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5WG8
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BU of 5wg8 by Molmil
Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density
Descriptor: (1S,2R,3S,4R)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:D'Arcy, B.M, Swingle, M.R, Honkanen, R.E, Prakash, A.
Deposit date:2017-07-13
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
Mol. Cancer Ther., 18, 2019
6G46
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BU of 6g46 by Molmil
Red kidney bean purple acid phosphatase in complex with 2-(Naphthalen-1-yl)thiazole-4-carboxylic acid
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-naphthalen-1-yl-1,3-thiazole-4-carboxylic acid, ...
Authors:Feder, D.F.
Deposit date:2018-03-26
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics.
Eur J Med Chem, 157, 2018
6G0J
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BU of 6g0j by Molmil
Inactive Fe-PP1
Descriptor: FE (III) ION, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Salvi, F, Barabas, O, Koehn, M.
Deposit date:2018-03-18
Release date:2018-11-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Effects of stably incorporated iron on protein phosphatase-1 structure and activity.
FEBS Lett., 592, 2018
6G0I
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BU of 6g0i by Molmil
Active Fe-PP1
Descriptor: FE (III) ION, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Salvi, F, Barabas, O, Koehn, M.
Deposit date:2018-03-18
Release date:2018-11-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Effects of stably incorporated iron on protein phosphatase-1 structure and activity.
FEBS Lett., 592, 2018
6CZO
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BU of 6czo by Molmil
The KNL1-PP1 Holoenzyme
Descriptor: CASC5 protein, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Bajaj, R, Peti, W, Page, R.
Deposit date:2018-04-09
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive.
Structure, 26, 2018
6DNO
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BU of 6dno by Molmil
Crystal structure of Protein Phosphatase 1 (PP1) bound to the muscle glycogen-targeting subunit (Gm)
Descriptor: Microcystin-LR, Protein phosphatase 1 regulatory subunit 3A, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Authors:Choy, M.S, Kumar, G.S, Peti, W, Page, R.
Deposit date:2018-06-07
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme.
Sci Adv, 4, 2018
6HMF
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BU of 6hmf by Molmil
D-family DNA polymerase - DP1 subunit (3'-5' proof-reading exonuclease) H451 proof-reading deficient variant
Descriptor: ACETATE ION, CACODYLATE ION, CALCIUM ION, ...
Authors:Raia, P, Delarue, M, Sauguet, L.
Deposit date:2018-09-12
Release date:2019-01-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.
PLoS Biol., 17, 2019
6HMS
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BU of 6hms by Molmil
Cryo-EM map of DNA polymerase D from Pyrococcus abyssi in complex with DNA
Descriptor: DNA (5'-D(*GP*AP*GP*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*TP*GP*AP*CP*GP*CP*GP*GP*CP*CP*CP*GP*TP*CP*TP*C)-3'), DNA polymerase II large subunit,DNA polymerase II large subunit, ...
Authors:Raia, P, Carroni, M, Sauguet, L.
Deposit date:2018-09-12
Release date:2019-01-30
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.
PLoS Biol., 17, 2019
6GHM
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BU of 6ghm by Molmil
Structure of PP1 alpha phosphatase bound to ASPP2
Descriptor: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Apoptosis-stimulating of p53 protein 2, ...
Authors:Mouilleron, S, Bertran, T.M, Tapon, N, Zhou, Y.
Deposit date:2018-05-08
Release date:2019-02-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail.
Nat Commun, 10, 2019
5ZT0
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BU of 5zt0 by Molmil
Crystal Structure of Protein Phosphate 1 Complexed with PP1 binding domain of GL
Descriptor: MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1 regulatory subunit 3B, ...
Authors:Yu, J, Xiang, S.
Deposit date:2018-05-01
Release date:2019-03-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.3204267 Å)
Cite:Structural basis for protein phosphatase 1 recruitment by glycogen-targeting subunits
FEBS J., 285, 2018
5ZQV
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BU of 5zqv by Molmil
Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GM
Descriptor: CITRATE ANION, MANGANESE (II) ION, Protein phosphatase 1 regulatory subunit 3A, ...
Authors:Yu, J, Xiang, S.
Deposit date:2018-04-20
Release date:2019-03-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis for protein phosphatase 1 recruitment by glycogen-targeting subunits.
FEBS J., 285, 2018
6NVP
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BU of 6nvp by Molmil
Crystal structure of Pseudomonas putida nuclease MPE
Descriptor: MANGANESE (II) ION, Nuclease MPE
Authors:Goldgur, Y, Shuman, S, Ejaz, A.
Deposit date:2019-02-05
Release date:2019-03-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activity and structure ofPseudomonas putidaMPE, a manganese-dependent single-strand DNA endonuclease encoded in a nucleic acid repair gene cluster.
