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2MZ1
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BU of 2mz1 by Molmil
Solution structure of hnRNP C RRM in complex with 5'-UUUUC-3' RNA
Descriptor: 5'-R(*UP*UP*UP*UP*C)-3', Heterogeneous nuclear ribonucleoproteins C1/C2
Authors:Cienikova, Z, Damberger, F.F, Hall, J, Allain, F.H.-T, Maris, C.
Deposit date:2015-02-05
Release date:2015-04-08
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural and mechanistic insights into poly(uridine) tract recognition by the hnRNP C RNA recognition motif.
J.Am.Chem.Soc., 136, 2014
1E83
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BU of 1e83 by Molmil
Cytochrome c' from Alcaligenes xylosoxidans - oxidized structure
Descriptor: CYTOCHROME C', HEME C
Authors:Lawson, D.M, Stevenson, C.E.M, Andrew, C.R, Eady, R.R.
Deposit date:2000-09-15
Release date:2000-11-06
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Unprecedented Proximal Binding of Nitric Oxide to Heme: Implications for Guanylate Cyclase
Embo J., 19, 2000
2E9O
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BU of 2e9o by Molmil
Structure of h-CHK1 complexed with AA582939
Descriptor: 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID, Serine/threonine-protein kinase Chk1
Authors:Park, C.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg.Med.Chem., 15, 2007
2HD0
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Structure of the catalytic domain of hepatitis C virus NS2
Descriptor: DECYL-BETA-D-MALTOPYRANOSIDE, Protease NS2-3 (p23), octyl beta-D-glucopyranoside
Authors:Lorenz, I.C, Rice, C.M, Marcotrigiano, J.
Deposit date:2006-06-19
Release date:2006-08-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structure of the catalytic domain of the hepatitis C virus NS2-3 protease.
Nature, 442, 2006
2CYP
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BU of 2cyp by Molmil
Crystal structure of yeast cytochrome C peroxidase refined at 1.7-angstroms resolution
Descriptor: CYTOCHROME C PEROXIDASE, OXYGEN ATOM, PROTOPORPHYRIN IX CONTAINING FE
Authors:Finzel, B.C, Poulos, T.L, Kraut, J.
Deposit date:1985-08-27
Release date:1986-01-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of yeast cytochrome c peroxidase refined at 1.7-A resolution
J.Biol.Chem., 259, 1984
1YVX
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BU of 1yvx by Molmil
Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor
Descriptor: 3-[ISOPROPYL(4-METHYLBENZOYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION
Authors:Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
Deposit date:2005-02-16
Release date:2005-03-22
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
2P16
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BU of 2p16 by Molmil
Factor Xa in Complex with the Inhibitor APIXABAN (BMS-562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4-C]PYRIDINE-3-CARBOXAMIDE
Descriptor: 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE, CALCIUM ION, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)
Authors:Alexander, R.
Deposit date:2007-03-02
Release date:2007-10-16
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa.
J.Med.Chem., 50, 2007
1YWM
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Crystal structure of the N-terminal domain of group B Streptococcus alpha C protein
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, C protein alpha-antigen, GLYCEROL
Authors:Auperin, T.C, Bolduc, G.R, Baron, M.J, Heroux, A, Filman, D.J, Madoff, L.C, Hogle, J.M.
Deposit date:2005-02-18
Release date:2005-03-08
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of the N-terminal domain of the group B streptococcus alpha C protein.
J.Biol.Chem., 280, 2005
1YUY
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BU of 1yuy by Molmil
HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE GENOTYPE 2a
Descriptor: RNA-Dependent RNA polymerase, SULFATE ION
Authors:Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
Deposit date:2005-02-14
Release date:2005-03-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
1YV2
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BU of 1yv2 by Molmil
Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a
Descriptor: GLYCEROL, RNA dependent RNA polymerase, SULFATE ION
Authors:Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
Deposit date:2005-02-14
Release date:2005-03-22
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors
J.Biol.Chem., 280, 2005
1YVZ
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BU of 1yvz by Molmil
Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor
Descriptor: 3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION
Authors:Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
Deposit date:2005-02-16
Release date:2005-03-22
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
3Q80
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BU of 3q80 by Molmil
Structure of Mtb 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) Complexed with CDP-ME
Descriptor: 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL, CHLORIDE ION, ...
Authors:Reddy, M.C.M, Bruning, J.B, Thurman, C, Ioerger, T.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-01-05
Release date:2011-05-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): a candidate antitubercular drug target
Proteins, 2011
2C4G
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BU of 2c4g by Molmil
STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514
Descriptor: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ...
Authors:Cameron, A, Fogliatto, G, Pevarello, P, Fancelli, D, Vulpetti, A, Amici, R, Villa, M, Pittala, V, Ciomei, M, Mercurio, C, Bischoff, J.R, Roletto, F, Varasi, M, Brasca, M.G.
