin transporter | | Descriptor: | Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, Energy-coupling factor transporter transmembrane protein EcfT, ... | | Authors: | Santos, J.A, Rempel, S, Guskov, A, Slotboom, D.J. | | Deposit date: | 2018-02-05 | | Release date: | 2018-07-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Functional and structural characterization of an ECF-type ABC transporter for vitamin B12.
Elife, 7, 2018
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6FEQ
 | | Structure of inhibitor-bound ABCG2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | | Authors: | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. | | Deposit date: | 2018-01-03 | | Release date: | 2018-04-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
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3FVQ
 | | Crystal structure of the nucleotide binding domain FbpC complexed with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Fe(3+) ions import ATP-binding protein fbpC | | Authors: | Newstead, S, Bilton, P, Carpenter, E.P, Campopiano, D, Iwata, S. | | Deposit date: | 2009-01-16 | | Release date: | 2009-08-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Insights into how nucleotide-binding domains power ABC transport.
Structure, 17, 2009
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3G60
 | | Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding | | Descriptor: | (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1a | | Authors: | Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G. | | Deposit date: | 2009-02-05 | | Release date: | 2009-03-24 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (4.4 Å) | | Cite: | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
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3GD7
 | | Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP) | | Descriptor: | Fusion complex of Cystic fibrosis transmembrane conductance regulator, residues 1193-1427 and Maltose/maltodextrin import ATP-binding protein malK, residues 219-371, ... | | Authors: | Atwell, S, Antonysamy, S, Conners, K, Emtage, S, Gheyi, T, Lewis, H.A, Lu, F, Sauder, J.M, Wasserman, S.R, Zhao, X. | | Deposit date: | 2009-02-23 | | Release date: | 2010-03-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
To be Published
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3G5U
 | | Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding | | Descriptor: | MERCURY (II) ION, Multidrug resistance protein 1a | | Authors: | Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G. | | Deposit date: | 2009-02-05 | | Release date: | 2009-03-24 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
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5B58
 | | Inward-facing conformation of ABC heme importer BhuUV in complex with periplasmic heme binding protein BhuT from Burkholderia cenocepacia | | Descriptor: | Hemin import ATP-binding protein HmuV, Putative hemin ABC transport system, membrane protein, ... | | Authors: | Naoe, Y, Nakamura, N, Doi, A, Shiro, Y, Sugimoto, H. | | Deposit date: | 2016-04-25 | | Release date: | 2016-11-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.21 Å) | | Cite: | Crystal structure of bacterial haem importer complex in the inward-facing conformation
Nat Commun, 7, 2016
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