PDB: 464 resultsInfo pagesStatus searchChemie searchBIRD

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4XE2	N-terminal domain of Hsp90 from Dictyostelium discoideum in complex with peptide Descriptor: Heat shock cognate 90 kDa protein Authors: Raman, S, Suguna, K. Deposit date: 2014-12-22 Release date: 2015-12-02 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.199 Å) Cite: First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90. Sci Rep, 5, 2015
4XKA	N-terminal domain of Hsp90 from Dictyostelium discoideum in hexagonal form with glycerol Descriptor: GLYCEROL, Heat shock cognate 90 kDa protein, TRIS(HYDROXYETHYL)AMINOMETHANE Authors: Raman, S, Suguna, K. Deposit date: 2015-01-10 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90 Sci Rep, 5, 2015
4XD8	N-terminal domain of Hsp90 from Dictyostelium discoideum in complex with ANP Descriptor: Heat shock cognate 90 kDa protein, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Raman, S, Suguna, K. Deposit date: 2014-12-19 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.55 Å) Cite: First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90 Sci Rep, 5, 2015
4XKK	Crystal structure of N-terminal domain of Hsp90 from Dictyostelium discoideum Descriptor: Heat shock cognate 90 kDa protein Authors: Raman, S, Suguna, K. Deposit date: 2015-01-12 Release date: 2015-01-28 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Heat shock protein 90 regulates development in Dictyostelium discoideum J. Mol. Biol., 383, 2008
4XKO	N-terminal domain of Hsp90 from Dictyostelium discoideum in hexagonal form with PEG Descriptor: DI(HYDROXYETHYL)ETHER, Heat shock cognate 90 kDa protein, TRIS(HYDROXYETHYL)AMINOMETHANE Authors: Raman, S, Suguna, K. Deposit date: 2015-01-12 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.455 Å) Cite: First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90 Sci Rep, 5, 2015
4ZKI	The crystal structure of Histidine Kinase YycG with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, Histidine kinase Authors: Cai, Y. Deposit date: 2015-04-30 Release date: 2016-05-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.401 Å) Cite: Conformational dynamics of the essential sensor histidine kinase WalK Acta Crystallogr D Struct Biol, 73, 2017
2BRE	STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90. Descriptor: 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 Authors: Roe, S.M, Pearl, L.H, Prodromou, C. Deposit date: 2005-05-04 Release date: 2005-09-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg. Med. Chem. Lett., 15, 2005
2BRC	Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90. Descriptor: 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 Authors: Roe, S.M, Pearl, L.H, Prodromou, C. Deposit date: 2005-05-04 Release date: 2005-09-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg. Med. Chem. Lett., 15, 2005
2CGF	A RADICICOL ANALOGUE BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE Descriptor: (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 Authors: Roe, S.M, Prodromou, C, Pearl, L.H, Moody, C.J. Deposit date: 2006-03-02 Release date: 2006-11-29 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13, 2006
2AKP	Hsp90 Delta24-N210 mutant Descriptor: ATP-dependent molecular chaperone HSP82 Authors: Richter, K, Moser, S, Hagn, F, Friedrich, R, Hainzl, O, Heller, M, Schlee, S, Kessler, H, Reinstein, J, Buchner, J. Deposit date: 2005-08-03 Release date: 2006-01-31 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Intrinsic inhibition of the Hsp90 ATPase activity. J.Biol.Chem., 281, 2006
1YS3	Crystal Structure of the ATP binding domain of PrrB from Mycobacterium Tuberculosis Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Sensor-type histidine kinase prrB Authors: Nowak, E, Panjikar, S, Tucker, P, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) Deposit date: 2005-02-07 Release date: 2005-07-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of ATP binding domain of Hidtidine Kinase from MTB To be Published
1YSR	Crystal Structure of ATP binding domain of PrrB from Mycobacterium Tuberculosis Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Sensor-type histidine kinase prrB Authors: Nowak, E, Panjikar, S, Tucker, P, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) Deposit date: 2005-02-09 Release date: 2005-07-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Crystal Structure of ATP binding domain of PrrB from Mycobacterium Tuberculosis To be published
