3L05
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![BU of 3l05 by Molmil](/molmil-images/mine/3l05) | Crystal structure of N-acetyl-L-ornithine transcarbamylase E92S mutant complexed with carbamyl phosphate and N-succinyl-L-norvaline | Descriptor: | N-(3-CARBOXYPROPANOYL)-L-NORVALINE, N-acetylornithine carbamoyltransferase, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER, ... | Authors: | Shi, D, Yu, X, Allewell, N.M, Tuchman, M. | Deposit date: | 2009-12-09 | Release date: | 2010-03-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase. Protein Sci., 16, 2007
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3KWW
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![BU of 3kww by Molmil](/molmil-images/mine/3kww) | Crystal structure of the 'restriction triad' mutant of HLA B*3508, beta-2-microglobulin and EBV peptide | Descriptor: | ACETIC ACID, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Archbold, J.K, Tynan, F.E, Gras, S, Rossjohn, J. | Deposit date: | 2009-12-01 | Release date: | 2010-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability Proc.Natl.Acad.Sci.USA, 2010
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3L0S
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![BU of 3l0s by Molmil](/molmil-images/mine/3l0s) | Crystal structures of Zinc, Cobalt and Iron containing Adenylate kinase from Gram-negative bacteria Desulfovibrio gigas | Descriptor: | Adenylate kinase, COBALT (II) ION, D(-)-TARTARIC ACID | Authors: | Mukhopadhyay, A, Trincao, J, Romao, M.J. | Deposit date: | 2009-12-10 | Release date: | 2010-12-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the zinc-, cobalt-, and iron-containing adenylate kinase from Desulfovibrio gigas: a novel metal-containing adenylate kinase from Gram-negative bacteria J.Biol.Inorg.Chem., 16, 2011
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3L01
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![BU of 3l01 by Molmil](/molmil-images/mine/3l01) | Crystal structure of monomeric glycogen synthase from Pyrococcus abyssi | Descriptor: | CHLORIDE ION, GLYCEROL, GlgA glycogen synthase, ... | Authors: | Diaz, A, Martinez-Pons, C, Fita, I, Ferrer, J.C, Guinovart, J.J. | Deposit date: | 2009-12-09 | Release date: | 2010-12-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Processivity and Subcellular Localization of Glycogen Synthase Depend on a Non-catalytic High Affinity Glycogen-binding Site. J.Biol.Chem., 286, 2011
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3L2H
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![BU of 3l2h by Molmil](/molmil-images/mine/3l2h) | |
3L10
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![BU of 3l10 by Molmil](/molmil-images/mine/3l10) | Structure of split monoubiquitinated PCNA with ubiquitin in position one | Descriptor: | Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen | Authors: | Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. | Deposit date: | 2009-12-10 | Release date: | 2010-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat.Struct.Mol.Biol., 17, 2010
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3L2V
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![BU of 3l2v by Molmil](/molmil-images/mine/3l2v) | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with manganese and MK0518 (Raltegravir) | Descriptor: | 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', AMMONIUM ION, ... | Authors: | Hare, S, Gupta, S.S, Cherepanov, P. | Deposit date: | 2009-12-15 | Release date: | 2010-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Retroviral intasome assembly and inhibition of DNA strand transfer Nature, 464, 2010
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3L1G
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![BU of 3l1g by Molmil](/molmil-images/mine/3l1g) | Human AlphaB crystallin | Descriptor: | Alpha-crystallin B chain, SULFATE ION | Authors: | Laganowsky, A, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2009-12-11 | Release date: | 2010-05-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci., 19, 2010
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3L4T
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![BU of 3l4t by Molmil](/molmil-images/mine/3l4t) | Crystal complex of N-terminal Human Maltase-Glucoamylase with BJ2661 | Descriptor: | (1R,2S)-1-[(1S)-1,2-dihydroxyethyl]-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-2-hydroxypropyl sulfate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Maltase-glucoamylase, ... | Authors: | Sim, L, Rose, D.R. | Deposit date: | 2009-12-21 | Release date: | 2010-02-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata. Biochemistry, 49, 2010
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3L58
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![BU of 3l58 by Molmil](/molmil-images/mine/3l58) | Structure of BACE Bound to SCH589432 | Descriptor: | Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE | Authors: | Strickland, C, Zhu, Z. | Deposit date: | 2009-12-21 | Release date: | 2010-02-16 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
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3L30
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![BU of 3l30 by Molmil](/molmil-images/mine/3l30) | Crystal structure of porcine pancreatic phospholipase A2 complexed with dihydroxyberberine | Descriptor: | 4,14-dihydro-8H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline-9,10-diol, CALCIUM ION, CHLORIDE ION, ... | Authors: | Naveen, C, Prasanth, G.K, Abhilash, J, Pradeep, M, Ponnuraj, K, Sadasivan, C, Haridas, M. | Deposit date: | 2009-12-16 | Release date: | 2010-01-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of porcine pancreatic phospholipase A2 complexed with dihydroxyberberine To be Published
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3L4X
