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1WVM	Crystal Structure of Psychrophilic Subtilisin-like Serine Protease APA1 from Antarctic Psychrotroph Pseudoaleromonas sp. AS-11, Complexed with Inhibitor Chymostatin Descriptor: CALCIUM ION, CHYMOSTATIN, MAGNESIUM ION, ... Authors: Dong, D, Watanabe, K. Deposit date: 2004-12-16 Release date: 2006-03-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of Psychrophilic Subtilisin-like Serine Protease from Antarctic Psychrotroph Pseudoalteromonas sp. AS-11 at 0.16 nm resolution To be Published
1WMD	Crystal Structure of alkaline serine protease KP-43 from Bacillus sp. KSM-KP43 (1.30 angstrom, 100 K) Descriptor: 1,4-DIETHYLENE DIOXIDE, CALCIUM ION, GLYCEROL, ... Authors: Nonaka, T, Fujihashi, M, Kita, A, Saeki, K, Ito, S, Horikoshi, K, Miki, K. Deposit date: 2004-07-08 Release date: 2004-09-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The Crystal Structure of an Oxidatively Stable Subtilisin-like Alkaline Serine Protease, KP-43, with a C-terminal {beta}-Barrel Domain J.Biol.Chem., 279, 2004
5SIC	MOLECULAR RECOGNITION AT THE ACTIVE SITE OF SUBTILISIN BPN': CRYSTALLOGRAPHIC STUDIES USING GENETICALLY ENGINEERED PROTEINACEOUS INHIBITOR SSI (STREPTOMYCES SUBTILISIN INHIBITOR) Descriptor: CALCIUM ION, SUBTILISIN BPN', SUBTILISIN INHIBITOR (SSI) Authors: Mitsui, Y, Takeuchi, Y, Nakamura, K.T. Deposit date: 1991-11-18 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Molecular recognition at the active site of subtilisin BPN': crystallographic studies using genetically engineered proteinaceous inhibitor SSI (Streptomyces subtilisin inhibitor). Protein Eng., 4, 1991
3M0C	The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor Descriptor: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9 Authors: Spraggon, G, Hampton, E.N. Deposit date: 2010-03-02 Release date: 2011-03-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (7.01 Å) Cite: The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor To be Published
4OV6	Crystal structure of PCSK9(53-451) with Adnectin Descriptor: 1,2-ETHANEDIOL, Adnectin, Proprotein convertase subtilisin/kexin type 9, ... Authors: Khan, J.A. Deposit date: 2014-02-20 Release date: 2014-07-02 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering. J.Pharmacol.Exp.Ther., 350, 2014
3P5C	The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation Descriptor: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9 Authors: Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A. Deposit date: 2010-10-08 Release date: 2011-10-26 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (4.2 Å) Cite: Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Embo Rep., 12, 2011
3P5B	The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation Descriptor: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9 Authors: Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A. Deposit date: 2010-10-08 Release date: 2011-10-26 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Embo Rep., 12, 2011
3QTL	Structural Basis for Dual-inhibition Mechanism of a Non-classical Kazal-type Serine Protease Inhibitor from Horseshoe Crab in Complex with Subtilisin Descriptor: Kazal-type serine protease inhibitor SPI-1, Subtilisin-like serin protease Authors: Shenoy, R.T, Sivaraman, J. Deposit date: 2011-02-23 Release date: 2011-06-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin. Plos One, 6, 2011
1R0R	1.1 Angstrom Resolution Structure of the Complex Between the Protein Inhibitor, OMTKY3, and the Serine Protease, Subtilisin Carlsberg Descriptor: CALCIUM ION, Ovomucoid, subtilisin carlsberg Authors: Horn, J.R, Ramaswamy, S, Murphy, K.P. Deposit date: 2003-09-22 Release date: 2003-11-11 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Structure and energetics of protein-protein interactions: the role of conformational heterogeneity in OMTKY3 binding to serine proteases J.Mol.Biol., 331, 2003
1YU6	Crystal Structure of the Subtilisin Carlsberg:OMTKY3 Complex Descriptor: CALCIUM ION, Ovomucoid, Subtilisin Carlsberg Authors: Maynes, J.T, Cherney, M.M, Qasim, M.A, Laskowski Jr, M, James, M.N.G. Deposit date: 2005-02-11 Release date: 2005-05-03 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations. Acta Crystallogr.,Sect.D, 61, 2005

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