2GT8

Crystal structure of SARS coronavirus main peptidase (with an additional Ala at the N-terminus of each protomer) in the space group P43212

Summary for 2GT8

• Entry DOI: 10.2210/pdb2gt8/pdb
• Related: 2GTB 2GTK
• Descriptor: 3C-like proteinase (2 entities in total)
• Functional Keywords: cysteine peptidase, 3c-like, n-finger, chymotrypsin-like fold, long loop, alpha-helical domain, dimer, catalytic dyad, specificity pockets, hydrolase
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• Total number of polymer chains: 1
• Total formula weight: 33947.71

Authors

Lee, T.-W.,Cherney, M.M.,Huitema, C.,Liu, J.,James, K.E.,Powers, J.C.,Eltis, L.D.,James, M.N.G. (deposition date: 2006-04-27, release date: 2006-12-26, Last modification date: 2024-02-14)

• Primary citation: Lee, T.W.,Cherney, M.M.,Liu, J.,James, K.E.,Powers, J.C.,Eltis, L.D.,James, M.N.G.; Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase.; J.Mol.Biol., 366:916-932, 2007; PubMed: 17196984; DOI: 10.1016/j.jmb.2006.11.078

Experimental method

X-RAY DIFFRACTION (2 Å)