PDB: 1345 resultsInfo pagesStatus searchChemie searchBIRD

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5C4G	Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with the inhibitor BQR695 in complex with GDP loaded Rab11 Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, N~2~-[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]-N-methylglycinamide, ... Authors: Burke, J.E, Fowler, M.L. Deposit date: 2015-06-18 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11. Protein Sci., 25, 2016
5CLL	Truncated Ran wild type in complex with GDP-BeF and RanBD1 Descriptor: BERYLLIUM TRIFLUORIDE ION, E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, ... Authors: Vetter, I.R, Brucker, S. Deposit date: 2015-07-16 Release date: 2015-09-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy. J.Biol.Chem., 290, 2015
5CM8	Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral Descriptor: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a Authors: Popovic, M, Schouten, A, Rehmann, H. Deposit date: 2015-07-16 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity. J.Struct.Biol., 193, 2016
5CM9	Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral Descriptor: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a Authors: Popovic, M, Schouten, A, Rehmann, H. Deposit date: 2015-07-16 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity. J.Struct.Biol., 193, 2016
3LW8	Shigella IpgB2 in complex with human RhoA, GDP and Mg2+ (complex A) Descriptor: GUANOSINE-5'-DIPHOSPHATE, IpgB2, MAGNESIUM ION, ... Authors: Klink, B.U, Barden, S, Heidler, T.V, Borchers, C, Ladwein, M, Stradal, T.E.B, Rottner, K, Heinz, D.W. Deposit date: 2010-02-23 Release date: 2010-03-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure of Shigella IPGB2 in complex with human RhoA: Implications for the mechanism of bacterial GEF-mimicry J.Biol.Chem., 285, 2010
2REX	Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase Descriptor: CALCIUM ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Tong, Y, Tempel, W, Shen, L, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2007-09-27 Release date: 2007-11-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase. To be Published
2RGN	Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... Authors: Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. Deposit date: 2007-10-04 Release date: 2008-01-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318, 2007
5DHF	Crystal Structure of hRio2 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.285 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIS	Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214 Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Monecke, T, Port, S.A, Dickmanns, A, Kehlenbach, R.H, Ficner, R. Deposit date: 2015-09-01 Release date: 2015-11-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Rep, 13, 2015
2BOV	Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MONO-ADP-RIBOSYLTRANSFERASE C3, ... Authors: Holbourn, K.P, Sutton, J.M, Evans, H.R, Shone, C.C, Acharya, K.R. Deposit date: 2005-04-14 Release date: 2005-04-15 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Molecular Recognition of an Adp-Ribosylating Clostridium Botulinum C3 Exoenzyme by Rala Gtpase Proc.Natl.Acad.Sci.USA, 102, 2005
2D7C	Crystal structure of human Rab11 in complex with FIP3 Rab-binding domain Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Shiba, T, Koga, H, Shin, H.W, Kawasaki, M, Kato, R, Nakayama, K, Wakatsuki, S. Deposit date: 2005-11-16 Release date: 2006-09-26 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. Proc.Natl.Acad.Sci.Usa, 103, 2006
3LXR	Shigella IpgB2 in complex with human RhoA and GDP (complex C) Descriptor: GUANOSINE-5'-DIPHOSPHATE, IpgB2, SULFATE ION, ... Authors: Klink, B.U, Barden, S, Heidler, T.V, Borchers, C, Ladwein, M, Stradal, T.E.B, Rottner, K, Heinz, D.W. Deposit date: 2010-02-25 Release date: 2010-03-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Structure of Shigella IPGB2 in complex with human RhoA: Implications for the mechanism of bacterial GEF-mimicry J.Biol.Chem., 285, 2010
3LWN	Shigella IpgB2 in complex with human RhoA, GDP and Mg2+ (complex B) Descriptor: GUANOSINE-5'-DIPHOSPHATE, IpgB2, MAGNESIUM ION, ... Authors: Klink, B.U, Barden, S, Heidler, T.V, Borchers, C, Ladwein, M, Stradal, T.E.B, Rottner, K, Heinz, D.W. Deposit date: 2010-02-24 Release date: 2010-03-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structure of Shigella IPGB2 in complex with human RhoA: Implications for the mechanism of bacterial GEF-mimicry J.Biol.Chem., 285, 2010
1NVX	Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. Deposit date: 2003-02-04 Release date: 2003-04-01 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.), 112, 2003
1NVW	Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Descriptor: MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. Deposit date: 2003-02-04 Release date: 2003-04-01 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.), 112, 2003
2BKU	Kap95p:RanGTP complex Descriptor: GTP-BINDING NUCLEAR PROTEIN RAN, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN BETA-1 SUBUNIT, ... Authors: Lee, S.J, Matsuura, Y, Liu, S.M, Stewart, M. Deposit date: 2005-02-21 Release date: 2005-05-04 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural Basis for Nuclear Import Complex Dissociation by Rangtp Nature, 435, 2005
3MSX	Crystal structure of RhoA.GDP.MgF3 in complex with GAP domain of ArhGAP20 Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 20, ... Authors: Utepbergenov, D, Cooper, D.R, Derewenda, U, Derewenda, Z.S. Deposit date: 2010-04-29 Release date: 2011-03-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Mechanism of molecular specificity of RhoGAP domains towards small GTPases of RhoA family. To be Published
3JZA	Crystal structure of human Rab1b in complex with the GEF domain of DrrA/SidM from Legionella pneumophila Descriptor: PHOSPHATE ION, Ras-related protein Rab-1B, Uncharacterized protein DrrA Authors: Schoebel, S, Oesterlin, L.K, Blankenfeldt, W, Goody, R.S, Itzen, A. Deposit date: 2009-09-23 Release date: 2010-01-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity. Mol.Cell, 36, 2009
2C5L	Structure of PLC epsilon Ras association domain with hRas Descriptor: GLYCEROL, GTPASE HRAS, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Roe, S.M, Bunney, T.D, Katan, M, Pearl, L.H. Deposit date: 2005-10-27 Release date: 2006-02-20 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon Mol.Cell, 21, 2006
5DHA	Crystal Structure of CPEB4 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (CPEB4 NES reverse mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIF	Crystal Structure of CPEB4 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Cytoplasmic polyadenylation element-binding protein 4, Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.092 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DI9	Crystal Structure of hRio2 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Engineered Nuclear Export Signal Peptide (hRio2 NES reverse mutant), Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DLQ	Crystal structure of RanGTP-Exportin 4-eIF5A complex Descriptor: Eukaryotic translation initiation factor 5A-1, Exportin-4, GTP-binding nuclear protein Ran, ... Authors: Aksu, M, Trakhanov, S, Gorlich, D. Deposit date: 2015-09-07 Release date: 2016-06-22 Last modified: 2016-06-29 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nat Commun, 7, 2016
3M1I	Crystal structure of yeast CRM1 (Xpo1p) in complex with yeast RanBP1 (Yrb1p) and yeast RanGTP (Gsp1pGTP) Descriptor: Exportin-1, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Koyama, M, Matsuura, Y. Deposit date: 2010-03-05 Release date: 2010-06-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1 Embo J., 29, 2010
1NVU	Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. Deposit date: 2003-02-04 Release date: 2003-04-01 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.), 112, 2003

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