3BJ7
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1U0V
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![BU of 1u0v by Molmil](/molmil-images/mine/1u0v) | An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization of Specificity of Type III Polyketide Synthases: 18xCHS structure | Descriptor: | Chalcone synthase 2 | Authors: | Austin, M.B, Bowman, M.E, Ferrer, J.-L, Schroder, J, Noel, J.P. | Deposit date: | 2004-07-14 | Release date: | 2004-10-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases Chem.Biol., 11, 2004
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3B1Q
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![BU of 3b1q by Molmil](/molmil-images/mine/3b1q) | Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in complex with inosine | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ACETATE ION, INOSINE, ... | Authors: | Yasutake, Y, Ota, H, Hino, E, Sakasegawa, S, Tamura, T. | Deposit date: | 2011-07-05 | Release date: | 2011-11-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of Burkholderia thailandensis nucleoside kinase: implications for the catalytic mechanism and nucleoside selectivity Acta Crystallogr.,Sect.D, 67, 2011
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4JAQ
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![BU of 4jaq by Molmil](/molmil-images/mine/4jaq) | Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones | Descriptor: | 3,5-dioxoicosanoic acid, Alpha-pyrone synthesis polyketide synthase-like Pks11, COENZYME A, ... | Authors: | Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2013-02-19 | Release date: | 2013-04-24 | Last modified: | 2013-11-27 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. J.Biol.Chem., 288, 2013
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5ZHE
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![BU of 5zhe by Molmil](/molmil-images/mine/5zhe) | STRUCTURE OF E. COLI UNDECAPRENYL DIPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-981 | Descriptor: | 2-hydroxy-6-(tetradecyloxy)benzoic acid, Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | Authors: | Gao, J, Liu, W.D, Zheng, Y.Y, Ko, T.P, Chen, C.C, Guo, R.T. | Deposit date: | 2018-03-13 | Release date: | 2019-03-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis. J.Med.Chem., 62, 2019
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1I21
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![BU of 1i21 by Molmil](/molmil-images/mine/1i21) | CRYSTAL STRUCTURE OF YEAST GNA1 | Descriptor: | GLUCOSAMINE-PHOSPHATE N-ACETYLTRANSFERASE | Authors: | Peneff, C, Mengin-Lecreulx, D, Bourne, Y. | Deposit date: | 2001-02-05 | Release date: | 2001-05-16 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase. J.Biol.Chem., 276, 2001
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1I89
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![BU of 1i89 by Molmil](/molmil-images/mine/1i89) | Chalcone synthase (G256L) | Descriptor: | CHALCONE SYNTHASE 2 | Authors: | Jez, J.M, Bowman, M.E, Noel, J.P. | Deposit date: | 2001-03-12 | Release date: | 2001-12-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure-guided programming of polyketide chain-length determination in chalcone synthase. Biochemistry, 40, 2001
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4JD3
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6PRC
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![BU of 6prc by Molmil](/molmil-images/mine/6prc) | PHOTOSYNTHETIC REACTION CENTER FROM RHODOPSEUDOMONAS VIRIDIS (DG-420314 (TRIAZINE) COMPLEX) | Descriptor: | 15-cis-1,2-dihydroneurosporene, 2-CHLORO-4-ETHYLAMINO-6-(S(-)-2'-CYANO-4-BUTYLAMINO)-1,3,5-TRIAZINE, BACTERIOCHLOROPHYLL B, ... | Authors: | Lancaster, C.R.D, Michel, H. | Deposit date: | 1997-07-31 | Release date: | 1999-04-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Refined crystal structures of reaction centres from Rhodopseudomonas viridis in complexes with the herbicide atrazine and two chiral atrazine derivatives also lead to a new model of the bound carotenoid. J.Mol.Biol., 286, 1999
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5ZJV
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![BU of 5zjv by Molmil](/molmil-images/mine/5zjv) | Crystal structure of the catalytic domain of MCR-1 (cMCR-1) in complex with xylose | Descriptor: | Probable phosphatidylethanolamine transferase Mcr-1, ZINC ION, beta-L-xylopyranose | Authors: | Liu, Z.X, Han, Z, Yu, X.L, Wen, G, Zeng, C. | Deposit date: | 2018-03-22 | Release date: | 2018-04-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal Structure of the Catalytic Domain of MCR-1 (cMCR-1) in Complex with d-Xylose Crystals, 8, 2018
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4NFJ
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![BU of 4nfj by Molmil](/molmil-images/mine/4nfj) | Crystal structure of human FPPS in complex with magnesium, JDS05120, and sulfate | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ... | Authors: | Park, J, De Schutter, J.W, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2013-10-31 | Release date: | 2014-12-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. PLoS ONE, 12, 2017
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1I8B
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![BU of 1i8b by Molmil](/molmil-images/mine/1i8b) | Chalcone synthase (G256F) | Descriptor: | CHALCONE SYNTHASE 2 | Authors: | Jez, J.M, Bowman, M.E, Noel, J.P. | Deposit date: | 2001-03-12 | Release date: | 2001-12-12 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-guided programming of polyketide chain-length determination in chalcone synthase. Biochemistry, 40, 2001
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6C9N
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1I58
