5N2G
 
 | | Structure of the E9 DNA polymerase from vaccinia virus in complex with manganese | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Tarbouriech, N, Burmeister, W.P, Iseni, F. | | Deposit date: | 2017-02-07 | | Release date: | 2017-11-29 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding.
Nat Commun, 8, 2017
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2MOW
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1FQZ
 | | NMR VALIDATED MODEL OF DOMAIN IIID OF HEPATITIS C VIRUS INTERNAL RIBOSOME ENTRY SITE | | Descriptor: | HEPATITIS C VIRUS IRES DOMAIN IIID | | Authors: | Klinck, R, Westhof, E, Walker, S, Afshar, M, Collier, A, Aboul-ela, F. | | Deposit date: | 2000-09-07 | | Release date: | 2001-01-17 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | A potential RNA drug target in the hepatitis C virus internal ribosomal entry site.
RNA, 6, 2000
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2CLX
 | | 4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects | | Descriptor: | 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, CELL DIVISION PROTEIN KINASE 2 | | Authors: | Krystof, V, Cankar, P, Frysova, I, Slouka, J, Kontopidis, G, Dzubak, P, Hajduch, M, Deazevedo, W.F, Paprskarova, M, Orsag, M, Rolcik, J, Latr, A, Fischer, P.M, Strnad, M. | | Deposit date: | 2006-05-02 | | Release date: | 2006-11-01 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | 4-Arylazo-3,5-Diamino-1H-Pyrazole Cdk Inhibitors: Sar Study, Crystal Structure in Complex with Cdk2, Selectivity, and Cellular Effects
J.Med.Chem., 49, 2006
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8HPP
 | | Crystal structure of human INTS3 with SAGE1 | | Descriptor: | Integrator complex subunit 3, Sarcoma antigen 1 | | Authors: | Deng, W, Wu, J, Lei, M. | | Deposit date: | 2022-12-12 | | Release date: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Cancer-testis antigen SAGE1 is a pan-cancer master regulator of RNA polymerase II
To Be Published
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5TYX
 | | DNA Polymerase Mu Product Complex, Mn2+ (15 min) | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... | | Authors: | Jamsen, J.A, Wilson, S.H. | | Deposit date: | 2016-11-21 | | Release date: | 2017-08-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.948 Å) | | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.
Nat Commun, 8, 2017
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5TYY
 | | DNA Polymerase Mu Product Complex, Mn2+ (60 min) | | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Jamsen, J.A, Wilson, S.H. | | Deposit date: | 2016-11-21 | | Release date: | 2017-08-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.931 Å) | | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.
Nat Commun, 8, 2017
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5TYV
 | | DNA Polymerase Mu Reactant Complex, Mn2+ (7.5 min) | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... | | Authors: | Jamsen, J.A, Wilson, S.H. | | Deposit date: | 2016-11-21 | | Release date: | 2017-08-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.
Nat Commun, 8, 2017
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5TYW
 | | DNA Polymerase Mu Reactant Complex, Mn2+ (10 min) | | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Jamsen, J.A, Wilson, S.H. | | Deposit date: | 2016-11-21 | | Release date: | 2017-08-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.
Nat Commun, 8, 2017
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5TYZ
 | | DNA Polymerase Mu Product Complex, Mn2+ (960 min) | | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Jamsen, J.A, Wilson, S.H. | | Deposit date: | 2016-11-21 | | Release date: | 2017-08-30 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.977 Å) | | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.
Nat Commun, 8, 2017
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5TYU
 | | DNA Polymerase Mu Reactant Complex, Mn2+ (4 min) | | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Jamsen, J.A, Wilson, S.H. | | Deposit date: | 2016-11-21 | | Release date: | 2017-08-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.048 Å) | | Cite: | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.
Nat Commun, 8, 2017
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4BJI
 | | Sfc1-DBD | | Descriptor: | TRANSCRIPTION FACTOR TAU SUBUNIT SFC1 | | Authors: | Taylor, N.M.I, Baudin, F, von Scheven, G, Muller, C.W. | | Deposit date: | 2013-04-18 | | Release date: | 2013-07-31 | | Last modified: | 2013-11-06 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | RNA Polymerase III-Specific General Transcription Factor Iiic Contains a Heterodimer Resembling Tfiif RAP30/RAP74.
Nucleic Acids Res., 41, 2013
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2KY6
 | | Structure of ARC92VBD/MED25ACID | | Descriptor: | Mediator of RNA polymerase II transcription subunit 25 | | Authors: | Milbradt, A.G, Sun, Z.J, Selenko, P, Takeuchi, K, Naar, A.M, Wagner, G. | | Deposit date: | 2010-05-14 | | Release date: | 2011-03-09 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structure of the VP16 transactivator target in the Mediator.
Nat.Struct.Mol.Biol., 18, 2011
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1XB4
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2L23
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2L3T
 | | Solution structure of tandem SH2 domain from Spt6 | | Descriptor: | Transcription elongation factor SPT6 | | Authors: | Liu, J, Zhang, J, Wu, J, Shi, Y. | | Deposit date: | 2010-09-22 | | Release date: | 2011-06-15 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain
To be Published
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4D7X
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4W5R
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4W5Q
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7OM7
 | | Thosea asigna virus RdRP domain in complex with RNA and nucleotide UMPNPP | | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | | Authors: | Ferrero, D.S, Falqui, M, Verdaguer, N. | | Deposit date: | 2021-05-21 | | Release date: | 2021-07-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Snapshots of a Non-Canonical RdRP in Action.
Viruses, 13, 2021
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4W5T
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4W5N
 | | The Crystal Structure of Human Argonaute2 Bound to a Defined Guide RNA | | Descriptor: | MAGNESIUM ION, PHENOL, Protein argonaute-2, ... | | Authors: | Schirle, N.T, Sheu-Gruttadauria, J, MacRae, I.J. | | Deposit date: | 2014-08-18 | | Release date: | 2014-11-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
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4W5O
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4Z4F
 | | Human Argonaute2 Bound to t1-DAP Target RNA | | Descriptor: | MAGNESIUM ION, PHENOL, Protein argonaute-2, ... | | Authors: | Schirle, N.T, MacRae, I.J. | | Deposit date: | 2015-04-02 | | Release date: | 2015-09-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.
Elife, 4, 2015
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4Z4D
 | | Human Argonaute2 Bound to t1-G Target RNA | | Descriptor: | ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ... | | Authors: | Schirle, N.T, MacRae, I.J. | | Deposit date: | 2015-04-02 | | Release date: | 2015-09-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.
Elife, 4, 2015
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