1KV1
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![BU of 1kv1 by Molmil](/molmil-images/mine/1kv1) | p38 MAP Kinase in Complex with Inhibitor 1 | Descriptor: | 1-(5-TERT-BUTYL-2-METHYL-2H-PYRAZOL-3-YL)-3-(4-CHLORO-PHENYL)-UREA, p38 MAP kinase | Authors: | Pargellis, C, Tong, L, Churchill, L, Cirillo, P.F, Gilmore, T, Graham, A.G, Grob, P.M, Hickey, E.R, Moss, N, Pav, S, Regan, J. | Deposit date: | 2002-01-23 | Release date: | 2002-03-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat.Struct.Biol., 9, 2002
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3W8Q
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![BU of 3w8q by Molmil](/molmil-images/mine/3w8q) | Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Nakae, S, Kitamura, M, Shirai, T, Tada, T. | Deposit date: | 2013-03-20 | Release date: | 2014-03-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation. Acta Crystallogr.,Sect.F, 77, 2021
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1Y1C
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![BU of 1y1c by Molmil](/molmil-images/mine/1y1c) | Solution structure of Anemonia elastase inhibitor analogue | Descriptor: | Elastase inhibitor | Authors: | Hemmi, H, Kumazaki, T, Yoshizawa-Kumagaye, K, Nishiuchi, Y, Yoshida, T, Ohkubo, T, Kobayashi, Y. | Deposit date: | 2004-11-18 | Release date: | 2005-07-19 | Last modified: | 2021-11-10 | Method: | SOLUTION NMR | Cite: | Structural and Functional Study of an Anemonia Elastase Inhibitor, a "Nonclassical" Kazal-Type Inhibitor from Anemonia sulcata Biochemistry, 44, 2005
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1TPO
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![BU of 1tpo by Molmil](/molmil-images/mine/1tpo) | THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | Descriptor: | BETA-TRYPSIN, CALCIUM ION | Authors: | Bode, W, Walter, J, Huber, R. | Deposit date: | 1982-09-27 | Release date: | 1983-01-18 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors Acta Crystallogr.,Sect.B, 39, 1983
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1KV2
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![BU of 1kv2 by Molmil](/molmil-images/mine/1kv2) | Human p38 MAP Kinase in Complex with BIRB 796 | Descriptor: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, p38 MAP kinase | Authors: | Pargellis, C, Tong, L, Churchill, L, Cirillo, P.F, Gilmore, T, Graham, A.G, Grob, P.M, Hickey, E.R, Moss, N, Pav, S, Regan, J. | Deposit date: | 2002-01-23 | Release date: | 2002-03-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat.Struct.Biol., 9, 2002
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3HEC
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![BU of 3hec by Molmil](/molmil-images/mine/3hec) | P38 in complex with Imatinib | Descriptor: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | Authors: | Namboodiri, H.V, Karpusas, M. | Deposit date: | 2009-05-08 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Biochemistry, 49, 2010
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1KX0
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![BU of 1kx0 by Molmil](/molmil-images/mine/1kx0) | Rat mannose protein A (H189V I207V) complexed with man-a13-man | Descriptor: | CALCIUM ION, CHLORIDE ION, MANNOSE-BINDING PROTEIN A, ... | Authors: | Ng, K.K, Kolatkar, A.R, Park-Snyder, S, Feinberg, H, Clark, D.A, Drickamer, K, Weis, W.I. | Deposit date: | 2002-01-30 | Release date: | 2002-07-05 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J.Biol.Chem., 277, 2002
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1TPS
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1KVO
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![BU of 1kvo by Molmil](/molmil-images/mine/1kvo) | HUMAN PHOSPHOLIPASE A2 COMPLEXED WITH A HIGHLY POTENT SUBSTRATE ANOLOGUE | Descriptor: | 4-(S)-[(1-OXO-7-PHENYLHEPTYL)AMINO]-5-[4-(PHENYLMETHYL)PHENYLTHIO]PENTANOIC ACID, CALCIUM ION, HUMAN PHOSPHOLIPASE A2 | Authors: | Cha, S.-S, Abdel-Meguid, S.S, Oh, B.-H. | Deposit date: | 1996-07-29 | Release date: | 1997-07-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX). J.Med.Chem., 39, 1996
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1TYN
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![BU of 1tyn by Molmil](/molmil-images/mine/1tyn) | ATOMIC STRUCTURE OF THE TRYPSIN-CYCLOTHEONAMIDE A COMPLEX: LESSONS FOR THE DESIGN OF SERINE PROTEASE INHIBITORS | Descriptor: | BETA-TRYPSIN, CYCLOTHEONAMIDE A | Authors: | Lee, A.Y, Hagihara, M, Karmacharya, R, Albers, M.W, Schreiber, S.L, Clardy, J. | Deposit date: | 1994-09-19 | Release date: | 1995-01-26 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Atomic Structure of the Trypsin-Cyclotheonamide a Complex: Lessons for the Design of Serine Protease Inhibitors J.Am.Chem.Soc., 115, 1993
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1KLT
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![BU of 1klt by Molmil](/molmil-images/mine/1klt) | |
1Y09