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![BU of 1i58 by Molmil](/molmil-images/mine/1i58) | STRUCTURE OF THE HISTIDINE KINASE CHEA ATP-BINDING DOMAIN IN COMPLEX WITH ATP ANALOG ADPCP AND MAGNESIUM | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CHEMOTAXIS PROTEIN CHEA, ... | Authors: | Bilwes, A.M, Quezada, C.M, Croal, L.R, Crane, B.R, Simon, M.I. | Deposit date: | 2001-02-26 | Release date: | 2001-08-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Nucleotide binding by the histidine kinase CheA. Nat.Struct.Biol., 8, 2001
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4JB6
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![BU of 4jb6 by Molmil](/molmil-images/mine/4jb6) | Structure of Pseudomonas aeruginosa FabF mutant C164Q | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase 2, POTASSIUM ION | Authors: | Baum, B, Lecker, L. | Deposit date: | 2013-02-19 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of Pseudomonas aeruginosa beta-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form. Acta Crystallogr F Struct Biol Commun, 71, 2015
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6BJM
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![BU of 6bjm by Molmil](/molmil-images/mine/6bjm) | Human ABO(H) blood group glycosyltransferase GTB R188K mutant | Descriptor: | ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase), ... | Authors: | Gagnon, S.M.L, Legg, M.S.G, Evans, S.V. | Deposit date: | 2017-11-06 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases. Glycobiology, 28, 2018
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4JEJ
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![BU of 4jej by Molmil](/molmil-images/mine/4jej) | GGGPS from Flavobacterium johnsoniae | Descriptor: | Geranylgeranylglyceryl phosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Peterhoff, D, Beer, B, Rajendran, C, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P. | Deposit date: | 2013-02-27 | Release date: | 2014-06-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization. Mol.Microbiol., 92, 2014
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5UHT
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![BU of 5uht by Molmil](/molmil-images/mine/5uht) | Structure of the Thermotoga maritima HK853-BeF3-RR468 complex at pH 5.0 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Liu, Y, Rose, J, Jiang, L, Zhou, P. | Deposit date: | 2017-01-12 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases. Nat Commun, 8, 2017
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1U0M
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![BU of 1u0m by Molmil](/molmil-images/mine/1u0m) | Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates | Descriptor: | GLYCEROL, POLYETHYLENE GLYCOL (N=34), putative polyketide synthase | Authors: | Austin, M.B, Izumikawa, M, Bowman, M.E, Udwary, D.W, Ferrer, J.L, Moore, B.S, Noel, J.P. | Deposit date: | 2004-07-13 | Release date: | 2004-09-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates J.Biol.Chem., 279, 2004
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5TT4
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![BU of 5tt4 by Molmil](/molmil-images/mine/5tt4) | Determining the Molecular Basis For Starter Unit Selection During Daunorubicin Biosynthesis | Descriptor: | Daunorubicin-doxorubicin polyketide synthase | Authors: | Jackson, D.R, Valentic, T.R, Patel, A, Tsai, S.C, Mohammed, L, Vasilakis, K, Wattana-amorn, P, Long, P.F, Crump, M.P, Crosby, J. | Deposit date: | 2016-11-01 | Release date: | 2016-11-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Determining the Molecular Basis For Starter Unit Selection During Daunorubicin Biosynthesis To Be Published
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4JS2
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![BU of 4js2 by Molmil](/molmil-images/mine/4js2) | Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP | Descriptor: | Beta-galactoside alpha-2,6-sialyltransferase 1, CYTIDINE-5'-MONOPHOSPHATE, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Kuhn, B, Benz, J, Greif, M, Engel, A.M, Sobek, H, Rudolph, M.G. | Deposit date: | 2013-03-22 | Release date: | 2013-07-31 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans. Acta Crystallogr.,Sect.D, 69, 2013
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4JH5
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![BU of 4jh5 by Molmil](/molmil-images/mine/4jh5) | Crystal Structure of FosB from Bacillus cereus with Cobalt and Fosfomycin | Descriptor: | COBALT (II) ION, FOSFOMYCIN, MAGNESIUM ION, ... | Authors: | Thompson, M.K, Harp, J, Keithly, M.E, Jagessar, K, Cook, P.D, Armstrong, R.N. | Deposit date: | 2013-03-04 | Release date: | 2013-10-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structural and Chemical Aspects of Resistance to the Antibiotic Fosfomycin Conferred by FosB from Bacillus cereus. Biochemistry, 52, 2013
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4NKF
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![BU of 4nkf by Molmil](/molmil-images/mine/4nkf) | The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Farnesyl pyrophosphate synthase, ... | Authors: | Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E. | Deposit date: | 2013-11-12 | Release date: | 2014-11-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates To be Published
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1KRU
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4J09
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![BU of 4j09 by Molmil](/molmil-images/mine/4j09) | Crystal Structure of LpxA bound to RJPXD33 | Descriptor: | 1,2-ETHANEDIOL, Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, DIMETHYL SULFOXIDE, ... | Authors: | Jenkins, R.J, Meagher, J.L, Stuckey, J.A, Dotson, G.D. | Deposit date: | 2013-01-30 | Release date: | 2014-04-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for the Recognition of Peptide RJPXD33 by Acyltransferases in Lipid A Biosynthesis. J.Biol.Chem., 289, 2014
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