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![BU of 3l4x by Molmil](/molmil-images/mine/3l4x) | Crystal complex of N-terminal Human Maltase-Glucoamylase with NR4-8 | Descriptor: | (1S,2R,3S,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sim, L, Rose, D.R. | Deposit date: | 2009-12-21 | Release date: | 2010-02-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata. Biochemistry, 49, 2010
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3LKR
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![BU of 3lkr by Molmil](/molmil-images/mine/3lkr) | Crystal Structure of HLA B*3501 in complex with influenza NP418 epitope from 2009 H1N1 swine origin strain | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-35 alpha chain, ... | Authors: | Gras, S, Kedzierski, L, Valkenburg, S.A, Liu, Y.C, Denholm, J, Richards, M, Rimmelzwaan, G.F, Doherty, P.C, Turner, S.J, Rossjohn, J, Kedzierska, K. | Deposit date: | 2010-01-27 | Release date: | 2010-07-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses. Proc.Natl.Acad.Sci.USA, 107, 2010
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3L5T
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![BU of 3l5t by Molmil](/molmil-images/mine/3l5t) | |
3LN7
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![BU of 3ln7 by Molmil](/molmil-images/mine/3ln7) | |
3L7D
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![BU of 3l7d by Molmil](/molmil-images/mine/3l7d) | Crystal Structure of Glycogen Phosphorylase DK5 complex | Descriptor: | 1-(2,3-dideoxy-3-fluoro-beta-D-arabino-hexopyranosyl)-4-[(phenylcarbonyl)amino]pyrimidin-2(1H)-one, Glycogen phosphorylase, muscle form | Authors: | Tsirkone, V.G, Lamprakis, C, Hayes, J.M, Skamnaki, V, Drakou, C, Zographos, S.E, Leonidas, D.D. | Deposit date: | 2009-12-28 | Release date: | 2010-10-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies. Bioorg.Med.Chem., 18, 2010
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3LOU
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![BU of 3lou by Molmil](/molmil-images/mine/3lou) | |
3L8S
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![BU of 3l8s by Molmil](/molmil-images/mine/3l8s) | Human p38 MAP Kinase in Complex with CP-547632 | Descriptor: | 3-[(4-bromo-2,6-difluorobenzyl)oxy]-5-{[(4-pyrrolidin-1-ylbutyl)carbamoyl]amino}isothiazole-4-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | Authors: | Gruetter, C, Simard, J.R, Rauh, D. | Deposit date: | 2010-01-03 | Release date: | 2010-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132, 2010
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3LPI
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![BU of 3lpi by Molmil](/molmil-images/mine/3lpi) | Structure of BACE Bound to SCH745132 | Descriptor: | Beta-secretase 1, L(+)-TARTARIC ACID, N'-{(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-[(2R)-4-(phenylsulfonyl)piperazin-2-yl]ethyl}-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide | Authors: | Strickland, C, Cumming, J. | Deposit date: | 2010-02-05 | Release date: | 2010-04-14 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20, 2010
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3L93
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![BU of 3l93 by Molmil](/molmil-images/mine/3l93) | Phosphopantetheine adenylyltransferase from Yersinia pestis. | Descriptor: | FORMIC ACID, Phosphopantetheine adenylyltransferase | Authors: | Osipiuk, J, Maltseva, N, Makowska-grzyska, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2010-01-04 | Release date: | 2010-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | X-ray crystal structure of phosphopantetheine adenylyltransferase from Yersinia pestis. To be Published
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3L9W
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![BU of 3l9w by Molmil](/molmil-images/mine/3l9w) | KefC C-terminal domain in complex with KefF and GSH | Descriptor: | ADENOSINE MONOPHOSPHATE, FLAVIN MONONUCLEOTIDE, GLUTATHIONE, ... | Authors: | Roosild, T.P. | Deposit date: | 2010-01-05 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Mechanism of ligand-gated potassium efflux in bacterial pathogens. Proc.Natl.Acad.Sci.USA, 107, 2010
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3LRE
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![BU of 3lre by Molmil](/molmil-images/mine/3lre) | |
3LC7
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![BU of 3lc7 by Molmil](/molmil-images/mine/3lc7) | Crystal Structure of apo Glyceraldehyde-3-phosphate dehydrogenase 1 (GAPDH1) from methicllin resistant Staphylococcus aureus (MRSA252) | Descriptor: | GLYCEROL, Glyceraldehyde-3-phosphate dehydrogenase 1 | Authors: | Mukherjee, S, Dutta, D, Saha, B, Das, A.K. | Deposit date: | 2010-01-10 | Release date: | 2010-08-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of glyceraldehyde-3-phosphate dehydrogenase 1 from methicillin-resistant Staphylococcus aureus MRSA252 provides novel insights into substrate binding and catalytic mechanism. J.Mol.Biol., 401, 2010
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3LCV
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![BU of 3lcv by Molmil](/molmil-images/mine/3lcv) | Crystal Structure of Antibiotic related Methyltransferase | Descriptor: | S-ADENOSYLMETHIONINE, Sisomicin-gentamicin resistance methylase Sgm | Authors: | Sivaraman, J, Husain, N. | Deposit date: | 2010-01-11 | Release date: | 2010-06-02 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases. Nucleic Acids Res., 2010
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3LD1
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![BU of 3ld1 by Molmil](/molmil-images/mine/3ld1) | Crystal Structure of IBV Nsp2a | Descriptor: | Replicase polyprotein 1a | Authors: | Xu, Y, Cong, L, Wei, L, Fu, J, Chen, C, Yang, A, Tang, H, Bartlam, M, Rao, Z. | Deposit date: | 2010-01-12 | Release date: | 2011-05-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.498 Å) | Cite: | IBV nsp2 is an endosome-associated protein and viral pathogenicity factor To be Published
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