Deposit date:2005-10-19
Release date:2005-11-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:3-Amino-1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: A New Class of Cdk2 Inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
4KBY
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BU of 4kby by Molmil
mSTING/c-di-GMP
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Stimulator of interferon genes protein
Authors:Chin, K.H, Su, Y.C, Tu, J.L, Chou, S.H.
Deposit date:2013-04-24
Release date:2013-05-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
Acta Crystallogr.,Sect.D, 69, 2013
3TYV
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BU of 3tyv by Molmil
SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase
Descriptor: N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase
Authors:Lesburg, C.A, Chen, K.X.
Deposit date:2011-09-26
Release date:2012-02-01
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase.
J.Med.Chem., 55, 2012
2MXY
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BU of 2mxy by Molmil
Solution structure of hnRNP C RRM in complex with 5'-AUUUUUC-3' RNA
Descriptor: 5'-R(*AP*UP*UP*UP*UP*UP*C)-3', Heterogeneous nuclear ribonucleoproteins C1/C2
Authors:Cienikova, Z, Damberger, F.F, Hall, J, Allain, F.H.-T, Maris, C.
Deposit date:2015-01-19
Release date:2015-02-25
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural and mechanistic insights into poly(uridine) tract recognition by the hnRNP C RNA recognition motif.
J.Am.Chem.Soc., 136, 2014
1TNX
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BU of 1tnx by Molmil
NMR SOLUTION STRUCTURE OF CALCIUM SATURATED SKELETAL MUSCLE TROPONIN C
Descriptor: TROPONIN C
Authors:Slupsky, C.M, Sykes, B.D.
Deposit date:1995-08-23
Release date:1995-10-15
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR solution structure of calcium-saturated skeletal muscle troponin C.
Biochemistry, 34, 1995
1TNW
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BU of 1tnw by Molmil
NMR SOLUTION STRUCTURE OF CALCIUM SATURATED SKELETAL MUSCLE TROPONIN C
Descriptor: TROPONIN C
Authors:Slupsky, C.M, Sykes, B.D.
Deposit date:1995-08-23
Release date:1995-10-15
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR solution structure of calcium-saturated skeletal muscle troponin C.
Biochemistry, 34, 1995
2E9N
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BU of 2e9n by Molmil
Structure of h-CHK1 complexed with A767085
Descriptor: 3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE, Serine/threonine-protein kinase Chk1
Authors:Park, C.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg.Med.Chem., 15, 2007
3NWV
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BU of 3nwv by Molmil
Human cytochrome c G41S
Descriptor: Cytochrome c, HEME C
Authors:Fagerlund, R.D, Wilbanks, S.M.
Deposit date:2010-07-11
Release date:2011-03-09
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Proapoptotic G41S Mutation to Human Cytochrome c Alters the Heme Electronic Structure and Increases the Electron Self-Exchange Rate.
J.Am.Chem.Soc., 133, 2011
2EXV
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BU of 2exv by Molmil
Crystal structure of the F7A mutant of the cytochrome c551 from Pseudomonas aeruginosa
Descriptor: ACETIC ACID, Cytochrome c-551, HEME C
Authors:Bonivento, D, Di Matteo, A, Borgia, A, Travaglini-Allocatelli, C, Brunori, M.
Deposit date:2005-11-09
Release date:2006-02-07
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Unveiling a Hidden Folding Intermediate in c-Type Cytochromes by Protein Engineering
J.Biol.Chem., 281, 2006
1PKG
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BU of 1pkg by Molmil
Structure of a c-Kit Kinase Product Complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, c-kit protein
Authors:Mol, C.D, Lim, K.B, Sridhar, V, Zou, H, Chien, E.Y.T, Sang, B.-C, Nowakowski, J, Kassel, D.B, Cronin, C.N, McRee, D.E.
Deposit date:2003-06-05
Release date:2003-08-12
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation.
J.Biol.Chem., 278, 2003
2PN4
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BU of 2pn4 by Molmil
Crystal Structure of Hepatitis C Virus IRES Subdomain IIa
Descriptor: 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3', 5'-R(*GP*CP*GP*(5BU)P*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*(5BU)P*CP*CP*GP*G)-3', STRONTIUM ION
Authors:Zhao, Q, Han, Q, Kissinger, C.R, Thompson, P.A.
Deposit date:2007-04-23
Release date:2008-04-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structure of hepatitis C virus IRES subdomain IIa.
Acta Crystallogr.,Sect.D, 64, 2008
2D3U
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BU of 2d3u by Molmil
X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with non-nucleoside analogue inhibitor
Descriptor: 5-(4-CYANOPHENYL)-3-{[(2-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID, polyprotein
Authors:Biswal, B.K, Wang, M, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Bedard, J, James, M.N.G.
Deposit date:2005-10-02
Release date:2006-08-01
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
J.Mol.Biol., 361, 2006
1HJG
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Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase: The role of arginine-258
Descriptor: 3-METHYL-2-OXOBUTANOIC ACID, DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (II) ION
Authors:Lee, H.J, Lloyd, M.D, Clifton, I.J, Harlos, K, Dubus, A, Baldwin, J.E, Frere, J.M, Schofield, C.J.
Deposit date:2001-01-15
Release date:2001-06-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258
J.Biol.Chem., 276, 2001

238582

数据于2025-07-09公开中

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