8ZD1
 
 | | Cryo-EM structure of the xGPR4-Gs complex in pH6.2 | | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rong, N.K, Wen, X, Yang, F, Sun, J.P. | | Deposit date: | 2024-04-30 | | Release date: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.
Cell, 188, 2025
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8ZF6
 | | Cryo-EM structure of the xGPR4-Gs complex in pH6.7 | | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rong, N.K, Wen, X, Yang, F, Sun, J.P. | | Deposit date: | 2024-05-07 | | Release date: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.
Cell, 188, 2025
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8ZJG
 | | Cryo-EM structure of human CMKLR1-Gi complex bound to chemerin | | Descriptor: | CHOLESTEROL, Chemerin-like receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Liu, A.J, Liu, Y.Z, Ye, R.D. | | Deposit date: | 2024-05-14 | | Release date: | 2025-01-22 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Structural basis for full-length chemerin recognition and signaling through chemerin receptor 1.
Commun Biol, 7, 2024
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8ZFZ
 | | cryo-EM structure of Gs-coupled zebrafish GPR4 at pH 6.5 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Ma, Y, Tang, M, Ru, H, Song, G. | | Deposit date: | 2024-05-08 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structure of an activated GPR4-Gs signaling complex.
Nat Commun, 16, 2025
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8ZDC
 | | Cryo-EM structure of the human ubiquitylated pre-40S ribosome with RIOK3 | | Descriptor: | 18S rRNA, Pre-rRNA-processing protein TSR1 homolog, Protein LTV1 homolog, ... | | Authors: | Huang, Z, Wang, M, Li, Y, Beckmann, R, Cheng, J. | | Deposit date: | 2024-05-01 | | Release date: | 2025-02-12 | | Last modified: | 2025-03-12 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | RIOK3 mediates the degradation of 40S ribosomes.
Mol.Cell, 85, 2025
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8WST
 | | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 2 with MCH | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha-1, ... | | Authors: | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | | Deposit date: | 2023-10-17 | | Release date: | 2024-06-19 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors.
Cell Discov, 10, 2024
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8WXQ
 | | Structure of WDR5 in complex with WIN motif containing MBD3C | | Descriptor: | GLY-ALA-ALA-ARG-CYS-ARG-VAL-PHE-SER-PRO, WD repeat-containing protein 5 | | Authors: | Xu, L, Yang, Y. | | Deposit date: | 2023-10-30 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural studies of WDR5 in complex with MBD3C WIN motif reveal a unique binding mode.
J.Biol.Chem., 300, 2024
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8X8L
 | | Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex | | Descriptor: | Cortistatin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Xu, H.E, You, C, Zhao, L, Li, J. | | Deposit date: | 2023-11-27 | | Release date: | 2024-06-12 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8WXU
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8WZ2
 | | Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex | | Descriptor: | G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Jin, S, Li, X, Xu, Y, Guo, S, Wu, C, Zhang, H, Yuan, Q, Xu, H.E, Xie, X, Jiang, Y. | | Deposit date: | 2023-11-01 | | Release date: | 2024-06-19 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor.
Cell Discov, 10, 2024
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8WXR
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8WXV
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8WXX
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8X8N
 | | Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha, ... | | Authors: | Xu, H.E, You, C, Zhao, L, Li, J. | | Deposit date: | 2023-11-27 | | Release date: | 2024-06-12 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9B0Q
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9B0G
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9B0S
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9B0R
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3TCH
 | | Crystal structure of E. coli OppA in an open conformation | | Descriptor: | Periplasmic oligopeptide-binding protein | | Authors: | Klepsch, M.M, Kovermann, M, Low, C, Balbach, J, de Gier, J.W, Slotboom, D.J, Berntsson, R.P.-A. | | Deposit date: | 2011-08-09 | | Release date: | 2011-10-12 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Escherichia coli peptide binding protein OppA has a preference for positively charged peptides.
J.Mol.Biol., 414, 2011
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9B0H
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9B0F
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8ZTV
 | | 70S ribosome arrested by PepNL with RF2 | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Ando, Y, Kobo, A, Nureki, O, Taguchi, H, Itoh, Y, Chadani, Y. | | Deposit date: | 2024-06-07 | | Release date: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | A mini-hairpin shaped nascent peptide blocks translation termination by a distinct mechanism.
Nat Commun, 16, 2025
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8ZTU
 | | 70S ribosome arrested by PepNL | | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | | Authors: | Ando, Y, Kobo, A, Nureki, O, Taguchi, H, Itoh, Y, Chadani, Y. | | Deposit date: | 2024-06-07 | | Release date: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | A mini-hairpin shaped nascent peptide blocks translation termination by a distinct mechanism.
Nat Commun, 16, 2025
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9B0P
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9AS2
 | | Global reconstruction of 5-HT2AR bound to DMT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) | | Descriptor: | 2-(1H-indol-3-yl)-N,N-dimethylethan-1-amine, 5-hydroxytryptamine receptor 2A, G subunit q (Gi2-mini-Gq chimeric), ... | | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | | Deposit date: | 2024-02-24 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | The structural diversity of psychedelic drug actions revealed.
Nat Commun, 16, 2025
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