PDB: 338 resultsInfo pagesStatus searchChemie searchBIRD

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4G3E	Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1) Descriptor: (2R)-4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol, NF-kappa-beta-inducing kinase, SULFATE ION Authors: Hymowitz, S.G, de Leon-Boenig, G. Deposit date: 2012-07-13 Release date: 2012-08-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site. Structure, 20, 2012
4DGL	Crystal Structure of the CK2 Tetrameric Holoenzyme Descriptor: Casein kinase II subunit alpha, Casein kinase II subunit beta, ZINC ION Authors: Lolli, G, Battistutta, R. Deposit date: 2012-01-26 Release date: 2012-05-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization. Acs Chem.Biol., 7, 2012
4JC3	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-21 Release date: 2013-05-15 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4GA7	Crystal structure of human serpinB1 mutant Descriptor: Leukocyte elastase inhibitor Authors: Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. Deposit date: 2012-07-25 Release date: 2013-01-16 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
4F9B	Human CDC7 kinase in complex with DBF4 and PHA767491 Descriptor: 2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one, Cell division cycle 7-related protein kinase, Protein DBF4 homolog A, ... Authors: Hughes, S, Cherepanov, P. Deposit date: 2012-05-18 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of human CDC7 kinase in complex with its activator DBF4. Nat.Struct.Mol.Biol., 19, 2012
4GAW	Crystal structure of active human granzyme H Descriptor: CHLORIDE ION, Granzyme H, SULFATE ION Authors: Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. Deposit date: 2012-07-25 Release date: 2013-01-16 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
4FWE	Native structure of LSD2 /AOF1/KDM1b in spacegroup of C2221 at 2.13A Descriptor: CITRATE ANION, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1B, ... Authors: Zhang, Q, Chen, Z. Deposit date: 2012-07-01 Release date: 2013-01-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res., 23, 2013
4G3D	Crystal structure of human NF-kappaB inducing kinase (NIK) Descriptor: MAGNESIUM ION, NF-kappa-beta-inducing kinase Authors: Hymowitz, S.G, de Leon-Boenig, G. Deposit date: 2012-07-13 Release date: 2012-08-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site. Structure, 20, 2012
4F99	Human CDC7 kinase in complex with DBF4 and nucleotide Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division cycle 7-related protein kinase, MAGNESIUM ION, ... Authors: Hughes, S, Cherepanov, P. Deposit date: 2012-05-18 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Crystal structure of human CDC7 kinase in complex with its activator DBF4. Nat.Struct.Mol.Biol., 19, 2012
4JDD	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-25 Release date: 2013-05-15 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4JJ3	Crystal structure of MamP soaked with iron(II) Descriptor: HEME C, MamP Authors: Siponen, M, Pignol, D, Arnoux, P. Deposit date: 2013-03-07 Release date: 2013-10-09 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural insight into magnetochrome-mediated magnetite biomineralization. Nature, 502, 2013
4FWF	Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.1, Lysine-specific histone demethylase 1B, ... Authors: Zhang, Q, Chen, Z. Deposit date: 2012-07-01 Release date: 2013-01-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res., 23, 2013
4EFX	Highly biologically active insulin with additional disulfide bond Descriptor: Insulin, ZINC ION Authors: Norrman, M, Vinther, T.N. Deposit date: 2012-03-30 Release date: 2013-03-06 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Insulin analog with additional disulfide bond has increased stability and preserved activity. Protein Sci., 22, 2013
4EUX	Structure of neuronal nitric oxide synthase heme domain in complex with 6-(5-(((3R,4R)-4-((6-amino-4-methylpyridin-2-yl)methyl)pyrrolidin-3-yl)oxy)pentyl)-4-methylpyridin-2-amine Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-[5-({(3R,4R)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}oxy)pentyl]-4-methylpyridin-2-amine, ACETATE ION, ... Authors: Li, H, Poulos, T.L. Deposit date: 2012-04-25 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. J.Am.Chem.Soc., 134, 2012