J.Biol.Chem., 294, 2019
6NVO
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BU of 6nvo by Molmil
Crystal structure of Pseudomonas putida nuclease MPE
Descriptor: MANGANESE (II) ION, Nuclease MPE
Authors:Goldgur, Y, Shuman, S, Ejaz, A.
Deposit date:2019-02-05
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:Activity and structure ofPseudomonas putidaMPE, a manganese-dependent single-strand DNA endonuclease encoded in a nucleic acid repair gene cluster.
J.Biol.Chem., 294, 2019
6HWR
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BU of 6hwr by Molmil
Red kidney bean purple acid phosphatase in complex with adenosine divanadate
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Feder, D, Gahan, L.R, McGeary, R.P, Guddat, L.W, Schenk, G.
Deposit date:2018-10-13
Release date:2019-04-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Binding Mode of an ADP Analogue to a Metallohydrolase Mimics the Likely Transition State.
Chembiochem, 20, 2019
6DCX
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BU of 6dcx by Molmil
iASPP-PP-1c structure and targeting of p53
Descriptor: RelA-associated inhibitor, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Authors:Glover, J.N.M, Zhou, Y, Edwards, R.A.
Deposit date:2018-05-08
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.408 Å)
Cite:Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
Structure, 27, 2019
6NUC
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BU of 6nuc by Molmil
Structure of Calcineurin in complex with NHE1 peptide
Descriptor: CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ...
Authors:Wang, X, Page, R, Peti, W.
Deposit date:2019-01-31
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin.
Nat Commun, 10, 2019
6NUU
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BU of 6nuu by Molmil
Structure of Calcineurin mutant in complex with NHE1 peptide
Descriptor: CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ...
Authors:Wang, X, Page, R, Peti, W.
Deposit date:2019-02-02
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin.
Nat Commun, 10, 2019
6NUF
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BU of 6nuf by Molmil
Structure of Calcineurin in complex with NHE1 peptide
Descriptor: CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ...
Authors:Wang, X, Page, R, Peti, W.
Deposit date:2019-01-31
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin.
Nat Commun, 10, 2019
6HXW
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BU of 6hxw by Molmil
structure of human CD73 in complex with antibody IPH53
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, IPH53 heavy chain, ...
Authors:Roussel, A, Amigues, B.
Deposit date:2018-10-18
Release date:2019-08-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies.
Cell Rep, 27, 2019
6S6V
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BU of 6s6v by Molmil
Resting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ATPgS
Descriptor: MAGNESIUM ION, MANGANESE (II) ION, Nuclease SbcCD subunit C, ...
Authors:Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P.
Deposit date:2019-07-03
Release date:2019-09-04
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Mol.Cell, 76, 2019
6S85
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BU of 6s85 by Molmil
Cutting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), DNA (32-MER), ...
Authors:Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P.
Deposit date:2019-07-08
Release date:2019-09-04
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Mol.Cell, 76, 2019
6OFD
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BU of 6ofd by Molmil
The crystal structure of octadecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Feder, D, Schenk, G, Guddat, L.W, Hussein, W.M, McGeary, R.P, Kan, M.W.
Deposit date:2019-03-29
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis.
Eur.J.Med.Chem., 182, 2019
6OF5
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BU of 6of5 by Molmil
The crystal structure of dodecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, ...
Authors:Feder, D, Schenk, G, Guddat, L.W, Hussein, W.M, McGeary, R.P.
Deposit date:2019-03-28
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis.
Eur.J.Med.Chem., 182, 2019
6TZ6
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BU of 6tz6 by Molmil
Crystal Structure of Candida Albicans Calcineurin A, Calcineurin B, FKBP12 and FK506 (Tacrolimus)
Descriptor: 1,2-ETHANEDIOL, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, ...
Authors:Fox III, D, Lukacs, C.M.
Deposit date:2019-08-10
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
Nat Commun, 10, 2019
6OBN
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BU of 6obn by Molmil
The crystal structure of coexpressed SDS22:PP1 complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, FE (III) ION, ...
Authors:Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R.
Deposit date:2019-03-21
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:SDS22 selectively recognizes and traps metal-deficient inactive PP1.
Proc.Natl.Acad.Sci.USA, 116, 2019

221051

数据于2024-06-12公开中

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