8J57
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in complex with bedaquiline(BDQ) | Descriptor: | ATP synthase subunit a, ATP synthase subunit c, Bedaquiline | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-04-21 | Release date: | 2024-05-01 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8J58
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in the apo-form | Descriptor: | ATP synthase subunit a, ATP synthase subunit c | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-04-21 | Release date: | 2024-05-01 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8J0S
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with bedaquiline(BDQ) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-04-11 | Release date: | 2024-05-22 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8JR0
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with TBAJ-587 | Descriptor: | (1~{S},2~{S})-1-(6-bromanyl-2-methoxy-quinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2-fluoranyl-3-methoxy-phenyl)butan-2-ol, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-06-15 | Release date: | 2024-05-01 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8KHF
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8JR1
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in complex with TBAJ-587 | Descriptor: | (1~{S},2~{S})-1-(6-bromanyl-2-methoxy-quinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2-fluoranyl-3-methoxy-phenyl)butan-2-ol, ATP synthase subunit a, ATP synthase subunit c | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-06-15 | Release date: | 2024-05-01 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8KI3
| Structure of the human ATP synthase bound to bedaquiline (composite) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F(0) complex subunit B1, ... | Authors: | Lai, Y, Zhang, Y, Gong, H. | Deposit date: | 2023-08-22 | Release date: | 2024-05-01 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8J0T
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in the apo-form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-04-11 | Release date: | 2024-05-22 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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5ARH
| Bovine mitochondrial ATP synthase state 2a | Descriptor: | ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL, ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, ... | Authors: | Zhou, A, Rohou, A, Schep, D.G, Bason, J.V, Montgomery, M.G, Walker, J.E, Grigorieff, N, Rubinstein, J.L. | Deposit date: | 2015-09-24 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife, 4, 2015
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5ARA
| Bovine mitochondrial ATP synthase state 1a | Descriptor: | ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL, ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, ... | Authors: | Zhou, A, Rohou, A, Schep, D.G, Bason, J.V, Montgomery, M.G, Walker, J.E, Grigorieff, N, Rubinstein, J.L. | Deposit date: | 2015-09-24 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife, 4, 2015
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5ARI
| Bovine mitochondrial ATP synthase state 2b | Descriptor: | ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL, ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, ... | Authors: | Zhou, A, Rohou, A, Schep, D.G, Bason, J.V, Montgomery, M.G, Walker, J.E, Grigorieff, N, Rubinstein, J.L. | Deposit date: | 2015-09-24 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife, 4, 2015
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5ARE
| Bovine mitochondrial ATP synthase state 1b | Descriptor: | ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL, ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, ... | Authors: | Zhou, A, Rohou, A, Schep, D.G, Bason, J.V, Montgomery, M.G, Walker, J.E, Grigorieff, N, Rubinstein, J.L. | Deposit date: | 2015-09-24 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife, 4, 2015
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5DN6
| ATP synthase from Paracoccus denitrificans | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F0 subcomplex C subunit, ... | Authors: | Morales-Rios, E, Montgomery, M.G, Leslie, A.G.W, Walker, J.E. | Deposit date: | 2015-09-09 | Release date: | 2015-10-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.98 Å) | Cite: | Structure of ATP synthase from Paracoccus denitrificans determined by X-ray crystallography at 4.0 angstrom resolution. Proc.Natl.Acad.Sci.USA, 112, 2015
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6WM2
| Human V-ATPase in state 1 with SidK and ADP | Descriptor: | (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid, 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wang, L, Wu, H, Fu, T.M. | Deposit date: | 2020-04-20 | Release date: | 2020-11-11 | Last modified: | 2020-11-25 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Mol.Cell, 80, 2020
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6WM3
| Human V-ATPase in state 2 with SidK and ADP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, Renin receptor, ... | Authors: | Wang, L, Wu, H, Fu, T.M. | Deposit date: | 2020-04-20 | Release date: | 2020-11-11 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Mol.Cell, 80, 2020
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6WNQ
| E. coli ATP Synthase State 2a | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Stewart, A.G, Sobti, M, Walshe, J.L. | Deposit date: | 2020-04-23 | Release date: | 2020-06-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures provide insight into how E. coli F1FoATP synthase accommodates symmetry mismatch. Nat Commun, 11, 2020
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6WNR
| E. coli ATP synthase State 3b | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Stewart, A.G, Sobti, M, Walshe, J.L. | Deposit date: | 2020-04-23 | Release date: | 2020-06-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures provide insight into how E. coli F1FoATP synthase accommodates symmetry mismatch. Nat Commun, 11, 2020
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6XBY
| Cryo-EM structure of V-ATPase from bovine brain, state 2 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Wang, R, Li, X. | Deposit date: | 2020-06-07 | Release date: | 2020-08-19 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | Cryo-EM structures of intact V-ATPase from bovine brain. Nat Commun, 11, 2020
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6WM4
| Human V-ATPase in state 3 with SidK and ADP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, Renin receptor, ... | Authors: | Wang, L, Wu, H, Fu, T.M. | Deposit date: | 2020-04-20 | Release date: | 2020-11-11 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Mol.Cell, 80, 2020
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6WTD
| Monomer yeast ATP synthase Fo reconstituted in nanodisc with inhibitor of Bedaquiline bound | Descriptor: | ATP synthase protein 8, ATP synthase subunit 4, mitochondrial, ... | Authors: | Mueller, D.M, Srivastava, A.P, Symersky, J, Luo, M, Liao, M.F. | Deposit date: | 2020-05-02 | Release date: | 2020-08-26 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Bedaquiline inhibits the yeast and human mitochondrial ATP synthases. Commun Biol, 3, 2020
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6XBW
| Cryo-EM structure of V-ATPase from bovine brain, state 1 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Wang, R, Li, X. | Deposit date: | 2020-06-07 | Release date: | 2020-08-19 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Cryo-EM structures of intact V-ATPase from bovine brain. Nat Commun, 11, 2020
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6YNY
| Cryo-EM structure of Tetrahymena thermophila mitochondrial ATP synthase - F1Fo composite dimer model | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Kock Flygaard, R, Muhleip, A, Amunts, A. | Deposit date: | 2020-04-14 | Release date: | 2020-09-30 | Last modified: | 2020-11-11 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization. Nat Commun, 11, 2020
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7FDA
| CryoEM Structure of Reconstituted V-ATPase, state1 | Descriptor: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | Deposit date: | 2021-07-16 | Release date: | 2021-12-22 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation. Embo J., 2021
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7FDC
| CryoEM Structures of Reconstituted V-ATPase, state3 | Descriptor: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | Deposit date: | 2021-07-16 | Release date: | 2021-12-22 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation. Embo J., 2021
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7FDB
| CryoEM Structures of Reconstituted V-ATPase,State2 | Descriptor: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | Deposit date: | 2021-07-16 | Release date: | 2021-12-22 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation. Embo J., 2021
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