1ZWH	Yeast Hsp82 in complex with the novel Hsp90 inhibitor Radester amine Descriptor: 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE, ATP-dependent molecular chaperone HSP82 Authors: Immormino, R.M, Blagg, B.S, Gewirth, D.T. Deposit date: 2005-06-03 Release date: 2006-06-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design To be Published
1ZW9	Yeast HSP82 in complex with the Novel HSP90 Inhibitor 8-(6-Bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine Descriptor: 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE, HSP82 Authors: Immormino, R.M, Gewirth, D.T, Chiosis, G. Deposit date: 2005-06-03 Release date: 2006-06-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design To be Published
3EHG	Crystal structure of the ATP-binding domain of DesK in complex with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, IODIDE ION, MAGNESIUM ION, ... Authors: Trajtenberg, F, Buschiazzo, A. Deposit date: 2008-09-12 Release date: 2009-09-15 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Structural and enzymatic insights into the ATP binding and autophosphorylation mechanism of a sensor histidine kinase J.Biol.Chem., 285, 2010
3CGZ	Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain Descriptor: Virulence sensor histidine kinase phoQ Authors: Guarnieri, M.T, Zhang, L, Shen, J, Zhao, R. Deposit date: 2008-03-06 Release date: 2008-05-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J.Mol.Biol., 379, 2008
3CGY	Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain in complex with radicicol Descriptor: RADICICOL, Virulence sensor histidine kinase phoQ Authors: Guarnieri, M.T, Zhang, L, Shen, J, Zhao, R. Deposit date: 2008-03-06 Release date: 2008-05-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J.Mol.Biol., 379, 2008
3G7B	Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor Descriptor: DNA gyrase subunit B, methyl ({5-[4-(4-hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1H-pyrazol-3-yl}methyl)carbamate Authors: Wei, Y, Charisfon, P. Deposit date: 2009-02-09 Release date: 2010-02-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20, 2010
3FV5	Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor Descriptor: 1-(4-acetyl-6-pyridin-3-yl-1H-benzimidazol-2-yl)-3-ethylurea, DNA topoisomerase 4 subunit B Authors: Wei, Y, Charifson, P, LeTiran, A. Deposit date: 2009-01-15 Release date: 2010-01-26 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity To be Published
3G7E	Crystal structure of E. coli Gyrase B co-complexed with PROP-2-YN-1-YL {[5-(4-PIPERIDIN-1-YL-2-PYRIDIN-3-YL-1,3-THIAZOL-5-YL)-1H-PYRAZOL-3-YL]METHYL}CARBAMATE inhibitor Descriptor: DNA gyrase subunit B, prop-2-yn-1-yl {[5-(4-piperidin-1-yl-2-pyridin-3-yl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methyl}carbamate Authors: Wei, Y, Charifson, P. Deposit date: 2009-02-09 Release date: 2010-02-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20, 2010
3G75	Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor Descriptor: 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole, DNA gyrase subunit B Authors: Wei, Y, Charifson, P. Deposit date: 2009-02-09 Release date: 2010-02-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20, 2010
3A0Y	Catalytic domain of histidine kinase ThkA (TM1359) (nucleotide free form 3: 1,2-propanediol, orthorombic) Descriptor: Sensor protein Authors: Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. Deposit date: 2009-03-25 Release date: 2009-10-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009
3A0W	Catalytic domain of histidine kinase ThkA (TM1359) for MAD phasing (nucleotide free form 2, orthorombic) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(ETHYLMERCURI-THIO)-BENZOIC ACID, ETHYL MERCURY ION, ... Authors: Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. Deposit date: 2009-03-24 Release date: 2009-10-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009
3A0X	Catalytic domain of histidine kinase ThkA (TM1359) (nucleotide free form 1: ammomium phosphate, monoclinic) Descriptor: Sensor protein Authors: Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. Deposit date: 2009-03-25 Release date: 2009-10-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009
3A0T	Catalytic domain of histidine kinase ThkA (TM1359) in complex with ADP and Mg ion (trigonal) Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Sensor protein Authors: Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. Deposit date: 2009-03-24 Release date: 2009-10-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009

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