8UQZ
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![BU of 8uqz by Molmil](/molmil-images/mine/8uqz) | Round 18 Arylesterase Variant of Phosphotriesterase Bound to Gadolinium(III) Measured at 9.5 keV | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, GADOLINIUM ION, ... | Authors: | Breeze, C.W, Frkic, R.L, Campbell, E.C, Jackson, C.J. | Deposit date: | 2023-10-25 | Release date: | 2024-04-03 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Mononuclear binding and catalytic activity of europium(III) and gadolinium(III) at the active site of the model metalloenzyme phosphotriesterase. Acta Crystallogr D Struct Biol, 80, 2024
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1YWH
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![BU of 1ywh by Molmil](/molmil-images/mine/1ywh) | crystal structure of urokinase plasminogen activator receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Llinas, P, Le Du, M.H, Gardsvoll, H, Dano, K, Ploug, M, Gilquin, B, Stura, E.A, Menez, A. | Deposit date: | 2005-02-18 | Release date: | 2005-05-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide EMBO J., 24, 2005
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8UUU
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![BU of 8uuu by Molmil](/molmil-images/mine/8uuu) | SARS-Cov-2 papain-like protease (PLpro) with inhibitor Jun12162 | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | Deposit date: | 2023-11-02 | Release date: | 2024-04-03 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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5MRG
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![BU of 5mrg by Molmil](/molmil-images/mine/5mrg) | Solution structure of TDP-43 (residues 1-102) | Descriptor: | TAR DNA-binding protein 43 | Authors: | Mompean, M, Romano, V, Pantoja-Uceda, D, Stuani, C, Baralle, F.E, Laurents, D.V. | Deposit date: | 2016-12-22 | Release date: | 2017-06-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions. J. Biol. Chem., 292, 2017
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6NRP
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![BU of 6nrp by Molmil](/molmil-images/mine/6nrp) | Putative short-chain dehydrogenase/reductase (SDR) from Acinetobacter baumannii | Descriptor: | 3-oxoacyl-ACP reductase FabG | Authors: | Cross, E.M, Smith, K.M, Shaw, K.I, Aragao, D, Forwood, J.K. | Deposit date: | 2019-01-23 | Release date: | 2019-02-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Insights into Acinetobacter baumannii fatty acid synthesis 3-oxoacyl-ACP reductases. Sci Rep, 11, 2021
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6S0G
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![BU of 6s0g by Molmil](/molmil-images/mine/6s0g) | Crystal structure of ene-reductase GsOYE from Galdieria sulphuraria | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ... | Authors: | Robescu, M.R, Niero, M, Hall, M, Bergantino, E, Cendron, L. | Deposit date: | 2019-06-14 | Release date: | 2020-01-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Two new ene-reductases from photosynthetic extremophiles enlarge the panel of old yellow enzymes: CtOYE and GsOYE. Appl.Microbiol.Biotechnol., 104, 2020
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6CHN
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![BU of 6chn by Molmil](/molmil-images/mine/6chn) | Phosphopantetheine adenylyltransferase (CoaD) in complex with methyl (R)-4-(3-(2-cyano-1-((5-methyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino)ethyl)phenoxy)piperidine-1-carboxylate | Descriptor: | DI(HYDROXYETHYL)ETHER, Phosphopantetheine adenylyltransferase, SULFATE ION, ... | Authors: | Mamo, M, Appleton, B.A. | Deposit date: | 2018-02-22 | Release date: | 2018-04-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity. J. Med. Chem., 61, 2018
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6S0Z
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![BU of 6s0z by Molmil](/molmil-images/mine/6s0z) | Erythromycin Resistant Staphylococcus aureus 50S ribosome (delta R88 A89 uL22) in complex with erythromycin. | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Halfon, Y, Matozv, D, Eyal, Z, Bashan, A, Zimmerman, E, Kjeldgaard, J, Ingmer, H, Yonath, A. | Deposit date: | 2019-06-18 | Release date: | 2019-08-21 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant. Sci Rep, 9, 2019
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2VO2
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![BU of 2vo2 by Molmil](/molmil-images/mine/2vo2) | Crystal structure of soybean ascorbate peroxidase mutant W41A subjected to low dose X-rays | Descriptor: | ASCORBATE PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ... | Authors: | Metcalfe, C.L, Badyal, S.K, Raven, E.L, Moody, P.C.E. | Deposit date: | 2008-02-08 | Release date: | 2008-04-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Iron Oxidation State Modulates Active Site Structure in a Heme Peroxidase. Biochemistry, 47, 2008
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1ZBA
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![BU of 1zba by Molmil](/molmil-images/mine/1zba) | Foot-and-Mouth Disease virus serotype A1061 complexed with oligosaccharide receptor. | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Coat protein VP1, Coat protein VP2, ... | Authors: | Fry, E.E, Newman, J.W, Curry, S, Najjam, S, Jackson, T, Blakemore, W, Lea, S.M, Miller, L, Burman, A, King, A.M, Stuart, D.I. | Deposit date: | 2005-04-08 | Release date: | 2005-06-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of Foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation. J.Gen.Virol., 86, 2005
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1CCL
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![BU of 1ccl by Molmil](/molmil-images/mine/1ccl) | |
3J34
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![BU of 3j34 by Molmil](/molmil-images/mine/3j34) | Structure of HIV-1 Capsid Protein by Cryo-EM | Descriptor: | capsid protein | Authors: | Zhao, G, Perilla, J.R, Yufenyuy, E, Meng, X, Chen, B, Ning, J, Ahn, J, Gronenborn, A.M, Schulten, K, Aiken, C, Zhang, P. | Deposit date: | 2013-02-23 | Release date: | 2013-05-29 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (8.6 Å) | Cite: | Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics. Nature, 497, 2013
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6CCV
