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8ZFL	Caenorhabditis elegans ACR-23 in apo state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betaine receptor acr-23,Soluble cytochrome b562 Authors: Chen, Q.F, Liu, F.L, Li, T.Y, Gong, H.H, Guo, F, Liu, S. Deposit date: 2024-05-08 Release date: 2024-07-31 Method: ELECTRON MICROSCOPY (2.61 Å) Cite: Structural basis of acetylcholine receptor like-23 (ACR-23) activation by anthelmintics monepantel and betaine To Be Published
9F4Z	UP1 in complex with Z57040482 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-(2-hydroxyphenyl)acetamide Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F55	UP1 in complex with Z235361315 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, ~{N}-(3-azanyl-2-methyl-phenyl)propanamide Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
8ZJM	Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 5) Descriptor: Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 Authors: Kukimoto-Niino, M, Katsura, K, Ishizuka-Katsura, Y, Mishima-Tsumagari, C, Yonemochi, M, Inoue, M, Nakagawa, R, Kaushik, R, Zhang, K.Y.J, Shirouzu, M. Deposit date: 2024-05-15 Release date: 2024-06-26 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.52 Å) Cite: RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state. J.Biol.Chem., 300, 2024
9ICL	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF PYROPHOSPHATE AND MNCL2 Descriptor: DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), MANGANESE (II) ION, ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1996-01-04 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis Biochemistry, 35, 1996
9F4F	UP1 in complex with Z86417414 Descriptor: 2-fluoranyl-~{N}-(1,3,4-thiadiazol-2-yl)benzamide, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-27 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9ICH	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DGTP (1 MILLIMOLAR) AND ZNCL2 (1 MILLIMOLAR) Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. Biochemistry, 35, 1996
9F4O	UP1 in complex with Z991506900 Descriptor: (3~{R})-3-methyl-1-(6-methylpyridin-2-yl)piperazine, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F4Y	UP1 in complex with Z90120418 Descriptor: 1-(3,4,5-trimethoxyphenyl)methanamine, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9BRY	V0-only V-ATPase in synaptophysin gene knock-out mouse brain isolated synaptic vesicles Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. Deposit date: 2024-05-12 Release date: 2024-06-19 Last modified: 2024-08-07 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structure and topography of the synaptic V-ATPase-synaptophysin complex. Nature, 631, 2024
8ZJJ	Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 2) Descriptor: Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 Authors: Kukimoto-Niino, M, Katsura, K, Ishizuka-Katsura, Y, Mishima-Tsumagari, C, Yonemochi, M, Inoue, M, Nakagawa, R, Kaushik, R, Zhang, K.Y.J, Shirouzu, M. Deposit date: 2024-05-15 Release date: 2024-06-26 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.23 Å) Cite: RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state. J.Biol.Chem., 300, 2024
9ICV	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DATP AND ZNCL2 Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*A)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-16 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
9CC3	Human Mitochondrial LONP1 Stall State + casein Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endogenous Co-purified substrate modeled as unknown residues, Lon protease homolog, ... Authors: Mindrebo, J.T, Lander, G.C. Deposit date: 2024-06-20 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism. Biorxiv, 2024
9F5E	UP1 in complex with Z30820160 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-(4-methyl-1,3-thiazol-2-yl)propanamide Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9CL9	WT 12C IM fraction, B-b3 with RluB bound Descriptor: 23S rRNA, Large ribosomal subunit protein bL20, Large ribosomal subunit protein bL21, ... Authors: Lee, J, Sheng, K, Williamson, J.R. Deposit date: 2024-07-10 Release date: 2024-07-24 Method: ELECTRON MICROSCOPY (5.04 Å) Cite: 50S ribosome assembly intermediates at low temperature reveal bound RluB To Be Published
8YAX	SARS-CoV-2 DMV nsp3-4 pore complex (full-pore) Descriptor: Non-structural protein 4, Papain-like protease nsp3 Authors: Huang, Y.X, Zhong, L.J, Zhang, W.X, Ni, T. Deposit date: 2024-02-10 Release date: 2024-06-19 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Molecular Architecture of Coronavirus Double Membrane Vesicle Pore Complex To Be Published
8XCG	Tail tip complex of bacteriophage lambda in the open state Descriptor: IRON/SULFUR CLUSTER, Tail tip assembly protein I, Tail tip protein L, ... Authors: Ge, X.F, Wang, J.W. Deposit date: 2023-12-09 Release date: 2024-05-01 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Structural mechanism of bacteriophage lambda tail's interaction with the bacterial receptor. Nat Commun, 15, 2024
8YC0	T cell receptor V delta2 V gamma9 in GDN Descriptor: CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... Authors: Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. Deposit date: 2024-02-17 Release date: 2024-05-08 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (4.12 Å) Cite: Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
9CC0	Human Mitochondrial LONP1 Degrading Casein, ATP-bound closed form Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bound substrate segment undergoing translocation and subsequent degradation, ... Authors: Mindrebo, J.T, Lander, G.C. Deposit date: 2024-06-20 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (3.31 Å) Cite: Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism. Biorxiv, 2024
9F4K	UP1 in complex with ZINC72259689 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, ~{N}-(cyclobutylmethyl)-1,3-dimethyl-pyrazole-4-carboxamide Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
8ZFK	Caenorhabditis elegans ACR-23 in betaine and monepantel bound state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betaine receptor acr-23,Soluble cytochrome b562, ... Authors: Chen, Q.F, Liu, F.L, Li, T.Y, Gong, H.H, Guo, F, Liu, S. Deposit date: 2024-05-08 Release date: 2024-07-31 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: Structural basis of acetylcholine receptor like-23 (ACR-23) activation by anthelmintics monepantel and betaine To Be Published
9C0Y	Clathrin terminal domain complexed with Pitstop 2c Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ... Authors: Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. Deposit date: 2024-05-28 Release date: 2024-06-26 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function To Be Published
9F4G	UP1 in complex with Z1373445602 Descriptor: 4-(3-fluoranylpyridin-2-yl)-1-methyl-piperazin-2-one, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-27 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F4T	UP1 in complex with EN300-805013 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-(4-methoxyphenyl)glycinamide Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
8ZPJ	EcGK bundle at APO state. Descriptor: Glutamate 5-kinase Authors: Zhang, T, Leng, Q, Liu, L.J. Deposit date: 2024-05-30 Release date: 2024-07-31 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: EcGPR tetramer with catalytic intermediates To Be Published

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