8T8C
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![BU of 8t8c by Molmil](/molmil-images/mine/8t8c) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. | Deposit date: | 2023-06-22 | Release date: | 2023-07-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
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8T8B
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![BU of 8t8b by Molmil](/molmil-images/mine/8t8b) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. | Deposit date: | 2023-06-22 | Release date: | 2023-07-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
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8T8A
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![BU of 8t8a by Molmil](/molmil-images/mine/8t8a) | |
8T89
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![BU of 8t89 by Molmil](/molmil-images/mine/8t89) | |
8T88
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![BU of 8t88 by Molmil](/molmil-images/mine/8t88) | |
8T87
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![BU of 8t87 by Molmil](/molmil-images/mine/8t87) | |
8T86
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![BU of 8t86 by Molmil](/molmil-images/mine/8t86) | |
8T85
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![BU of 8t85 by Molmil](/molmil-images/mine/8t85) | Structure of RssB bound to beryllofluoride | Descriptor: | BERYLLIUM TRIFLUORIDE ION, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Brugger, C, Schwartz, J, Deaconescu, A.M. | Deposit date: | 2023-06-21 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structure of phosphorylated-like RssB, the adaptor delivering sigma s to the ClpXP proteolytic machinery, reveals an interface switch for activation. J.Biol.Chem., 299, 2023
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8T84
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![BU of 8t84 by Molmil](/molmil-images/mine/8t84) | Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled beta-sheet, includes hexafluoroisopropanol | Descriptor: | 1,1,1,3,3,3-hexafluoropropan-2-ol, Racemic mixture of amyloid beta segment 35-MVGGVV-40 | Authors: | Sawaya, M.R, Raskatov, J.A, Hazari, A. | Deposit date: | 2023-06-21 | Release date: | 2023-11-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.101 Å) | Cite: | Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets. J.Am.Chem.Soc., 145, 2023
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8T83
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![BU of 8t83 by Molmil](/molmil-images/mine/8t83) | |
8T82
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![BU of 8t82 by Molmil](/molmil-images/mine/8t82) | Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled beta-sheet, includes pentafluoropropionic acid | Descriptor: | amyloid beta segment 35-MVGGVV-40, racemic mixture, pentafluoropropanoic acid | Authors: | Sawaya, M.R, Raskatov, J.A, Hazari, A. | Deposit date: | 2023-06-21 | Release date: | 2023-11-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets. J.Am.Chem.Soc., 145, 2023
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8T81
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![BU of 8t81 by Molmil](/molmil-images/mine/8t81) | |
8T80
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![BU of 8t80 by Molmil](/molmil-images/mine/8t80) | Sequence specific (AATT) orientation of Hoechst molecules at two unique minor groove binding sites within a self-assembled 3D DNA lattice (4x5) | Descriptor: | 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DNA (5'-D(*GP*AP*GP*AP*AP*TP*TP*CP*CP*TP*GP*AP*CP*GP*AP*CP*AP*AP*TP*TP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*TP*GP*T)-3'), ... | Authors: | Simmons, C.R, MacCulloch, T, Stephanopoulos, N, Yan, H. | Deposit date: | 2023-06-21 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Site-Specific Arrangement and Structure Determination of Minor Groove Binding Molecules in Self-Assembled Three-Dimensional DNA Crystals. J.Am.Chem.Soc., 145, 2023
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8T7Z
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![BU of 8t7z by Molmil](/molmil-images/mine/8t7z) | |
8T7Y
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![BU of 8t7y by Molmil](/molmil-images/mine/8t7y) | |
8T7X
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![BU of 8t7x by Molmil](/molmil-images/mine/8t7x) | Sequence specific (AATT) orientation of DAPI molecules at two unique minor groove binding sites within a self-assembled 3D DNA lattice (4x5) | Descriptor: | 6-AMIDINE-2-(4-AMIDINO-PHENYL)INDOLE, CACODYLATE ION, DNA (5'-D(*GP*AP*GP*AP*AP*TP*TP*CP*CP*TP*GP*AP*CP*GP*AP*CP*AP*AP*TP*TP*A)-3'), ... | Authors: | Simmons, C.R, MacCulloch, T, Stephanopoulos, N, Yan, H. | Deposit date: | 2023-06-21 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | Site-Specific Arrangement and Structure Determination of Minor Groove Binding Molecules in Self-Assembled Three-Dimensional DNA Crystals. J.Am.Chem.Soc., 145, 2023
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8T7W
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![BU of 8t7w by Molmil](/molmil-images/mine/8t7w) | |
8T7V
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![BU of 8t7v by Molmil](/molmil-images/mine/8t7v) | |
8T7U
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![BU of 8t7u by Molmil](/molmil-images/mine/8t7u) | ADP-bound Bcs1 (unsymmetrized) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Mitochondrial chaperone BCS1 | Authors: | Zhan, J, Xia, D. | Deposit date: | 2023-06-21 | Release date: | 2024-06-05 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate. Nat Commun, 15, 2024
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8T7T
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![BU of 8t7t by Molmil](/molmil-images/mine/8t7t) | |
8T7S
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![BU of 8t7s by Molmil](/molmil-images/mine/8t7s) | SpRYmer bound to NAC PAM DNA | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ... | Authors: | Hibshman, G.N, Bravo, J.P.K, Taylor, D.W. | Deposit date: | 2023-06-21 | Release date: | 2024-05-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nat Commun, 15, 2024
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8T7Q
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![BU of 8t7q by Molmil](/molmil-images/mine/8t7q) | Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors | Descriptor: | 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Tang, Y, Nguyen, V, Wilbur, J.D. | Deposit date: | 2023-06-21 | Release date: | 2023-10-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors. J.Med.Chem., 66, 2023
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8T7P
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![BU of 8t7p by Molmil](/molmil-images/mine/8t7p) | X-ray crystal structure of PfA-M1(M462S) | Descriptor: | Aminopeptidase N, GLYCEROL, MAGNESIUM ION, ... | Authors: | Yang, W, Drinkwater, N, Webb, C.T, McGowan, S. | Deposit date: | 2023-06-21 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational dynamics of the Plasmodium falciparum M1 aminopeptidase. To Be Published
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8T7M
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![BU of 8t7m by Molmil](/molmil-images/mine/8t7m) | Iron and Copper bound HftA from Treponema denticola | Descriptor: | COPPER (II) ION, FE (III) ION, Pathogen-specific surface antigen, ... | Authors: | Corbett, B.W, Suits, M.D. | Deposit date: | 2023-06-20 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structural and functional characterization of the high-affinity ferrous iron transport protein HftA from Treponema denticola To Be Published
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8T7L
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![BU of 8t7l by Molmil](/molmil-images/mine/8t7l) | Copper bound HftA from Treponema denticola | Descriptor: | COPPER (II) ION, Pathogen-specific surface antigen, putative, ... | Authors: | Corbett, B.W, Suits, M.D. | Deposit date: | 2023-06-20 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural and functional characterization of the high-affinity ferrous iron transport protein HftA from Treponema denticola To Be Published
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