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![BU of 6ccv by Molmil](/molmil-images/mine/6ccv) | Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Rifampicin | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2018-02-07 | Release date: | 2018-08-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
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8UQX
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![BU of 8uqx by Molmil](/molmil-images/mine/8uqx) | Round 18 Arylesterase Variant of Apo-Phosphotriesterase Measured at 9.5 keV | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Phosphotriesterase variant PTE-R18 | Authors: | Breeze, C.W, Frkic, R.L, Campbell, E.C, Jackson, C.J. | Deposit date: | 2023-10-25 | Release date: | 2024-04-03 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Mononuclear binding and catalytic activity of europium(III) and gadolinium(III) at the active site of the model metalloenzyme phosphotriesterase. Acta Crystallogr D Struct Biol, 80, 2024
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1NA4
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![BU of 1na4 by Molmil](/molmil-images/mine/1na4) | The structure of immature Yellow Fever virus particle | Descriptor: | major envelope protein E | Authors: | Zhang, Y, Corver, J, Chipman, P.R, Lenches, E, Zhang, W, Pletnev, S.V, Sedlak, D, Baker, T.S, Strauss, J.H, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2002-11-26 | Release date: | 2003-12-09 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY | Cite: | Structures of immature flavivirus particles EMBO J., 22, 2003
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8V84
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![BU of 8v84 by Molmil](/molmil-images/mine/8v84) | 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map) | Descriptor: | 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ... | Authors: | Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P. | Deposit date: | 2023-12-04 | Release date: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. Nat Commun, 15, 2024
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2ATP
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![BU of 2atp by Molmil](/molmil-images/mine/2atp) | Crystal structure of a CD8ab heterodimer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain, ... | Authors: | Chang, H.C, Tan, K, Ouyang, J, Parisini, E, Liu, J.H, Le, Y, Wang, X, Reinherz, E.L, Wang, J.H. | Deposit date: | 2005-08-25 | Release date: | 2005-12-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Mutational Analyses of a CD8alphabeta Heterodimer and Comparison with the CD8alphaalpha Homodimer. Immunity, 23, 2005
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3ZXW
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![BU of 3zxw by Molmil](/molmil-images/mine/3zxw) | STRUCTURE OF ACTIVATED RUBISCO FROM THERMOSYNECHOCOCCUS ELONGATUS COMPLEXED WITH 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE | Descriptor: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Terlecka, B, Wilhelmi, V, Bialek, W, Gubernator, B, Szczepaniak, A, Hofmann, E. | Deposit date: | 2011-08-16 | Release date: | 2012-08-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of Ribulose-1,5-Bisphosphate Carboxylase Oxygenase from Thermosynechococcus Elongatus To be Published
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7RPR
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![BU of 7rpr by Molmil](/molmil-images/mine/7rpr) | Borrelia miyamotoi FbpA complement inhibitory domain | Descriptor: | Fibronectin-binding lipoprotein FbpA | Authors: | Booth, C.E, Garcia, B.L. | Deposit date: | 2021-08-04 | Release date: | 2022-04-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Borrelia miyamotoi FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and Functions. Front Immunol, 13, 2022
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3E1P
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![BU of 3e1p by Molmil](/molmil-images/mine/3e1p) | Crystal structure of E. coli Bacterioferritin (BFR) in which the Ferroxidase centre is inhibited with ZN(II) and high occupancy iron is bound within the cavity. | Descriptor: | BACTERIOFERRITIN, FE (II) ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Crow, A, Lawson, T, Lewin, A, Moore, G.R, Le Brun, N. | Deposit date: | 2008-08-04 | Release date: | 2009-05-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for iron mineralization by bacterioferritin J.Am.Chem.Soc., 131, 2009
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6NFY
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![BU of 6nfy by Molmil](/molmil-images/mine/6nfy) | Crystal structure of nonphosphorylated, HPK1 kinase domain in complex with sunitinib in the inactive state. | Descriptor: | Mitogen-activated protein kinase kinase kinase kinase 1, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide | Authors: | Johnson, E, McTigue, M, Cronin, C.N. | Deposit date: | 2018-12-21 | Release date: | 2019-05-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation. J.Biol.Chem., 294, 2019
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3N01
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![BU of 3n01 by Molmil](/molmil-images/mine/3n01) | |
8UVM
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![BU of 8uvm by Molmil](/molmil-images/mine/8uvm) | SARS-CoV-2 papain-like protease (PLpro) complex with covalent inhibitor Jun11313 | Descriptor: | CHLORIDE ION, Papain-like protease nsp3, SULFATE ION, ... | Authors: | Ansari, A, Tan, B, Chopra, A, Ruiz, F.X, Arnold, E, Wang, J. | Deposit date: | 2023-11-03 | Release date: | 2024-04-03 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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3ZD4
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7LDY
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![BU of 7ldy by Molmil](/molmil-images/mine/7ldy) | HIV-1 Protease WT (NL4-3) in Complex with TMC-126 | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE, Protease, SULFATE ION | Authors: | Lockbaum, G.J, Rusere, L.N, Henes, M, Kosovrasti, K, Lee, S.K, Spielvogel, E, Nalivaika, E.A, Swanstrom, R, KurtYilmaz, N, Schiffer, C.A, Ali, A. | Deposit date: | 2021-01-14 | Release date: | 2022-07-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.984 Å) | Cite: | HIV-1 Protease Inhibitors with a P1 Phosphonate Modification Maintain Potency against Drug Resistant Variants by Increased van der Waals Contacts with Flaps Residues To Be Published
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