PDB Search results for query - 日本蛋白质结构数据库

PDB: 1657 results

Crystal structure of SARS coronavirus main protease complexed with Cm-FF-H (soaking)
Descriptor:	3C-like proteinase, N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-06-29
Release date:	2011-09-07
Last modified:	2012-12-12
Method:	X-RAY DIFFRACTION (1.99 Å)
Cite:	Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res., 92, 2011

3SNC

Crystal structure of SARS coronavirus main protease complexed with Ac-NSTSQ-H (soaking)
Descriptor:	3C-like proteinase, DIMETHYL SULFOXIDE, Peptide aldehyde inhibitor Ac-NSTSQ-H
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-06-29
Release date:	2011-09-07
Last modified:	2012-12-12
Method:	X-RAY DIFFRACTION (2.58 Å)
Cite:	Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res., 92, 2011

3SNB

Crystal structure of SARS coronavirus main protease complexed with Ac-DSFDQ-H (soaking)
Descriptor:	3C-like proteinase, Peptide aldehyde inhibitor Ac-DSFDQ-H
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-06-29
Release date:	2011-09-07
Last modified:	2012-12-12
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res., 92, 2011

3SNA

Crystal structure of SARS coronavirus main protease complexed with Ac-NSFSQ-H (soaking)
Descriptor:	3C-like proteinase, Peptide aldehyde inhibitor Ac-NSFSQ-H
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-06-29
Release date:	2011-09-07
Last modified:	2012-12-12
Method:	X-RAY DIFFRACTION (3.05 Å)
Cite:	Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res., 92, 2011

3SZN

Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester SG75
Descriptor:	3C-like proteinase, ETHYL (4R)-4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-07-19
Release date:	2012-07-25
Last modified:	2017-11-08
Method:	X-RAY DIFFRACTION (1.69 Å)
Cite:	Crystal structures of SARS-Cov main protease complexed with a series of unsaturated esters To be Published

2K7X

solution structure of C-terminal domain of SARS-CoV main protease
Descriptor:	SARS-CoV main protease
Authors:	Xia, B, Zhong, N.
Deposit date:	2008-08-28
Release date:	2009-05-12
Last modified:	2024-05-22
Method:	SOLUTION NMR
Cite:	C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer. Protein Sci., 18, 2009

2GX4

Crystal structure of SARS coronavirus 3CL protease inhibitor complex
Descriptor:	3C-like proteinase, N-[(BENZYLOXY)CARBONYL]-O-(TERT-BUTYL)-L-THREONYL-3-CYCLOHEXYL-N-[(1S)-2-HYDROXY-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}ETHYL]-L-ALANINAMIDE
Authors:	Hsu, M.F, Wang, A.H.-J.
Deposit date:	2006-05-08
Release date:	2007-05-08
Last modified:	2020-04-08
Method:	X-RAY DIFFRACTION (1.93 Å)
Cite:	Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor. J.Med.Chem., 49, 2006

2GZ9

Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main Protease
Descriptor:	Replicase polyprotein 1ab
Authors:	Lu, I.L, Wu, S.Y.
Deposit date:	2006-05-11
Release date:	2006-08-29
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.17 Å)
Cite:	Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease J.Med.Chem., 49, 2006

3SND

Crystal structure of SARS coronavirus main protease complexed with Ac-ESTLQ-H (cocrystallization)
Descriptor:	(4R)-2-METHYLPENTANE-2,4-DIOL, 3C-like proteinase, Peptide aldehyde inhibitor Ac-ESTLQ-H
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-06-29
Release date:	2011-09-07
Last modified:	2012-12-12
Method:	X-RAY DIFFRACTION (1.89 Å)
Cite:	Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res., 92, 2011

3SNE

Crystal structure of SARS coronavirus main protease complexed with Ac-ESTLQ-H (Soaking)
Descriptor:	2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3C-like proteinase, Peptide aldehyde inhibitor Ac-ESTLQ-H
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-06-29
Release date:	2011-09-07
Last modified:	2012-12-12
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res., 92, 2011

2HOB

Crystal structure of SARS-CoV main protease with authentic N and C-termini in complex with a Michael acceptor N3
Descriptor:	N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE, Replicase polyprotein 1ab
Authors:	Xue, X, Yang, H, Shen, W, Zhao, Q, Li, J, Rao, Z.
Deposit date:	2006-07-14
Release date:	2007-04-03
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction J.Mol.Biol., 366, 2007

2GT8

Crystal structure of SARS coronavirus main peptidase (with an additional Ala at the N-terminus of each protomer) in the space group P43212
Descriptor:	3C-like proteinase
Authors:	Lee, T.-W, Cherney, M.M, Huitema, C, Liu, J, James, K.E, Powers, J.C, Eltis, L.D, James, M.N.G.
Deposit date:	2006-04-27
Release date:	2006-12-26
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase. J.Mol.Biol., 366, 2007

