9ARH
| Rat GluN1-GluN2B NMDA receptor channel in complex with glycine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2024-02-23 | Release date: | 2024-07-31 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor. Nature, 632, 2024
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9B69
| GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of NTD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | Authors: | Nakagawa, T, Greger, I.H. | Deposit date: | 2024-03-23 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
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9B63
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9B68
| GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of NTD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | Authors: | Nakagawa, T, Greger, I.H. | Deposit date: | 2024-03-23 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
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9B5Z
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9ARG
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9ARI
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9B60
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9ARE
| Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation | Descriptor: | GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2024-02-23 | Release date: | 2024-07-31 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor. Nature, 632, 2024
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9B61
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9B67
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8JJ1
| Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in two fab conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 2G7 Heavy Chain, ... | Authors: | Wang, H, Zhu, S. | Deposit date: | 2023-05-29 | Release date: | 2024-06-05 | Last modified: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis. Nat.Struct.Mol.Biol., 2024
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8JIZ
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8JF7
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8JJ2
| Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in one fab conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab2G7 Heavy Chain, ... | Authors: | Wang, H, Zhu, S. | Deposit date: | 2023-05-29 | Release date: | 2024-06-05 | Last modified: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis. Nat.Struct.Mol.Biol., 2024
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8JJ0
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7RZ8
| Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist quisqualate | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Glutamate receptor 2 | Authors: | Klykov, O.V, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I. | Deposit date: | 2021-08-27 | Release date: | 2021-10-27 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L. Mol.Cell, 81, 2021
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7RZ6
| Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist glutamate | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID, Glutamate receptor 2 | Authors: | Klykov, O.V, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I. | Deposit date: | 2021-08-27 | Release date: | 2021-10-27 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L. Mol.Cell, 81, 2021
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7RZA
| Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 2 | Authors: | Gangwar, S.P, Klykov, O.V, Yelshanskaya, M.V, Sobolevsky, A.I. | Deposit date: | 2021-08-27 | Release date: | 2021-10-27 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.26 Å) | Cite: | Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L. Mol.Cell, 81, 2021
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7RYY
| Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist glutamate | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID, Glutamate receptor 2 | Authors: | Klykov, O.V, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I. | Deposit date: | 2021-08-26 | Release date: | 2021-10-27 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L. Mol.Cell, 81, 2021
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7RYZ
| Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 2 | Authors: | Gangwar, S.P, Klykov, O.V, Yelshanskaya, M.V, Sobolevsky, A.I. | Deposit date: | 2021-08-26 | Release date: | 2021-10-27 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.15 Å) | Cite: | Structure and desensitization of AMPA receptor complexes with type II TARP gamma 5 and GSG1L. Mol.Cell, 81, 2021
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7QHH
| Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ... | Authors: | Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H. | Deposit date: | 2021-12-12 | Release date: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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7QHB
| Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ... | Authors: | Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H. | Deposit date: | 2021-12-11 | Release date: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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8I0B
| The crystal structure of human glutamate receptor 2 in complex with LT-102 | Descriptor: | 8-[4-(2-fluorophenyl)phenyl]-3,4-dihydro-1,2$l^{6},3-benzoxathiazine 2,2-dioxide, CHLORIDE ION, Glutamate receptor 2,Isoform Flip of Glutamate receptor 2, ... | Authors: | Qi, X.Y, Wu, C.Y. | Deposit date: | 2023-01-10 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structure of the human GluA2 LBD in complex with LT-102 To Be Published
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8P3T
| Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 1 | Descriptor: | Glutamate receptor 1 flip isoform, Voltage-dependent calcium channel gamma-3 subunit | Authors: | Zhang, D, Krieger, J, Yamashita, K, Greger, I. | Deposit date: | 2023-05-18 | Release date: | 2023-08-30 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
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