5HZW
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![BU of 5hzw by Molmil](/molmil-images/mine/5hzw) | Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 2, Maltose-binding periplasmic protein,Endoglin, ... | Authors: | Bokhove, M, Saito, T, Jovine, L. | Deposit date: | 2016-02-03 | Release date: | 2017-06-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (4.451 Å) | Cite: | Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1. Cell Rep, 19, 2017
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5HSU
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![BU of 5hsu by Molmil](/molmil-images/mine/5hsu) | Fluorine substituted 5-methyl-6-(2',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine | Descriptor: | 5-methyl-6-[(2,3,4-trifluorophenyl)sulfanyl]thieno[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cody, V. | Deposit date: | 2016-01-26 | Release date: | 2017-02-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines To Be Published
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4YX7
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![BU of 4yx7 by Molmil](/molmil-images/mine/4yx7) | |
3PB2
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![BU of 3pb2 by Molmil](/molmil-images/mine/3pb2) | |
4YJO
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![BU of 4yjo by Molmil](/molmil-images/mine/4yjo) | THE KINASE DOMAIN OF HUMAN SPLEEN TYROSINE (SYK) IN COMPLEX WITH GTC000222 | Descriptor: | 5-chloro-N~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-N~4~-ethyl-N~4~-(1H-indazol-4-yl)pyrimidine-2,4-diamine, GLYCEROL, Tyrosine-protein kinase SYK | Authors: | Somers, D.O, Neu, M. | Deposit date: | 2015-03-03 | Release date: | 2015-09-30 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg. Med. Chem. Lett., 21, 2011
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4FZL
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![BU of 4fzl by Molmil](/molmil-images/mine/4fzl) | High resolution structure of truncated bacteriocin syringacin M from Pseudomonas syringae pv. tomato DC3000 | Descriptor: | 1,2-ETHANEDIOL, Bacteriocin, CALCIUM ION, ... | Authors: | Roszak, A.W, Grinter, R, Cogdell, J.R, Walker, D. | Deposit date: | 2012-07-06 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | The Crystal Structure of the Lipid II-degrading Bacteriocin Syringacin M Suggests Unexpected Evolutionary Relationships between Colicin M-like Bacteriocins. J.Biol.Chem., 287, 2012
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8XDT
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![BU of 8xdt by Molmil](/molmil-images/mine/8xdt) | |
8Z8O
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![BU of 8z8o by Molmil](/molmil-images/mine/8z8o) | |
3SF6
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![BU of 3sf6 by Molmil](/molmil-images/mine/3sf6) | |
8ZFW
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![BU of 8zfw by Molmil](/molmil-images/mine/8zfw) | |
4FZN
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4ZDN
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![BU of 4zdn by Molmil](/molmil-images/mine/4zdn) | Streptomyces platensis isomigrastatin ketosynthase domain MgsF KS4 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AT-less polyketide synthase, CHLORIDE ION | Authors: | Chang, C, Li, H, Endres, M, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-04-17 | Release date: | 2015-05-13 | Last modified: | 2023-03-22 | Method: | X-RAY DIFFRACTION (2.509 Å) | Cite: | Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
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4FZM
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![BU of 4fzm by Molmil](/molmil-images/mine/4fzm) | Crystal structure of the bacteriocin syringacin M from Pseudomonas syringae pv. tomato DC3000 | Descriptor: | 1,2-ETHANEDIOL, Bacteriocin, CALCIUM ION | Authors: | Roszak, A.W, Grinter, R, Cogdell, J.R, Walker, D. | Deposit date: | 2012-07-06 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | The Crystal Structure of the Lipid II-degrading Bacteriocin Syringacin M Suggests Unexpected Evolutionary Relationships between Colicin M-like Bacteriocins. J.Biol.Chem., 287, 2012
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5HVE
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![BU of 5hve by Molmil](/molmil-images/mine/5hve) | 5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine | Descriptor: | 5-methyl-6-{[3-(trifluoromethoxy)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cody, V. | Deposit date: | 2016-01-28 | Release date: | 2017-02-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines To Be Published
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2LW1