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![BU of 1y09 by Molmil](/molmil-images/mine/1y09) | |
1TNL
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1TPP
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![BU of 1tpp by Molmil](/molmil-images/mine/1tpp) | THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | Descriptor: | (2S)-3-(4-carbamimidoylphenyl)-2-hydroxypropanoic acid, BETA-TRYPSIN, CALCIUM ION, ... | Authors: | Walter, J, Bode, W, Huber, R. | Deposit date: | 1982-09-27 | Release date: | 1983-01-18 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors Acta Crystallogr.,Sect.B, 39, 1983
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1Y0M
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![BU of 1y0m by Molmil](/molmil-images/mine/1y0m) | |
3IG7
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![BU of 3ig7 by Molmil](/molmil-images/mine/3ig7) | Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2 | Descriptor: | Cell division protein kinase 2, N-{1-[cis-3-(acetylamino)cyclobutyl]-1H-imidazol-4-yl}-2-(4-methoxyphenyl)acetamide | Authors: | Pandit, J. | Deposit date: | 2009-07-27 | Release date: | 2009-09-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease. Bioorg.Med.Chem.Lett., 19, 2009
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2EKJ
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![BU of 2ekj by Molmil](/molmil-images/mine/2ekj) | Solution structures of the fn3 domain of human collagen alpha-1(XX) chain | Descriptor: | Collagen alpha-1(XX) chain | Authors: | Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-23 | Release date: | 2007-09-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structures of the fn3 domain of human collagen alpha-1(XX) chain To be Published
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1Y4F
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![BU of 1y4f by Molmil](/molmil-images/mine/1y4f) | |
3A7F
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![BU of 3a7f by Molmil](/molmil-images/mine/3a7f) | Human MST3 kinase | Descriptor: | Serine/threonine kinase 24 (STE20 homolog, yeast) | Authors: | Ko, T.P, Jeng, W.Y, Liu, C.I, Lai, M.D, Wang, A.H.J. | Deposit date: | 2009-09-26 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structures of human MST3 kinase in complex with adenine, ADP and Mn2+. Acta Crystallogr.,Sect.D, 66, 2010
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2EM9
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![BU of 2em9 by Molmil](/molmil-images/mine/2em9) | Solution structure of the C2H2 type zinc finger (region 367-399) of human Zinc finger protein 224 | Descriptor: | ZINC ION, Zinc finger protein 224 | Authors: | Tomizawa, T, Tochio, N, Abe, H, Saito, K, Li, H, Sato, M, Koshiba, S, Kobayashi, N, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-28 | Release date: | 2007-10-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the C2H2 type zinc finger (region 367-399) of human Zinc finger protein 224 To be Published
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1KRN
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![BU of 1krn by Molmil](/molmil-images/mine/1krn) | STRUCTURE OF KRINGLE 4 AT 4C TEMPERATURE AND 1.67 ANGSTROMS RESOLUTION | Descriptor: | PLASMINOGEN, SULFATE ION | Authors: | Stec, B, Teeter, M.M, Whitlow, M, Yamano, A. | Deposit date: | 1995-06-21 | Release date: | 1997-01-11 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structure of human plasminogen kringle 4 at 1.68 a and 277 K. A possible structural role of disordered residues. Acta Crystallogr.,Sect.D, 53, 1997
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1Y4V
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1KVX
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2EMZ
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![BU of 2emz by Molmil](/molmil-images/mine/2emz) | Solution structure of the C2H2 type zinc finger (region 628-660) of human Zinc finger protein 95 homolog | Descriptor: | ZINC ION, Zinc finger protein 95 homolog | Authors: | Tochio, N, Tomizawa, T, Abe, H, Saito, K, Li, H, Sato, M, Koshiba, S, Kobayashi, N, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-28 | Release date: | 2007-10-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the C2H2 type zinc finger (region 628-660) of human Zinc finger protein 95 homolog To be Published
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2EOI
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![BU of 2eoi by Molmil](/molmil-images/mine/2eoi) | Solution structure of the C2H2 type zinc finger (region 329-359) of human Zinc finger protein 268 | Descriptor: | ZINC ION, Zinc finger protein 268 | Authors: | Tochio, N, Tomizawa, T, Abe, H, Saito, K, Li, H, Sato, M, Koshiba, S, Kobayashi, N, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-29 | Release date: | 2007-10-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the C2H2 type zinc finger (region 329-359) of human Zinc finger protein 268 To be Published
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