1KL2
 
 | | Crystal Structure of Serine Hydroxymethyltransferase Complexed with Glycine and 5-formyl tetrahydrofolate | | Descriptor: | GLYCINE, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Trivedi, V, Gupta, A, Jala, V.R, Saravanan, P, Rao, G.S.J, Rao, N.A, Savithri, H.S, Subramanya, H.S. | | Deposit date: | 2001-12-11 | | Release date: | 2002-07-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.
J.Biol.Chem., 277, 2002
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8VIK
 | | EgtB-IV from Crocosphaera subtropica, a type IV sulfoxide synthase involved in ergothioneine biosynthesis | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.961 Å) | | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA.
Structure, 32, 2024
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8VIL
 | | EgtB-IV from Crocosphaera subtropica, an ergothioneine-biosynthetic type IV sulfoxide synthase in complex with N,N-dimethyl-histidine | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA.
Structure, 32, 2024
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4DOG
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8VH8
 | | Crystal structure of heparosan synthase 2 from Pasteurella multocida at 2.85 A | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Pedersen, L.C, Liu, J, Stancanelli, E, krahn, J.M. | | Deposit date: | 2023-12-31 | | Release date: | 2024-09-04 | | Last modified: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural and Functional Analysis of Heparosan Synthase 2 from Pasteurella multocida (PmHS2) to Improve the Synthesis of Heparin.
Acs Catalysis, 14, 2024
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5IEI
 | | X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH) based on human IGF2R domain 11 | | Descriptor: | 1,2-ETHANEDIOL, Cation-independent mannose-6-phosphate receptor, GLYCEROL, ... | | Authors: | Nicholls, R.D, Williams, C, Strickland, M, Frago, S, Hassan, A.B, Crump, M.P. | | Deposit date: | 2016-02-25 | | Release date: | 2016-05-18 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5INL
 | | Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with deoxyadenosine | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DNA (5'-D(P*AP*CP*GP*AP*AP*TP*TP*CP*G)-3'), ... | | Authors: | Schellenberg, M.J, Vilas, C.K, Williams, R.S. | | Deposit date: | 2016-03-07 | | Release date: | 2016-04-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.551 Å) | | Cite: | Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
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1KCT
 | | ALPHA1-ANTITRYPSIN | | Descriptor: | ALPHA1-ANTITRYPSIN | | Authors: | Song, H.K, Suh, S.W. | | Deposit date: | 1996-08-06 | | Release date: | 1997-01-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.46 Å) | | Cite: | Crystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loop.
FEBS Lett., 377, 1995
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2XCE
 | | Structure of YncF in complex with dUpNHpp | | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, GLYCEROL, ... | | Authors: | Garcia-Nafria, J, Burchell, L, Takezawa, M, Rzechorzek, N, Fogg, M, Wilson, K.S. | | Deposit date: | 2010-04-22 | | Release date: | 2010-08-11 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The Structure of the Genomic Bacillus Subtilis Dutpase: Novel Features in the Phe-Lid.
Acta Crystallogr.,Sect.D, 66, 2010
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5ITP
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4W5C
 | | Crystal structure analysis of cruzain with three Fragments: 1 (N-(1H-benzimidazol-2-yl)-1,3-dimethyl-pyrazole-4-carboxamide), 6 (2-amino-4,6-difluorobenzothiazole) and 9 (N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-pyrazole-4-carboxamide). | | Descriptor: | 4,6-difluoro-1,3-benzothiazol-2-amine, Cruzipain, N-(1H-benzimidazol-2-yl)-1,3-dimethyl-1H-pyrazole-4-carboxamide, ... | | Authors: | Tochowicz, A, McKerrow, J.H, Craik, C.S. | | Deposit date: | 2014-08-17 | | Release date: | 2015-04-08 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.27 Å) | | Cite: | Applying Fragments Based- Drug Design to identify multiple binding modes on cysteine protease.
To Be Published
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4W5P
 | | Prp peptide | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, PrP peptide | | Authors: | Yu, L, Lee, S.-J, Yee, V. | | Deposit date: | 2014-08-18 | | Release date: | 2015-05-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.151 Å) | | Cite: | Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
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4W67
 | | Crystal structure of Prp peptide | | Descriptor: | PrP peptide | | Authors: | Yu, L, Lee, S.-J, Yee, V. | | Deposit date: | 2014-08-20 | | Release date: | 2015-05-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.001 Å) | | Cite: | Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
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5IMH
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8VDO
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8VDP
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8VDQ
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8VDR
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8VH1
 | | CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP | | Descriptor: | CH235.I60 Fab Heavy Chain, CH235.I60 Fab Light Chain, CH505.M5 SOSIP gp120, ... | | Authors: | Henderson, R, Acharya, P. | | Deposit date: | 2023-12-30 | | Release date: | 2024-10-02 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (4.08 Å) | | Cite: | Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.
Nat Commun, 15, 2024
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8VH2
 | | CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP | | Descriptor: | CH235.12 Fab Heavy Chain, CH235.12 Fab Light Chain, CH505.M5.G458Y SOSIP gp120, ... | | Authors: | Henderson, R, Acharya, P. | | Deposit date: | 2023-12-30 | | Release date: | 2024-10-02 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4.31 Å) | | Cite: | Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.
Nat Commun, 15, 2024
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8VGW
 | | VRC01 Fab bound to the HIV-1 CH848 DE3 SOSIP | | Descriptor: | CH848 DE3 SOSIP gp120, CH848 DE3 SOSIP gp41, VRC01 Fab Heavy Chain, ... | | Authors: | Henderson, R, Acharya, P. | | Deposit date: | 2023-12-29 | | Release date: | 2024-10-02 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.
Nat Commun, 15, 2024
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4W5H
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2BV5
 | | CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 AT 1.8A RESOLUTION | | Descriptor: | GLYCEROL, SULFATE ION, TYROSINE-PROTEIN PHOSPHATASE, ... | | Authors: | Debreczeni, J.E, Barr, A.J, Eswaran, J, Smee, C, Burgess, N, Gileadi, O, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Knapp, S. | | Deposit date: | 2005-06-22 | | Release date: | 2005-07-14 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
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4W71
 | | Crystal structure of a prion peptide | | Descriptor: | PrP peptide | | Authors: | Yu, L, Lee, S.-J, Yee, V. | | Deposit date: | 2014-08-21 | | Release date: | 2015-05-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
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3GBD
 | | Crystal structure of the isomaltulose synthase SmuA from Protaminobacter rubrum | | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, Sucrose isomerase SmuA from Protaminobacter rubrum | | Authors: | Ravaud, S, Robert, X, Haser, R, Aghajari, N. | | Deposit date: | 2009-02-19 | | Release date: | 2009-05-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural determinants of product specificity of sucrose isomerases
Febs Lett., 583, 2009
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