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![BU of 2lw1 by Molmil](/molmil-images/mine/2lw1) | The C-terminal domain of the Uup protein is a DNA-binding coiled coil motif | Descriptor: | ABC transporter ATP-binding protein uup | Authors: | Carlier, L, Haase, A.S, Burgos Zepeda, M.Y, Dassa, E, Lequin, O. | Deposit date: | 2012-07-19 | Release date: | 2012-09-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The C-terminal domain of the Uup protein is a DNA-binding coiled coil motif. J.Struct.Biol., 180, 2012
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5HT4
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![BU of 5ht4 by Molmil](/molmil-images/mine/5ht4) | 6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl) | Descriptor: | 7-ethyl-6-[(3-methoxyphenyl)sulfanyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Cody, V. | Deposit date: | 2016-01-26 | Release date: | 2017-02-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines To Be Published
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5HZV
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![BU of 5hzv by Molmil](/molmil-images/mine/5hzv) | Crystal structure of the zona pellucida module of human endoglin/CD105 | Descriptor: | GLYCEROL, Maltose-binding periplasmic protein,Endoglin, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Bokhove, M, Saito, T, Jovine, L. | Deposit date: | 2016-02-03 | Release date: | 2017-06-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1. Cell Rep, 19, 2017
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1GPQ
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![BU of 1gpq by Molmil](/molmil-images/mine/1gpq) | Structure of ivy complexed with its target, HEWL | Descriptor: | INHIBITOR OF VERTEBRATE LYSOZYME, LYSOZYME C | Authors: | Abergel, C, Monchois, V, Claverie, J.-M. | Deposit date: | 2001-11-08 | Release date: | 2003-03-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and Evolution of the Ivy Protein Family, Unexpected Lysozyme Inhibitors in Gram-Negative Bacteria. Proc.Natl.Acad.Sci.USA, 104, 2007
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4ZR6
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![BU of 4zr6 by Molmil](/molmil-images/mine/4zr6) | Lymnaea Stagnalis Acetylcholine Binding Protein in Complex with 3-[(4E)-4-[(3-methylimidazol-4-yl)methylene]-2,3-dihydropyrrol-5-yl]pyridine | Descriptor: | 3-{(4E)-4-[(1-methyl-1H-imidazol-5-yl)methylidene]-3,4-dihydro-2H-pyrrol-5-yl}pyridine, Acetylcholine-binding protein | Authors: | Bobango, J, Bryant, D, Denton, T.T, Talley, T.T. | Deposit date: | 2015-05-11 | Release date: | 2016-05-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-guided design and analysis of arylidene anabaseines and myosmines To be Published
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8XDU
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![BU of 8xdu by Molmil](/molmil-images/mine/8xdu) | |
4YGO
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![BU of 4ygo by Molmil](/molmil-images/mine/4ygo) | Dodecameric structure of spermidine N-acetyltransferase from Vibrio cholerae in intermediate state | Descriptor: | CALCIUM ION, METHANOL, Spermidine n1-acetyltransferase | Authors: | Filippova, E.V, Minasov, G, Kiryukhina, O, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2015-02-26 | Release date: | 2015-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Substrate-Induced Allosteric Change in the Quaternary Structure of the Spermidine N-Acetyltransferase SpeG. J.Mol.Biol., 427, 2015
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8XDR
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![BU of 8xdr by Molmil](/molmil-images/mine/8xdr) | O-methyltransferase from Lycoris aurea complexed with Mg, SAH, and 3,4-dihydroxybenzaldehyde | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, MAGNESIUM ION, ... | Authors: | Saw, Y.Y.H, Nakashima, Y, Morita, H. | Deposit date: | 2023-12-11 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases Acs Catalysis, 2024
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8XDV
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8XDQ
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![BU of 8xdq by Molmil](/molmil-images/mine/8xdq) | O-methyltransferase from Lycoris aurea complexed with Mg and SAH | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, MAGNESIUM ION, ... | Authors: | Saw, Y.Y.H, Nakashima, Y, Morita, H. | Deposit date: | 2023-12-11 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases Acs Catalysis, 2024
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8XDO
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![BU of 8xdo by Molmil](/molmil-images/mine/8xdo) | |