2GZ8

Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main Protease
Descriptor:	Replicase polyprotein 1ab, S-[5-(TRIFLUOROMETHYL)-4H-1,2,4-TRIAZOL-3-YL] 5-(PHENYLETHYNYL)FURAN-2-CARBOTHIOATE
Authors:	Lu, I.L, Wu, S.Y.
Deposit date:	2006-05-11
Release date:	2006-08-29
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.97 Å)
Cite:	Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease J.Med.Chem., 49, 2006

2GZ7

Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main Protease
Descriptor:	2-[(2,4-DICHLORO-5-METHYLPHENYL)SULFONYL]-1,3-DINITRO-5-(TRIFLUOROMETHYL)BENZENE, Replicase polyprotein 1ab
Authors:	Lu, I.L, Wu, S.Y.
Deposit date:	2006-05-11
Release date:	2006-08-29
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.856 Å)
Cite:	Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease J.Med.Chem., 49, 2006

3TIU

Crystal structure of SARS coronavirus main protease complexed with an alpha,beta-unsaturated ethyl ester inhibitor SG82
Descriptor:	DIMETHYL SULFOXIDE, ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE, SARS coronavirus main protease
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-08-22
Release date:	2012-08-22
Last modified:	2017-11-08
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters To be Published

3TIT

Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester SG81
Descriptor:	ETHYL (4R)-4-{[N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANYL]AMINO}-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE, SARS coronavirus main protease
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-08-21
Release date:	2012-08-22
Last modified:	2017-11-08
Method:	X-RAY DIFFRACTION (1.99 Å)
Cite:	Crystal structures of SARS-Cov main protease complexed with a series of unsaturated esters To be Published

3TNT

Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester inhibitor SG85
Descriptor:	N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide, SARS coronavirus main protease
Authors:	Zhu, L, Hilgenfeld, R.
Deposit date:	2011-09-02
Release date:	2012-09-05
Last modified:	2017-11-08
Method:	X-RAY DIFFRACTION (1.59 Å)
Cite:	Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters To be Published

3EAJ

Crystal structure of SARS-CoV main protease quadruple mutant STIF/A with two molecules in one asymmetric unit
Descriptor:	3C-like proteinase
Authors:	Shi, J.H, Jayaraman, S, Song, J.X.
Deposit date:	2008-08-26
Release date:	2009-09-01
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	crystal structure of SARS-CoV Mpro mutant with two molecules one ASU To be Published

3E91

Crystal structure of SARS-CoV Mpro mutant in P21 at pH6.9
Descriptor:	3C-like proteinase
Authors:	Shi, J.H, Jayaraman, S, Song, J.X.
Deposit date:	2008-08-21
Release date:	2009-08-25
Last modified:	2024-05-29
Method:	X-RAY DIFFRACTION (2.55 Å)
Cite:	Structural analysis of the activity-enhanced SARS-CoV Mpro C-terminal mutant To be Published

3EBN

A Special Dimerization of SARS-CoV Main Protease C-Terminal Domain Due to Domain-swapping
Descriptor:	Replicase polyprotein 1ab
Authors:	Zhong, N, Zhang, S, Xue, F, Kang, X, Lou, Z, Xia, B.
Deposit date:	2008-08-28
Release date:	2009-05-19
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer PROTEIN SCI., 18, 2009

3EA9

Crystal structure of SARS-CoV main protease quadruple mutant STIF/A with one molecule in one asymmetric unit
Descriptor:	3C-like proteinase
Authors:	Shi, J.H, Jayaraman, S, Song, J.X.
Deposit date:	2008-08-25
Release date:	2009-09-01
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	crystal structure of SARS-CoV Mpro quadruple mutant To be Published

3EA7

Crystal structure of SARS-CoV main protease triple mutant STI/A in space group P21
Descriptor:	3C-like proteinase
Authors:	Shi, J.H, Jayaraman, S, Song, J.X.
Deposit date:	2008-08-25
Release date:	2009-09-01
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Crystal structure of SARS-CoV Mpro mutant To be Published

3EA8

Crystal structure of SARS-CoV main protease triple mutant STI/A in space group C2
Descriptor:	3C-like proteinase
Authors:	Shi, J.H, Jayaraman, S, Song, J.X.
Deposit date:	2008-08-25
Release date:	2009-09-01
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Crystal structure of SARS-CoV Mpro mutant To be Published

3F9G

Crystal Structure of the F140A mutant of SARS-Coronovirus 3C-like Protease at pH 6.5
Descriptor:	3C-like proteinase
Authors:	Hu, T, Li, L, Jiang, H, Shen, X.
Deposit date:	2008-11-13
Release date:	2009-09-29
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure. Virology, 388, 2009

3F9F

Crystal Structure of the F140A mutant of SARS-Coronovirus 3C-like Protease at pH 6.0
Descriptor:	3C-like proteinase
Authors:	Hu, T, Li, L, Jiang, H, Shen, X.
Deposit date:	2008-11-13
Release date:	2009-09-29
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure. Virology, 388, 2009

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Total results:	1657
Displayed results:	25
Sorted by:	Hit score (from highest)
Other DB:	PFam PF05409