6KSP
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![BU of 6ksp by Molmil](/molmil-images/mine/6ksp) | |
6R8A
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![BU of 6r8a by Molmil](/molmil-images/mine/6r8a) | Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with L-methionine | Descriptor: | Glutamate receptor 3.3,Glutamate receptor 3.3, METHIONINE, SODIUM ION, ... | Authors: | Alfieri, A, Pederzoli, R, Costa, A. | Deposit date: | 2019-04-01 | Release date: | 2020-01-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel. Proc.Natl.Acad.Sci.USA, 117, 2020
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6KZM
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![BU of 6kzm by Molmil](/molmil-images/mine/6kzm) | GluK3 receptor complex with kainate | Descriptor: | Glutamate receptor ionotropic, kainate 3 | Authors: | Kumar, J, Kumari, J, Burada, A.P. | Deposit date: | 2019-09-24 | Release date: | 2020-03-04 | Method: | ELECTRON MICROSCOPY (9.6 Å) | Cite: | Structural dynamics of the GluK3-kainate receptor neurotransmitter binding domains revealed by cryo-EM. Int.J.Biol.Macromol., 149, 2020
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3C32
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![BU of 3c32 by Molmil](/molmil-images/mine/3c32) | |
3C35
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![BU of 3c35 by Molmil](/molmil-images/mine/3c35) | |
6L6F
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![BU of 6l6f by Molmil](/molmil-images/mine/6l6f) | GluK3 receptor complex with UBP301 | Descriptor: | Glutamate receptor ionotropic, kainate 3 | Authors: | Kumar, J, Kumari, J, Burada, A.P. | Deposit date: | 2019-10-28 | Release date: | 2020-03-04 | Method: | ELECTRON MICROSCOPY (10.6 Å) | Cite: | Structural dynamics of the GluK3-kainate receptor neurotransmitter binding domains revealed by cryo-EM. Int.J.Biol.Macromol., 149, 2020
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6KSS
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![BU of 6kss by Molmil](/molmil-images/mine/6kss) | |
6R88
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![BU of 6r88 by Molmil](/molmil-images/mine/6r88) | Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with glycine | Descriptor: | CHLORIDE ION, GLYCEROL, GLYCINE, ... | Authors: | Alfieri, A, Pederzoli, R, Costa, A. | Deposit date: | 2019-04-01 | Release date: | 2020-01-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel. Proc.Natl.Acad.Sci.USA, 117, 2020
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3BKI
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![BU of 3bki by Molmil](/molmil-images/mine/3bki) | Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms | Descriptor: | Glutamate receptor 2, [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide | Authors: | Cruz, L, Estebanez-Perpina, E, Pfaff, S, Borngraeber, S, Bao, N, Fletterick, R, England, P. | Deposit date: | 2007-12-06 | Release date: | 2008-09-16 | Last modified: | 2019-09-04 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J.Med.Chem., 51, 2008
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3TZA
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![BU of 3tza by Molmil](/molmil-images/mine/3tza) | Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution | Descriptor: | (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, Glutamate receptor 2,Glutamate receptor 2, SULFATE ION | Authors: | Frydenvang, K, Kastrup, J.S. | Deposit date: | 2011-09-27 | Release date: | 2011-10-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure J.Med.Chem., 54, 2011
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3U94
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![BU of 3u94 by Molmil](/molmil-images/mine/3u94) | |
3C31
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![BU of 3c31 by Molmil](/molmil-images/mine/3c31) | |
6R89
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![BU of 6r89 by Molmil](/molmil-images/mine/6r89) | Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with L-cysteine | Descriptor: | CHLORIDE ION, CYSTEINE, GLYCEROL, ... | Authors: | Alfieri, A, Pederzoli, R, Costa, A. | Deposit date: | 2019-04-01 | Release date: | 2020-01-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel. Proc.Natl.Acad.Sci.USA, 117, 2020
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3U93
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![BU of 3u93 by Molmil](/molmil-images/mine/3u93) | |
2PBW
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![BU of 2pbw by Molmil](/molmil-images/mine/2pbw) | Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex with the Partial agonist Domoic Acid at 2.5 A Resolution | Descriptor: | (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, Glutamate receptor, ionotropic kainate 1 | Authors: | Hald, H, Naur, P, Gajhede, M, Kastrup, J.S. | Deposit date: | 2007-03-29 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. J.Biol.Chem., 282, 2007
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2P2A
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![BU of 2p2a by Molmil](/molmil-images/mine/2p2a) | X-ray structure of the GluR2 ligand binding core (S1S2J) in complex with 2-Bn-tet-AMPA at 2.26A resolution | Descriptor: | 2-AMINO-3-[3-HYDROXY-5-(2-BENZYL-2H-5-TETRAZOLYL)-4-ISOXAZOLYL]-PROPIONIC ACID, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Frydenvang, K, Kastrup, J.S, Gajhede, M. | Deposit date: | 2007-03-07 | Release date: | 2007-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | A tetrazolyl-substituted subtype-selective AMPA receptor agonist. J.Med.Chem., 50, 2007
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2OJT
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![BU of 2ojt by Molmil](/molmil-images/mine/2ojt) | Structure and mechanism of kainate receptor modulation by anions | Descriptor: | (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE, BROMIDE ION, Glutamate receptor, ... | Authors: | Mayer, M.L. | Deposit date: | 2007-01-14 | Release date: | 2007-04-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure and mechanism of kainate receptor modulation by anions. Neuron, 53, 2007
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2QS4
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![BU of 2qs4 by Molmil](/molmil-images/mine/2qs4) | Crystal structure of the GluR5 ligand binding core dimer in complex with LY466195 at 1.58 Angstroms resolution | Descriptor: | (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid, AMMONIUM ION, GLYCEROL, ... | Authors: | Alushin, G.M, Jane, D.E, Mayer, M.L. | Deposit date: | 2007-07-30 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology, 60, 2011
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9B35
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![BU of 9b35 by Molmil](/molmil-images/mine/9b35) | |
9B38
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![BU of 9b38 by Molmil](/molmil-images/mine/9b38) | |
9B36
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![BU of 9b36 by Molmil](/molmil-images/mine/9b36) | |
9B37
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![BU of 9b37 by Molmil](/molmil-images/mine/9b37) | |
2QS1
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![BU of 2qs1 by Molmil](/molmil-images/mine/2qs1) | Crystal structure of the GluR5 ligand binding core dimer in complex with UBP315 at 1.80 Angstroms resolution | Descriptor: | 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)-4,5-dibromothiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ... | Authors: | Alushin, G.M, Jane, D.E, Mayer, M.L. | Deposit date: | 2007-07-30 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology, 60, 2011
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9B39
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![BU of 9b39 by Molmil](/molmil-images/mine/9b39) | |
6RUQ
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![BU of 6ruq by Molmil](/molmil-images/mine/6ruq) | Structure of GluA2cryst in complex the antagonist ZK200775 and the negative allosteric modulator GYKI53655 at 4.65 A resolution | Descriptor: | (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Krintel, C, Venskutonyte, R, Mirza, O.A, Gajhede, M, Kastrup, J.S. | Deposit date: | 2019-05-28 | Release date: | 2020-06-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (4.65 Å) | Cite: | Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2. Febs J., 288, 2021
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