7JT3
 
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7JSZ
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6YST
 | | Structure of the P+9 ArfB-ribosome complex with P/E hybrid tRNA in the post-hydrolysis state | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Chan, K.-H, Petrychenko, V, Mueller, C, Maracci, C, Holtkamp, W, Wilson, D.N, Fischer, N, Rodnina, M.V. | | Deposit date: | 2020-04-23 | | Release date: | 2020-08-19 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Mechanism of ribosome rescue by alternative ribosome-rescue factor B.
Nat Commun, 11, 2020
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3TPE
 | | The phipa p3121 structure | | Descriptor: | Serine/threonine-protein kinase HipA | | Authors: | Schumacher, M.A, Link, T, Brennan, R.G. | | Deposit date: | 2011-09-07 | | Release date: | 2012-10-03 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance.
Cell Rep, 2, 2012
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6YSS
 | | Structure of the P+9 ArfB-ribosome complex in the post-hydrolysis state | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Chan, K.-H, Petrychenko, V, Mueller, C, Maracci, C, Holtkamp, W, Wilson, D.N, Fischer, N, Rodnina, M.V. | | Deposit date: | 2020-04-23 | | Release date: | 2020-08-19 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Mechanism of ribosome rescue by alternative ribosome-rescue factor B.
Nat Commun, 11, 2020
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1MJQ
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9BLN
 | | The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex | | Descriptor: | 40S ribosomal protein S14, ACETIC ACID, Eukaryotic initiation factor 4A-I, ... | | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Yifei, D, Albacete-Albacete, L, Ramakrishnan, V, S Fraser, C. | | Deposit date: | 2024-04-30 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit.
Nat Commun, 15, 2024
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9BKD
 | | The structure of human Pdcd4 bound to the 40S small ribosomal subunit | | Descriptor: | 18S rRNA, 40S ribosomal protein S12, 40S ribosomal protein S13, ... | | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Albacete-Albacete, L, Ramakrishnan, V, S.Fraser, C. | | Deposit date: | 2024-04-27 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit.
Nat Commun, 15, 2024
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7JT1
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3TPD
 | | Structure of pHipA, monoclinic form | | Descriptor: | CHLORIDE ION, PHOSPHATE ION, Serine/threonine-protein kinase HipA | | Authors: | schumacher, M.A, link, T, Brennan, R.G. | | Deposit date: | 2011-09-07 | | Release date: | 2012-10-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance.
Cell Rep, 2, 2012
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2FJ1
 | | Crystal Structure Analysis of Tet Repressor (class D) in Complex with 7-Chlortetracycline-Nickel(II) | | Descriptor: | 7-CHLOROTETRACYCLINE, CHLORIDE ION, NICKEL (II) ION, ... | | Authors: | Orth, P, Saenger, W, Palm, G.J, Hinrichs, W. | | Deposit date: | 2005-12-30 | | Release date: | 2007-01-09 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex.
J.Biol.Inorg.Chem., 13, 2008
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3TPT
 | | Structure of HipA(D309Q) bound to ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ... | | Authors: | schumacher, M.A, link, T, Brennan, R.G. | | Deposit date: | 2011-09-08 | | Release date: | 2012-10-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance.
Cell Rep, 2, 2012
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3TPB
 | | Structure of HipA(S150A) | | Descriptor: | CHLORIDE ION, PHOSPHATE ION, Serine/threonine-protein kinase HipA | | Authors: | schumacher, M.A. | | Deposit date: | 2011-09-07 | | Release date: | 2012-10-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance.
Cell Rep, 2, 2012
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4BHP
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4BH9
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2K40
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3TPV
 | | Structure of pHipA bound to ADP | | Descriptor: | ADENINE, SULFATE ION, Serine/threonine-protein kinase HipA | | Authors: | Schumacher, M.A, Link, T.M, Brennan, R.G. | | Deposit date: | 2011-09-08 | | Release date: | 2012-10-03 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance.
Cell Rep, 2, 2012
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9GRV
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 37 | | Descriptor: | 5-bromanylpyrimidine, DIMETHYL SULFOXIDE, Hepatoma-derived growth factor-related protein 2, ... | | Authors: | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | | Deposit date: | 2024-09-12 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7ZZU
 | | Inhibitory Ligand binding to HDAC2 | | Descriptor: | 1,2-ETHANEDIOL, 2-[4-[(2~{R},4~{S})-4-phenylpyrrolidin-2-yl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | | Authors: | Cleasby, A, Tisi, D. | | Deposit date: | 2022-05-26 | | Release date: | 2022-09-21 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Acs Med.Chem.Lett., 13, 2022
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9GRS
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 8 | | Descriptor: | 1-bromanyl-4-methylsulfonyl-benzene, DIMETHYL SULFOXIDE, Hepatoma-derived growth factor-related protein 2, ... | | Authors: | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | | Deposit date: | 2024-09-12 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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9GRT
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 29 | | Descriptor: | 4-bromo-1H-pyrazole, DIMETHYL SULFOXIDE, Hepatoma-derived growth factor-related protein 2, ... | | Authors: | Osipov, E.M, Paulovcakova, T, Beelen, S, Vantieghem, T, Strelkov, S.V. | | Deposit date: | 2024-09-12 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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9GCS
 | | Rho-ATP-Psu complex II | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Polarity suppression protein, ... | | Authors: | Gjorgjevikj, D, Wahl, M.C, Hilal, T, Loll, B. | | Deposit date: | 2024-08-02 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Rho-ATP-Psu complex II
To Be Published
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9GCU
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9G96
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 42 | | Descriptor: | 1,2-ETHANEDIOL, 4-[[(5-bromanylpyridin-3-yl)methylamino]methyl]aniline, Hepatoma-derived growth factor-related protein 2, ... | | Authors: | Vantieghem, T, Osipov, E.M, Strelkov, S.V. | | Deposit date: | 2024-07-24 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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9G91
 | | Crystal structure of HRP-2 PWWP domain in complex with compound 43 | | Descriptor: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | | Authors: | Vantieghem, T, Osipov, E.M, Strelkov, S.V. | | Deposit date: | 2024-07-24 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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