5IYC
 
 | | Human core-PIC in the initial transcribing state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IY7
 | | Human holo-PIC in the open state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (8.6 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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8WAS
 | | Structure of transcribing complex 9 (TC9), the initially transcribing complex with Pol II positioned 9nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-08 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (6.13 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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8WAP
 | | Structure of transcribing complex 6 (TC6), the initially transcribing complex with Pol II positioned 6nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-08 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (5.85 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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8WAN
 | | Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II positioned 4nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-07 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (6.07 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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8WAO
 | | Structure of transcribing complex 5 (TC5), the initially transcribing complex with Pol II positioned 5nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-07 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (6.4 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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8WAL
 | | Structure of transcribing complex 3 (TC3), the initially transcribing complex with Pol II positioned 3nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-07 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (8.52 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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8WAQ
 | | Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II positioned 7nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-08 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (6.29 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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8WAK
 | | Structure of transcribing complex 2 (TC2), the initially transcribing complex with Pol II positioned 2nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-07 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (5.47 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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5IYA
 | | Human core-PIC in the closed state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (5.4 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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9K3V
 | | Human RNA Polymerase III de novo transcribing complex 4 (TC4) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (96-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-20 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K36
 | | Human RNA Polymerase III de novo transcribing complex 12 (TC12) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (54-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9LXO
 | | Human RNA Polymerase III de novo transcribing complex 6 (TC6)(without 3'dATP) | | Descriptor: | DNA (127-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2025-02-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K39
 | | Human RNA Polymerase III de novo transcribing complex 8 (TC8) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (50-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K2G
 | | Human RNA Polymerase III de novo transcribing complex 13 (TC13) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (104-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-17 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K3U
 | | Human RNA Polymerase III de novo transcribing complex 5 (TC5) | | Descriptor: | DNA (97-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-20 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K38
 | | Human RNA Polymerase III de novo transcribing complex 6 (TC6) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (51-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K3B
 | | Human RNA Polymerase III de novo transcribing complex 10 overall (TC10-overall) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (102-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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6CNB
 | | Yeast RNA polymerase III initial transcribing complex | | Descriptor: | DNA (71-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Han, Y, He, Y. | | Deposit date: | 2018-03-08 | | Release date: | 2018-08-22 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
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6CND
 | | Yeast RNA polymerase III natural open complex (nOC) | | Descriptor: | DNA (71-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Han, Y, He, Y. | | Deposit date: | 2018-03-08 | | Release date: | 2018-08-22 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
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7EDX
 | | p53-bound TFIID-based core PIC on HDM2 promoter | | Descriptor: | DNA (84-mer), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | | Deposit date: | 2021-03-17 | | Release date: | 2021-05-05 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7EGB
 | | TFIID-based holo PIC on SCP promoter | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7EG7
 | | TFIID-based core PIC on SCP promoter | | Descriptor: | DNA (79-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7EG9
 | | TFIID-based intermediate PIC on SCP promoter | | Descriptor: | DNA (79-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Qi, Y, Wang, X, Wu, Z, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7EGA
 | | TFIID-based intermediate PIC on PUMA promoter | | Descriptor: | DNA (85-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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