4I1Q	Crystal Structure of hBRAP1 N-BAR domain Descriptor: Bridging integrator 2 Authors: Sanchez-Barrena, M.J. Deposit date: 2012-11-21 Release date: 2013-02-06 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Bin2 Is a Membrane Sculpting N-BAR Protein That Influences Leucocyte Podosomes, Motility and Phagocytosis Plos One, 7, 2012
4F9C	Human CDC7 kinase in complex with DBF4 and XL413 Descriptor: 8-chloro-2-[(2S)-pyrrolidin-2-yl][1]benzofuro[3,2-d]pyrimidin-4(3H)-one, Cell division cycle 7-related protein kinase, Protein DBF4 homolog A, ... Authors: Hughes, S, Cherepanov, P. Deposit date: 2012-05-18 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Crystal structure of human CDC7 kinase in complex with its activator DBF4. Nat.Struct.Mol.Biol., 19, 2012
4G3C	Crystal structure of apo murine Nf-kappaB inducing kinase (NIK) Descriptor: NF-kappa-beta-inducing kinase, SULFATE ION Authors: Hymowitz, S.G, de Leon-Boenig, G. Deposit date: 2012-07-13 Release date: 2012-08-08 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site. Structure, 20, 2012
4IGN	2.32 Angstrom X-ray Crystal structure of R47A mutant of human ACMSD Descriptor: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, ZINC ION Authors: Liu, F, Liu, A. Deposit date: 2012-12-17 Release date: 2014-05-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.329 Å) Cite: Human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD): A structural and mechanistic unveiling. Proteins, 83, 2015
4LCQ	The crystal structure of di-Zn dihydropyrimidinase in complex with NCBI Descriptor: (2S)-3-(carbamoylamino)-2-methylpropanoic acid, ZINC ION, dihydropyrimidinase Authors: Hsieh, Y.C, Chen, M.C, Hsu, C.C, Chan, S.I, Yang, Y.S, Chen, C.J. Deposit date: 2013-06-22 Release date: 2013-09-18 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Crystal structures of vertebrate dihydropyrimidinase and complexes from Tetraodon nigroviridis with lysine carbamylation: metal and structural requirements for post-translational modification and function. J.Biol.Chem., 288, 2013
4F9A	Human CDC7 kinase in complex with DBF4 and nucleotide Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division cycle 7-related protein kinase, MAGNESIUM ION, ... Authors: Hughes, S, Cherepanov, P. Deposit date: 2012-05-18 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Crystal structure of human CDC7 kinase in complex with its activator DBF4. Nat.Struct.Mol.Biol., 19, 2012
4H5C	Crystal structure of human FPPS in ternary complex with YS0470 and inorganic phosphate Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. Deposit date: 2012-09-18 Release date: 2012-12-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Struct.Biol., 12, 2012
4LCS	The crystal structure of di-Zn dihydropyrimidinase in complex with hydantoin Descriptor: Chromosome 8 SCAF14545, whole genome shotgun sequence, ZINC ION, ... Authors: Hsieh, Y.C, Chen, M.C, Hsu, C.C, Chan, S.I, Yang, Y.S. Deposit date: 2013-06-23 Release date: 2013-09-18 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of vertebrate dihydropyrimidinase and complexes from Tetraodon nigroviridis with lysine carbamylation: metal and structural requirements for post-translational modification and function. J.Biol.Chem., 288, 2013
4H5E	Crystal structure of human FPPS in ternary complex with YS0470 and isopentenyl pyrophosphate Descriptor: Farnesyl pyrophosphate synthase, ISOPENTYL PYROPHOSPHATE, MAGNESIUM ION, ... Authors: Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. Deposit date: 2012-09-18 Release date: 2012-12-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Struct.Biol., 12, 2012
4LCR	The crystal structure of di-Zn dihydropyrimidinase in complex with NCBA Descriptor: Chromosome 8 SCAF14545, whole genome shotgun sequence, N-(AMINOCARBONYL)-BETA-ALANINE, ... Authors: Hsieh, Y.C, Chen, M.C, Hsu, C.C, Chan, S.I, Yang, Y.S, Chen, C.J. Deposit date: 2013-06-22 Release date: 2013-09-18 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of vertebrate dihydropyrimidinase and complexes from Tetraodon nigroviridis with lysine carbamylation: metal and structural requirements for post-translational modification and function. J.Biol.Chem., 288, 2013
4LDU	Crystal structure of the DNA binding domain of Arabidopsis thaliana auxin response factor 5 Descriptor: Auxin response factor 5, CHLORIDE ION Authors: Boer, D.R, Freire-Rios, A, van den Berg, W.M.A, Weijers, D, Coll, M. Deposit date: 2013-06-25 Release date: 2014-02-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural Basis for DNA Binding Specificity by the Auxin-Dependent ARF Transcription Factors. Cell(Cambridge,Mass.), 156, 2014

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