5TW1
| Crystal structure of a Mycobacterium smegmatis transcription initiation complex with RbpA | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | Authors: | Hubin, E.A, Darst, S.A, Campbell, E.A. | Deposit date: | 2016-11-10 | Release date: | 2017-01-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA. Elife, 6, 2017
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5VI8
| Structure of a mycobacterium smegmatis transcription initiation complex with an upstream-fork promoter fragment | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | Authors: | Hubin, E.A, Campbell, E.A, Darst, S.A. | Deposit date: | 2017-04-14 | Release date: | 2017-04-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures. Nat Commun, 8, 2017
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6VVT
| Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and antibiotic Sorangicin | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2020-02-18 | Release date: | 2020-10-21 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.901 Å) | Cite: | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
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6CCV
| Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Rifampicin | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2018-02-07 | Release date: | 2018-08-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
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6CCE
| Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Kanglemycin A | Descriptor: | 1,2-ETHANEDIOL, DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2018-02-07 | Release date: | 2018-08-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
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6YYS
| Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State II, primary channel engaged and active site interfering | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Kouba, T, Koval, T, Krasny, L, Dohnalek, J. | Deposit date: | 2020-05-05 | Release date: | 2020-11-04 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase. Nat Commun, 11, 2020
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6YXU
| Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State I, primary channel engaged | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Kouba, T, Koval, T, Krasny, L, Dohnalek, J. | Deposit date: | 2020-05-03 | Release date: | 2020-11-04 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase. Nat Commun, 11, 2020
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8QTI
| Mycobacterium smegnatis RNAP open promoter complex with SigmaA and RbpA | Descriptor: | DNA 50-mer non-template strand, DNA 50-mer template strand, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | Deposit date: | 2023-10-12 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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8Q3I
| Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State I | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | Deposit date: | 2023-08-04 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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6VVS
| Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with antibiotic Sorangicin | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | Authors: | Lilic, M, Braffman, N, Darst, S.A, Campbell, E.A. | Deposit date: | 2020-02-18 | Release date: | 2020-10-21 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.112 Å) | Cite: | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
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8QN8
| Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State II | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | Deposit date: | 2023-09-25 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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8R6P
| Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA, HelD N-terminal domain and open promoter DNA | Descriptor: | DNA 50-MER, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | Deposit date: | 2023-11-22 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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5VI5
| Structure of Mycobacterium smegmatis transcription initiation complex with a full transcription bubble | Descriptor: | 1,2-ETHANEDIOL, DNA (44-MER), DNA (49-MER), ... | Authors: | Darst, S.A, Campbell, E.A, Lilic, M. | Deposit date: | 2017-04-14 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.196 Å) | Cite: | Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures. Nat Commun, 8, 2017
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7P5X
| Mycobacterial RNAP with transcriptional activator PafBC | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. | Deposit date: | 2021-07-15 | Release date: | 2021-12-22 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
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6VVV
| Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase | Descriptor: | DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2020-02-18 | Release date: | 2020-10-21 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z11
| Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State III, primary channel dis-engaged and active site interfering | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Kouba, T, Koval, T, Krasny, L, Dohnalek, J. | Deposit date: | 2020-05-11 | Release date: | 2020-11-04 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | HelD, a helicase-like protein from gram-positive bacteria
in complex with RNA polymerase To Be Published
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8R2M
| Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD N-terminal domain and an upstream-fork promoter fragment; State III conformation | Descriptor: | DNA 22-MER, DNA 31-MER, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | Deposit date: | 2023-11-06 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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8QU6
| Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD and an upstream-fork promoter fragment | Descriptor: | DNA 22-MER, DNA 31-MER, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | Deposit date: | 2023-10-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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6DCF
| Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2018-05-06 | Release date: | 2018-09-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
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8R3M
| Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD N-terminal, CO and PCh loop domain, and an upstream-fork promoter fragment; State III conformation | Descriptor: | DNA 22-MER, DNA 31-MER, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | Deposit date: | 2023-11-09 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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6F6W
| Structure of Mycobacterium smegmatis RNA polymerase core | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Kouba, T, Barvik, I, Krasny, L. | Deposit date: | 2017-12-06 | Release date: | 2018-12-19 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.81 Å) | Cite: | The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis. J. Bacteriol., 201, 2019
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8R6R
| Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA and open promoter DNA | Descriptor: | DNA 50-MER, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | Deposit date: | 2023-11-22 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
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6EYD
| Structure of Mycobacterium smegmatis RNA polymerase Sigma-A holoenzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Kouba, T, Barvik, I, Krasny, L. | Deposit date: | 2017-11-11 | Release date: | 2018-12-12 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.22 Å) | Cite: | The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis. J. Bacteriol., 201, 2019
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